(20 nodes) Tryptophan metabolism network (Ectocarpus siliculosus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Esi_0152_0060	Diphthami_syn_2 domain-containing protein. (739 aa)
	IDO	Indole 2,3-Dioxygenase. (498 aa)
	GCSL-2	Dihydrolipoamide dehydrogenase. (544 aa)
	Esi_0006_0185	Mercuric reductase. (573 aa)
	Esi_0066_0076	Putative Translation Initiation Inhibitor. (186 aa)
	Esi_0069_0075	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily. (354 aa)
	Esi_0099_0064	Uncharacterized protein. (814 aa)
	Esi_0358_0030	Amidase domain-containing protein. (614 aa)
	CAT-4	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (538 aa)
	Esi_0475_0005	Predicted: Tubulin-tyrosine ligase-related protein. (720 aa)
	Esi_0073_0036	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (409 aa)
	ACAT1	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (425 aa)
	Esi_0098_0083	Mercuric reductase A. (399 aa)
	Esi_0305_0003	Dihydrolipoamide succinyltransferase. (300 aa)
	Esi_0025_0089	Uncharacterized protein. (869 aa)
	Esi_0144_0069	Uncharacterized protein. (612 aa)
	GTPBP1	GTPBP1, EF1alpha-like GTPase. (539 aa)
	Esi_0108_0050	Uncharacterized protein. (514 aa)
	Esi_0141_0010	Putative Translation Initiation Inhibitor. (200 aa)
	GCSL	Dihydrolipoyl dehydrogenase. (502 aa)

Your Current Organism:

Ectocarpus siliculosus

NCBI taxonomy Id: 2880
Other names: E. siliculosus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAT1	Esi_0073_0036	D7G8S8	D7G687	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.702
ACAT1	Esi_0305_0003	D7G8S8	D7FWF4	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Dihydrolipoamide succinyltransferase.	0.702
CAT-4	Esi_0006_0185	D7G1K9	D8LQL6	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Mercuric reductase.	0.402
CAT-4	Esi_0098_0083	D7G1K9	D7G9I3	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Mercuric reductase A.	0.402
CAT-4	Esi_0108_0050	D7G1K9	D7FHH4	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Uncharacterized protein.	0.402
CAT-4	Esi_0144_0069	D7G1K9	D7FKJ5	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Uncharacterized protein.	0.402
CAT-4	GCSL	D7G1K9	D8LBF4	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Dihydrolipoyl dehydrogenase.	0.402
CAT-4	GCSL-2	D7G1K9	D8LL48	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Dihydrolipoamide dehydrogenase.	0.402
Esi_0006_0185	CAT-4	D8LQL6	D7G1K9	Mercuric reductase.	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	0.402
Esi_0006_0185	Esi_0073_0036	D8LQL6	D7G687	Mercuric reductase.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.911
Esi_0006_0185	Esi_0305_0003	D8LQL6	D7FWF4	Mercuric reductase.	Dihydrolipoamide succinyltransferase.	0.911
Esi_0073_0036	ACAT1	D7G687	D7G8S8	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.702
Esi_0073_0036	Esi_0006_0185	D7G687	D8LQL6	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Mercuric reductase.	0.911
Esi_0073_0036	Esi_0098_0083	D7G687	D7G9I3	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Mercuric reductase A.	0.911
Esi_0073_0036	Esi_0108_0050	D7G687	D7FHH4	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Uncharacterized protein.	0.911
Esi_0073_0036	Esi_0144_0069	D7G687	D7FKJ5	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Uncharacterized protein.	0.911
Esi_0073_0036	Esi_0305_0003	D7G687	D7FWF4	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Dihydrolipoamide succinyltransferase.	0.499
Esi_0073_0036	GCSL	D7G687	D8LBF4	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Dihydrolipoyl dehydrogenase.	0.954
Esi_0073_0036	GCSL-2	D7G687	D8LL48	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Dihydrolipoamide dehydrogenase.	0.954
Esi_0098_0083	CAT-4	D7G9I3	D7G1K9	Mercuric reductase A.	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	0.402