(19 nodes) Calnexin/calreticulin cycle network (Ectocarpus siliculosus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	UGGT-2	UDP-glucose:glycoprotein glucosyltransferase, C-terminal, family GT24. (1047 aa)
	Esi_0071_0107	UDP-glucose:glycoprotein glucosyltransferase, N-terminal, family GT24. (838 aa)
	GanAB	Alpha-glucosidase II alpha subunit, family GH31; Belongs to the glycosyl hydrolase 31 family. (521 aa)
	Esi_0097_0033	RING-CH-type domain-containing protein. (1644 aa)
	Esi_0000_0597	RING-CH-type domain-containing protein. (1305 aa)
	Esi_0013_0071	Similar to ubiquitin and ribosomal protein S27a. (100 aa)
	Esi_0130_0015	Calnexin. (593 aa)
	Esi_0062_0101	PA domain-containing protein. (218 aa)
	Esi_0070_0049	Ubiquitin. (129 aa)
	MAN1C1-3	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (496 aa)
	Esi_0009_0071	Ubiquitin-like domain-containing protein. (78 aa)
	EDEM1	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (699 aa)
	MAN1B1	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (822 aa)
	Esi_0150_0046	Uncharacterized protein. (377 aa)
	Esi_0193_0021	Vacuolar sorting receptor, putative (ISS). (104 aa)
	Esi_0208_0033	Uncharacterized protein. (672 aa)
	MAN1C1-2	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (944 aa)
	Esi_0363_0006	Calreticulin. (421 aa)
	UGGT	UDP-glucose:glycoprotein glucosyltransferase. (98 aa)

Your Current Organism:

Ectocarpus siliculosus

NCBI taxonomy Id: 2880
Other names: E. siliculosus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EDEM1	Esi_0062_0101	D8LTW3	D8LR62	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	PA domain-containing protein.	0.645
EDEM1	Esi_0130_0015	D8LTW3	D7FJ85	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	Calnexin.	0.578
EDEM1	Esi_0193_0021	D8LTW3	D7FPJ4	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	Vacuolar sorting receptor, putative (ISS).	0.645
Esi_0009_0071	Esi_0013_0071	D8LTN8	D8LE80	Ubiquitin-like domain-containing protein.	Similar to ubiquitin and ribosomal protein S27a.	0.526
Esi_0009_0071	Esi_0363_0006	D8LTN8	D7FZD0	Ubiquitin-like domain-containing protein.	Calreticulin.	0.404
Esi_0013_0071	Esi_0009_0071	D8LE80	D8LTN8	Similar to ubiquitin and ribosomal protein S27a.	Ubiquitin-like domain-containing protein.	0.526
Esi_0013_0071	Esi_0070_0049	D8LE80	D8LS65	Similar to ubiquitin and ribosomal protein S27a.	Ubiquitin.	0.447
Esi_0013_0071	Esi_0150_0046	D8LE80	D7FKZ7	Similar to ubiquitin and ribosomal protein S27a.	Uncharacterized protein.	0.510
Esi_0013_0071	Esi_0363_0006	D8LE80	D7FZD0	Similar to ubiquitin and ribosomal protein S27a.	Calreticulin.	0.404
Esi_0062_0101	EDEM1	D8LR62	D8LTW3	PA domain-containing protein.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.645
Esi_0062_0101	MAN1C1-2	D8LR62	D7FWV0	PA domain-containing protein.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.645
Esi_0062_0101	MAN1C1-3	D8LR62	D8LT19	PA domain-containing protein.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.645
Esi_0070_0049	Esi_0013_0071	D8LS65	D8LE80	Ubiquitin.	Similar to ubiquitin and ribosomal protein S27a.	0.447
Esi_0070_0049	Esi_0363_0006	D8LS65	D7FZD0	Ubiquitin.	Calreticulin.	0.404
Esi_0071_0107	Esi_0130_0015	D7G655	D7FJ85	UDP-glucose:glycoprotein glucosyltransferase, N-terminal, family GT24.	Calnexin.	0.605
Esi_0071_0107	Esi_0363_0006	D7G655	D7FZD0	UDP-glucose:glycoprotein glucosyltransferase, N-terminal, family GT24.	Calreticulin.	0.401
Esi_0071_0107	GanAB	D7G655	D7G789	UDP-glucose:glycoprotein glucosyltransferase, N-terminal, family GT24.	Alpha-glucosidase II alpha subunit, family GH31; Belongs to the glycosyl hydrolase 31 family.	0.610
Esi_0071_0107	UGGT-2	D7G655	D7G654	UDP-glucose:glycoprotein glucosyltransferase, N-terminal, family GT24.	UDP-glucose:glycoprotein glucosyltransferase, C-terminal, family GT24.	0.431
Esi_0130_0015	EDEM1	D7FJ85	D8LTW3	Calnexin.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.578
Esi_0130_0015	Esi_0071_0107	D7FJ85	D7G655	Calnexin.	UDP-glucose:glycoprotein glucosyltransferase, N-terminal, family GT24.	0.605