(51 nodes) Valine, leucine and isoleucine degradation network (Ectocarpus siliculosus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	ACAT1	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (425 aa)
	rbcL	Ribulose bisphosphate carboxylase large chain; RuBisCO catalyzes two reactions: the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site. (488 aa)
	Esi_0108_0050	Uncharacterized protein. (514 aa)
	Esi_0123_0030	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (380 aa)
	Esi_0144_0069	Uncharacterized protein. (612 aa)
	Esi_0147_0073	B12-binding domain-containing protein. (746 aa)
	Esi_0159_0007	Putative ribulose-1,5-bisphosphate carboxylase/oxygenase small subunit N-methyltransferase I. (521 aa)
	Esi_0016_0199	Enoyl-CoA hydratase. (260 aa)
	Esi_0018_0122	SET domain-containing protein. (444 aa)
	Esi_0002_0203	Uncharacterized protein. (370 aa)
	Esi_0223_0017	Acyl-CoA dehydrogenase. (411 aa)
	Esi_0003_0199	Set domain protein. (694 aa)
	Esi_0312_0022	Acyl-CoA dehydrogenase. (474 aa)
	Esi_0032_0021	Methylmalonate Semialdehyde Dehydrogenase. (526 aa)
	ACAA	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (383 aa)
	HMGS2	Hydroxymethylglutaryl-CoA synthase. (833 aa)
	Esi_0358_0027	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (623 aa)
	Esi_0358_0029	Branched chain alpha-keto acid dehydrogenase E1 beta subunit. (451 aa)
	Esi_0391_0008	Rubis-subs-bind domain-containing protein. (247 aa)
	Esi_0046_0134	Uncharacterized protein. (1030 aa)
	Esi_0475_0005	Predicted: Tubulin-tyrosine ligase-related protein. (720 aa)
	ACAT3	Acetyl-CoA acetyltransferase subunit, putative mitochondrial presursor Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (472 aa)
	Esi_0532_0009	Protein N-methyltransferase. (157 aa)
	Esi_0089_0111	SET domain-containing protein. (719 aa)
	Esi_0091_0014	Carboxylase. (570 aa)
	Esi_0098_0083	Mercuric reductase A. (399 aa)
	GCSL	Dihydrolipoyl dehydrogenase. (502 aa)
	Esi_0100_0033	Protein N-methyltransferase. (482 aa)
	Esi_0114_0058	Rubis-subs-bind domain-containing protein. (524 aa)
	HMGS1	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (502 aa)
	Esi_0151_0056	SET domain-containing protein. (451 aa)
	ACAT2	Acetyl-CoA acetyltransferase, putative mitochondrial presursor; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
	BCAT4	Branched chain amino acid aminotransferase. (614 aa)
	Esi_0031_0026	APH domain-containing protein. (805 aa)
	GCSL-2	Dihydrolipoamide dehydrogenase. (544 aa)
	Esi_0372_0027	Transportin 1 isoform 2. (873 aa)
	Esi_0038_0042	annotation not available (460 aa)
	Esi_0005_0083	Acyl-CoA dehydrogenase. (412 aa)
	Esi_0053_0040	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (250 aa)
	Esi_0059_0045	Pyruvate carboxyltransferase domain-containing protein. (335 aa)
	Esi_0006_0178	Carboxylase. (453 aa)
	Esi_0006_0185	Mercuric reductase. (573 aa)
	Esi_0006_0214	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (446 aa)
	Esi_0062_0124	SET domain-containing protein. (563 aa)
	MSDH	Methylmalonate Semialdehyde Dehydrogenase. (503 aa)
	Esi_0007_0146	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (407 aa)
	Esi_0007_0081	Hypothetical conserved protein. (149 aa)
	BCAT1	Branched chain amino acid aminotransferase. (352 aa)
	BCAT2	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (405 aa)
	BCAT3	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (430 aa)
	BCAT3-2	C-terminal branched chain amino acid aminotransferase BACT3. (116 aa)

Your Current Organism:

Ectocarpus siliculosus

NCBI taxonomy Id: 2880
Other names: E. siliculosus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAA	ACAT1	D7FX87	D7G8S8	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.786
ACAA	ACAT2	D7FX87	D8LH80	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase, putative mitochondrial presursor; Belongs to the thiolase-like superfamily. Thiolase family.	0.765
ACAA	ACAT3	D7FX87	D7G3H4	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase subunit, putative mitochondrial presursor Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.754
ACAA	Esi_0005_0083	D7FX87	D8LNP1	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl-CoA dehydrogenase.	0.881
ACAA	Esi_0006_0178	D7FX87	D8LQL0	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	Carboxylase.	0.809
ACAA	Esi_0007_0146	D7FX87	D8LRS7	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	0.868
ACAA	Esi_0016_0199	D7FX87	D7FLP7	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	Enoyl-CoA hydratase.	0.920
ACAA	Esi_0031_0026	D7FX87	D8LKT3	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	APH domain-containing protein.	0.794
ACAA	Esi_0032_0021	D7FX87	D7FX05	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	Methylmalonate Semialdehyde Dehydrogenase.	0.792
ACAA	Esi_0053_0040	D7FX87	D8LPQ4	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.755
ACAA	Esi_0059_0045	D7FX87	D8LQ51	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	Pyruvate carboxyltransferase domain-containing protein.	0.866
ACAA	Esi_0091_0014	D7FX87	D7G8N5	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	Carboxylase.	0.809
ACAA	Esi_0123_0030	D7FX87	D7FIS1	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	0.868
ACAA	Esi_0223_0017	D7FX87	D7FRX3	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl-CoA dehydrogenase.	0.794
ACAA	Esi_0312_0022	D7FX87	D7FWS9	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl-CoA dehydrogenase.	0.881
ACAA	Esi_0358_0027	D7FX87	D7FZ94	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.746
ACAA	HMGS1	D7FX87	D8LEJ9	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.967
ACAA	HMGS2	D7FX87	D7FXY3	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	Hydroxymethylglutaryl-CoA synthase.	0.970
ACAA	MSDH	D7FX87	D8LR91	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	Methylmalonate Semialdehyde Dehydrogenase.	0.792
ACAA	rbcL	D7FX87	D1J7D6	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	Ribulose bisphosphate carboxylase large chain; RuBisCO catalyzes two reactions: the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site.	0.809