(31 nodes) Histone lysine methylation, and Nucleosome core network (Ectocarpus siliculosus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	rpl23	50S ribosomal protein L23, chloroplastic; Binds to 23S rRNA. (100 aa)
	Esi_0115_0076	GF22528. (1516 aa)
	Esi_0016_0129	Uncharacterized protein. (810 aa)
	Esi_0162_0064	Similar to SET domain, bifurcated 1. (1012 aa)
	Esi_0021_0081	Uncharacterized protein. (1677 aa)
	Esi_0213_0041	Uncharacterized protein. (108 aa)
	Esi_0306_0031	Histone H2A; Belongs to the histone H2A family. (134 aa)
	Esi_0057_0057	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
	Esi_0059_0077	Histone H3; Belongs to the histone H3 family. (136 aa)
	Esi_0037_0094	Histone H2B; Belongs to the histone H2B family. (116 aa)
	Esi_0306_0036	Histone H2A; Belongs to the histone H2A family. (122 aa)
	Esi_0034_0078	DOT1 domain-containing protein. (463 aa)
	Esi_0042_0126	Retinoblastoma binding protein 5. (597 aa)
	Esi_0435_0001	Uncharacterized protein. (552 aa)
	Esi_0442_0011	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (106 aa)
	Esi_0455_0010	SET domain-containing protein. (209 aa)
	Esi_0057_0052	Histone H2A; Belongs to the histone H2A family. (122 aa)
	Esi_0057_0055	Histone H3; Belongs to the histone H3 family. (120 aa)
	Esi_0057_0060	Similar to histone H3.2. (136 aa)
	Esi_0094_0082	Uncharacterized protein. (330 aa)
	Esi_0000_0259	Uncharacterized protein. (2317 aa)
	Esi_0000_0373	Uncharacterized protein. (207 aa)
	Esi_0100_0024	SET domain and mariner transposase fusion. (710 aa)
	CDK	Possible Cdc2-related protein kinase. (1898 aa)
	Esi_0038_0076	Uncharacterized protein. (237 aa)
	Esi_0004_0064	B30.2/SPRY domain-containing protein. (326 aa)
	Esi_0069_0089	Uncharacterized protein. (3474 aa)
	Esi_0007_0090	DOT1 domain-containing protein. (285 aa)
	Esi_0070_0045	Histone methyltransferase. (2067 aa)
	Esi_0076_0098	Uncharacterized protein. (292 aa)
	Esi_0095_0013	Fe2OG dioxygenase domain-containing protein. (441 aa)

Your Current Organism:

Ectocarpus siliculosus

NCBI taxonomy Id: 2880
Other names: E. siliculosus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDK	Esi_0000_0259	D8LK48	D8LB61	Possible Cdc2-related protein kinase.	Uncharacterized protein.	0.835
CDK	Esi_0000_0373	D8LK48	D8LBC4	Possible Cdc2-related protein kinase.	Uncharacterized protein.	0.588
CDK	Esi_0004_0064	D8LK48	D8LMA4	Possible Cdc2-related protein kinase.	B30.2/SPRY domain-containing protein.	0.799
CDK	Esi_0007_0090	D8LK48	D8LS24	Possible Cdc2-related protein kinase.	DOT1 domain-containing protein.	0.763
CDK	Esi_0016_0129	D8LK48	D7FLL4	Possible Cdc2-related protein kinase.	Uncharacterized protein.	0.596
CDK	Esi_0021_0081	D8LK48	D7FR56	Possible Cdc2-related protein kinase.	Uncharacterized protein.	0.447
CDK	Esi_0034_0078	D8LK48	D7FY79	Possible Cdc2-related protein kinase.	DOT1 domain-containing protein.	0.763
CDK	Esi_0037_0094	D8LK48	D7FWI8	Possible Cdc2-related protein kinase.	Histone H2B; Belongs to the histone H2B family.	0.908
CDK	Esi_0038_0076	D8LK48	D8LLY8	Possible Cdc2-related protein kinase.	Uncharacterized protein.	0.588
CDK	Esi_0042_0126	D8LK48	D7G0T3	Possible Cdc2-related protein kinase.	Retinoblastoma binding protein 5.	0.817
CDK	Esi_0057_0052	D8LK48	D7G4I2	Possible Cdc2-related protein kinase.	Histone H2A; Belongs to the histone H2A family.	0.683
CDK	Esi_0057_0055	D8LK48	D7G4I4	Possible Cdc2-related protein kinase.	Histone H3; Belongs to the histone H3 family.	0.801
CDK	Esi_0057_0057	D8LK48	D7FWI5	Possible Cdc2-related protein kinase.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.839
CDK	Esi_0057_0060	D8LK48	D7G4I9	Possible Cdc2-related protein kinase.	Similar to histone H3.2.	0.801
CDK	Esi_0059_0077	D8LK48	D7FWI7	Possible Cdc2-related protein kinase.	Histone H3; Belongs to the histone H3 family.	0.801
CDK	Esi_0069_0089	D8LK48	D8LRP6	Possible Cdc2-related protein kinase.	Uncharacterized protein.	0.748
CDK	Esi_0070_0045	D8LK48	D8LS62	Possible Cdc2-related protein kinase.	Histone methyltransferase.	0.748
CDK	Esi_0094_0082	D8LK48	D7G932	Possible Cdc2-related protein kinase.	Uncharacterized protein.	0.596
CDK	Esi_0095_0013	D8LK48	D8LU35	Possible Cdc2-related protein kinase.	Fe2OG dioxygenase domain-containing protein.	0.801
CDK	Esi_0100_0024	D8LK48	D8LC94	Possible Cdc2-related protein kinase.	SET domain and mariner transposase fusion.	0.596