(49 nodes) HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), and DNA recombinase assembly network (Ectocarpus siliculosus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Esi_0101_0091	Uncharacterized protein. (679 aa)
	Esi_0101_0092	DNA replication helicase Dna2, putative. (788 aa)
	RAD52	DNA repair protein RAD52 homolog. (566 aa)
	Esi_0114_0018	Similar to Werner syndrome protein. (727 aa)
	Esi_0124_0050	3'-5' exonuclease domain-containing protein. (955 aa)
	MRE11	Meiotic recombination 11. (939 aa)
	Esi_0189_0012	Rad51 domain-containing protein. (201 aa)
	Esi_0002_0181	annotation not available (562 aa)
	Esi_0203_0057	Uncharacterized protein. (448 aa)
	Esi_0021_0101	Exonuclease, putative 92014-93872. (587 aa)
	Esi_0231_0014	Putative, spindle assembly abnormal protein 6. (734 aa)
	Esi_0244_0009	Similar to ataxia telangiectasia and Rad3 related protein; Belongs to the PI3/PI4-kinase family. (2242 aa)
	Esi_0276_0016	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (759 aa)
	Esi_0279_0024	Replication protein A subunit. (419 aa)
	Esi_0279_0025	Rep-A_N domain-containing protein. (212 aa)
	Esi_0029_0066	annotation not available (249 aa)
	Esi_0003_0311	BRCT domain-containing protein. (1756 aa)
	Esi_0033_0067	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (807 aa)
	Esi_0034_0087	Uncharacterized protein; Belongs to the RecA family. (146 aa)
	Esi_0034_0089	Meiotic recombination protein DMC1/LIM15 homolog, putative. (251 aa)
	Esi_0369_0025	Exonuclease I Exo1. (620 aa)
	Esi_0379_0021	DEAD box helicase. (774 aa)
	Esi_0404_0005	3'-5' exonuclease domain-containing protein. (649 aa)
	Esi_0407_0030	Uncharacterized protein. (804 aa)
	Esi_0045_0024	Uncharacterized protein. (1925 aa)
	Esi_0465_0002	AAA_23 domain-containing protein. (442 aa)
	Esi_0049_0100	annotation not available (1629 aa)
	Esi_0521_0008	3'-5' exonuclease domain-containing protein. (818 aa)
	Rad51A	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily. (343 aa)
	Esi_0067_0019	Uncharacterized protein; Belongs to the RecA family. (329 aa)
	Rad51	Rad51 DNA recombinase 2. (335 aa)
	Esi_0008_0166	DNA topoisomerase I. (119 aa)
	Esi_0080_0023	Uncharacterized protein. (1552 aa)
	Esi_0092_0039	Rad51 homolog C. (344 aa)
	Esi_0098_0023	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (559 aa)
	Esi_0112_0011	Uncharacterized protein. (1165 aa)
	Esi_0126_0044	DNA topoisomerase I (Partial). (1050 aa)
	Esi_0158_0014	Helicase ATP-binding domain-containing protein. (572 aa)
	Esi_0158_0020	HELICc2 domain-containing protein. (415 aa)
	Esi_0167_0023	RECA_2 domain-containing protein. (330 aa)
	RecA	Recombinase A; Belongs to the RecA family. (453 aa)
	Esi_0202_0043	Tagatose-6-phosphate kinase-like protein. (385 aa)
	Esi_0292_0018	Nibrin. (668 aa)
	Esi_0031_0139	Endo/excinuclease amino terminal domain-containing protein. (350 aa)
	Esi_0322_0008	APEX nuclease (Apurinic/apyrimidinic endonuclease) 2. (321 aa)
	Esi_0044_0029	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (427 aa)
	Esi_0044_0036	Phosphatidylinositol kinase (PIK-5); Belongs to the PI3/PI4-kinase family. (3716 aa)
	Esi_0052_0197	Uncharacterized protein. (329 aa)
	Esi_0052_0199	BRCT domain-containing protein. (988 aa)

Your Current Organism:

Ectocarpus siliculosus

NCBI taxonomy Id: 2880
Other names: E. siliculosus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Esi_0002_0181	Esi_0003_0311	D7FQ61	D7FW83	annotation not available	BRCT domain-containing protein.	0.861
Esi_0002_0181	Esi_0008_0166	D7FQ61	D7G723	annotation not available	DNA topoisomerase I.	0.699
Esi_0002_0181	Esi_0021_0101	D7FQ61	D7FQX9	annotation not available	Exonuclease, putative 92014-93872.	0.620
Esi_0002_0181	Esi_0029_0066	D7FQ61	D7FVB3	annotation not available	annotation not available	0.992
Esi_0002_0181	Esi_0031_0139	D7FQ61	D8LKZ6	annotation not available	Endo/excinuclease amino terminal domain-containing protein.	0.728
Esi_0002_0181	Esi_0033_0067	D7FQ61	D7FXK3	annotation not available	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.598
Esi_0002_0181	Esi_0034_0087	D7FQ61	D7FY85	annotation not available	Uncharacterized protein; Belongs to the RecA family.	0.801
Esi_0002_0181	Esi_0034_0089	D7FQ61	D7FY86	annotation not available	Meiotic recombination protein DMC1/LIM15 homolog, putative.	0.801
Esi_0002_0181	Esi_0044_0029	D7FQ61	D8LNB3	annotation not available	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.883
Esi_0002_0181	Esi_0044_0036	D7FQ61	D8LNB7	annotation not available	Phosphatidylinositol kinase (PIK-5); Belongs to the PI3/PI4-kinase family.	0.883
Esi_0002_0181	Esi_0045_0024	D7FQ61	D7G1G0	annotation not available	Uncharacterized protein.	0.428
Esi_0002_0181	Esi_0049_0100	D7FQ61	D7G2Z1	annotation not available	annotation not available	0.891
Esi_0002_0181	Esi_0052_0197	D7FQ61	D8LPM7	annotation not available	Uncharacterized protein.	0.713
Esi_0002_0181	Esi_0052_0199	D7FQ61	D8LPM9	annotation not available	BRCT domain-containing protein.	0.428
Esi_0002_0181	Esi_0067_0019	D7FQ61	D7G5P5	annotation not available	Uncharacterized protein; Belongs to the RecA family.	0.809
Esi_0002_0181	Esi_0080_0023	D7FQ61	D7G795	annotation not available	Uncharacterized protein.	0.960
Esi_0002_0181	Esi_0092_0039	D7FQ61	D7G8V6	annotation not available	Rad51 homolog C.	0.801
Esi_0002_0181	Esi_0098_0023	D7FQ61	D7G9E9	annotation not available	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.992
Esi_0002_0181	Esi_0101_0091	D7FQ61	D7FGT6	annotation not available	Uncharacterized protein.	0.790
Esi_0002_0181	Esi_0101_0092	D7FQ61	D7FGT7	annotation not available	DNA replication helicase Dna2, putative.	0.790