(22 nodes) Cell redox homeostasis network (Ectocarpus siliculosus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Esi_0030_0003	Thioredoxin reductase. (400 aa)
	GCSL-2	Dihydrolipoamide dehydrogenase. (544 aa)
	Esi_0006_0185	Mercuric reductase. (573 aa)
	GSR-2	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (482 aa)
	PRX5	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (205 aa)
	Esi_0015_0018	Peroxiredoxin family protein. (218 aa)
	Esi_0014_0002	Soluble pyridine nucleotide transhydrogenase. (403 aa)
	GCSL	Dihydrolipoyl dehydrogenase. (502 aa)
	Esi_0098_0083	Mercuric reductase A. (399 aa)
	GSR	Glutathione reductase. (323 aa)
	SELT	Selenoprotein T. (307 aa)
	Esi_0008_0234	Uncharacterized protein. (210 aa)
	Esi_0051_0039	Electron donor (NADH / NADPH)-dependent reductase. (520 aa)
	Esi_0327_0031	Uncharacterized protein. (118 aa)
	Esi_0144_0069	Uncharacterized protein. (612 aa)
	Esi_0130_0046	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (225 aa)
	Esi_0119_0001	Glutathione reductase. (229 aa)
	Esi_0108_0050	Uncharacterized protein. (514 aa)
	TrxR	Thioredoxin reductase; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (773 aa)
	Esi_0007_0066	AhpC/TSA family protein. (192 aa)
	Esi_0254_0022	Thioredoxin domain-containing protein. (147 aa)
	Esi_0281_0018	Peroxiredoxin or Alkyl hydroperoxide reductase/ Thiol specific antioxidant. (233 aa)

Your Current Organism:

Ectocarpus siliculosus

NCBI taxonomy Id: 2880
Other names: E. siliculosus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Esi_0006_0185	Esi_0008_0234	D8LQL6	D7G770	Mercuric reductase.	Uncharacterized protein.	0.493
Esi_0006_0185	Esi_0030_0003	D8LQL6	D8LKE0	Mercuric reductase.	Thioredoxin reductase.	0.638
Esi_0006_0185	Esi_0130_0046	D8LQL6	D7FJA5	Mercuric reductase.	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily.	0.568
Esi_0006_0185	Esi_0327_0031	D8LQL6	D7FXG6	Mercuric reductase.	Uncharacterized protein.	0.493
Esi_0006_0185	PRX5	D8LQL6	D8LG20	Mercuric reductase.	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily.	0.568
Esi_0008_0234	Esi_0006_0185	D7G770	D8LQL6	Uncharacterized protein.	Mercuric reductase.	0.493
Esi_0008_0234	Esi_0014_0002	D7G770	D8LER9	Uncharacterized protein.	Soluble pyridine nucleotide transhydrogenase.	0.493
Esi_0008_0234	Esi_0051_0039	D7G770	D7G3G5	Uncharacterized protein.	Electron donor (NADH / NADPH)-dependent reductase.	0.493
Esi_0008_0234	Esi_0098_0083	D7G770	D7G9I3	Uncharacterized protein.	Mercuric reductase A.	0.493
Esi_0008_0234	Esi_0108_0050	D7G770	D7FHH4	Uncharacterized protein.	Uncharacterized protein.	0.493
Esi_0008_0234	Esi_0119_0001	D7G770	D7FI97	Uncharacterized protein.	Glutathione reductase.	0.493
Esi_0008_0234	Esi_0144_0069	D7G770	D7FKJ5	Uncharacterized protein.	Uncharacterized protein.	0.493
Esi_0008_0234	GCSL	D7G770	D8LBF4	Uncharacterized protein.	Dihydrolipoyl dehydrogenase.	0.493
Esi_0008_0234	GCSL-2	D7G770	D8LL48	Uncharacterized protein.	Dihydrolipoamide dehydrogenase.	0.493
Esi_0008_0234	GSR	D7G770	D7G8E2	Uncharacterized protein.	Glutathione reductase.	0.493
Esi_0008_0234	GSR-2	D7G770	D8LHC1	Uncharacterized protein.	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	0.493
Esi_0008_0234	TrxR	D7G770	D8LJA3	Uncharacterized protein.	Thioredoxin reductase; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	0.493
Esi_0014_0002	Esi_0008_0234	D8LER9	D7G770	Soluble pyridine nucleotide transhydrogenase.	Uncharacterized protein.	0.493
Esi_0014_0002	Esi_0030_0003	D8LER9	D8LKE0	Soluble pyridine nucleotide transhydrogenase.	Thioredoxin reductase.	0.723
Esi_0014_0002	Esi_0051_0039	D8LER9	D7G3G5	Soluble pyridine nucleotide transhydrogenase.	Electron donor (NADH / NADPH)-dependent reductase.	0.471