(90 nodes) Pyruvate metabolism network (Ectocarpus siliculosus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Esi_0088_0011	UBA/TS-N domain containing protein. (825 aa)
	Esi_0088_0007	Uncharacterized protein. (737 aa)
	Esi_0687_0003	Uncharacterized protein. (419 aa)
	Esi_0640_0006	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (391 aa)
	ACC-4	Acetyl-CoA carboxylase, partial. (798 aa)
	Esi_0055_0027	Bms1-type G domain-containing protein. (840 aa)
	BBS1	Bardet-Biedl syndrome 1. (602 aa)
	Esi_0475_0005	Predicted: Tubulin-tyrosine ligase-related protein. (720 aa)
	ACC-3	Acetyl-CoA carboxylase, partial. (165 aa)
	ACC-2	Acetyl-CoA carboxylase, partial. (231 aa)
	Esi_0393_0004	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (601 aa)
	Esi_0332_0013	Uncharacterized protein. (1062 aa)
	Esi_0339_0018	ATP-grasp domain-containing protein. (525 aa)
	Esi_0344_0024	Uncharacterized protein; Belongs to the LDH/MDH superfamily. (399 aa)
	ACC	Acetyl-CoA carboxylase, partial. (1048 aa)
	Esi_0349_0012	Pyruvate kinase; Belongs to the pyruvate kinase family. (504 aa)
	Esi_0101_0069	Lactamase_B domain-containing protein. (255 aa)
	Esi_0102_0069	Lipoyl-binding domain-containing protein. (370 aa)
	Esi_0108_0050	Uncharacterized protein. (514 aa)
	Pyruvate	Pyruvate dehydrogenase E1 component alpha subunit, mitochondrial (PDHE1-A). (354 aa)
	Esi_0123_0054	Lactamase_B domain-containing protein. (298 aa)
	Esi_0135_0008	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (641 aa)
	Esi_0136_0001	Hydroxyacylglutathione hydrolase, putative. (161 aa)
	Esi_0136_0009	Lactamase_B domain-containing protein. (361 aa)
	Esi_0143_0002	Mitochondrial carrier family; Belongs to the mitochondrial carrier (TC 2.A.29) family. (253 aa)
	Esi_0144_0069	Uncharacterized protein. (612 aa)
	Esi_0016_0165	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (778 aa)
	Esi_0161_0001	Uncharacterized protein. (290 aa)
	Esi_0162_0026	Uncharacterized protein. (362 aa)
	Esi_0163_0048	Dihydrolipoamide S-acetyltransferase. (1262 aa)
	Esi_0173_0060	Fumarate hydratase. (608 aa)
	Esi_0184_0024	Mitochondrial phosphate carrier protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (674 aa)
	Esi_0187_0034	DRTGG domain-containing protein. (181 aa)
	Esi_0187_0035	Uncharacterized protein. (181 aa)
	Esi_0193_0046	Ankyrin repeat protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1207 aa)
	PYK	Pyruvate kinase; Belongs to the pyruvate kinase family. (499 aa)
	Esi_0002_0336	Lactamase_B domain-containing protein. (343 aa)
	Esi_0002_0342	Zn dependent hydrolase or glyoxylase. (343 aa)
	Esi_0209_0029	Cytosolic malate dehydrogenase. (99 aa)
	MDH	Malate dehydrogenase. (276 aa)
	Esi_0215_0009	Uncharacterized protein. (374 aa)
	PDH	Pyruvate dehydrogenase E1 component subunit beta. (125 aa)
	Esi_0025_0029	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1340 aa)
	Esi_0265_0041	annotation not available (383 aa)
	Esi_0278_0034	PARP catalytic domain-containing protein. (939 aa)
	Esi_0278_0043	PARP catalytic domain-containing protein. (571 aa)
	Esi_0280_0003	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (928 aa)
	Esi_0298_0022	WW domain-containing protein. (147 aa)
	Esi_0298_0023	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1148 aa)
	Esi_0003_0295	Malic enzyme. (548 aa)
	Esi_0300_0012	Amino acid transporter. (563 aa)
	Esi_0319_0028	Malic_M domain-containing protein. (103 aa)
	Esi_0326_0032	Dihydrolipoamide acetyltransferase. (321 aa)
	Esi_0099_0038	Uncharacterized protein. (410 aa)
	Esi_0090_0061	Malate synthase; Belongs to the malate synthase family. (534 aa)
	IPMS3	2-Isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (606 aa)
	Esi_0009_0090	Lipoyl-binding domain-containing protein. (221 aa)
	PPC	Phosphoenolpyruvate carboxylase. (949 aa)
	Esi_0062_0031	Uncharacterized protein. (141 aa)
	Esi_0061_0055	NAD dependent malate dehydrogenase. (372 aa)
	Esi_0061_0053	Malic_M domain-containing protein. (218 aa)
	Esi_0061_0051	Malate dehydrogenase. (453 aa)
	MDH4	Malate dehydrogenase. (349 aa)
	Esi_0006_0185	Mercuric reductase. (573 aa)
	PYK-2	Pyruvate kinase; Belongs to the pyruvate kinase family. (623 aa)
	Esi_0038_0129	Carboxylase. (1235 aa)
	Esi_0037_0124	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (983 aa)
	Esi_0036_0136	Kinesin (KAR3 subfamily) (Partial); Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1167 aa)
	Esi_0322_0032	Dihydrolipoamide acetyltransferase. (295 aa)
	Esi_0322_0031	Dihydrolipoamide acetyltransferase (Partial). (219 aa)
	GCSL-2	Dihydrolipoamide dehydrogenase. (544 aa)
	Esi_0220_0031	Uncharacterized protein. (708 aa)
	PDH-3	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (362 aa)
	PPDK	Pyruvate, phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (946 aa)
	Esi_0020_0105	VOC domain-containing protein. (185 aa)
	IPMS2	2-Isopropylmalate synthase. (515 aa)
	ACC-6	Acetyl-CoA carboxylase. (1847 aa)
	Esi_0197_0042	D-lactate dehydrognease 2, putative. (202 aa)
	Esi_0152_0013	DRTGG domain-containing protein. (408 aa)
	Esi_0148_0046	Uncharacterized protein. (396 aa)
	PDH-2	Pyruvate dehydrogenase. (806 aa)
	Esi_0013_0133	Putative decarboxylase family protein, lysine decarboxylase. (245 aa)
	FUMH	Fumarate hydratase (Fumarase). (482 aa)
	Esi_0126_0079	Uncharacterized protein. (3616 aa)
	PYC	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1152 aa)
	GCSL	Dihydrolipoyl dehydrogenase. (502 aa)
	Esi_0000_0252	Glyoxalase domain containing protein. (428 aa)
	Esi_0098_0083	Mercuric reductase A. (399 aa)
	ACAT1	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (425 aa)
	MPC	N/a; Belongs to the mitochondrial carrier (TC 2.A.29) family. (833 aa)

Your Current Organism:

Ectocarpus siliculosus

NCBI taxonomy Id: 2880
Other names: E. siliculosus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAT1	ACC	D7G8S8	D7FZG6	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA carboxylase, partial.	0.668
ACAT1	ACC-2	D7G8S8	D7G0I9	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA carboxylase, partial.	0.668
ACAT1	ACC-3	D7G8S8	D7G0J0	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA carboxylase, partial.	0.668
ACAT1	ACC-4	D7G8S8	D7G4Z4	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA carboxylase, partial.	0.668
ACAT1	ACC-6	D7G8S8	D8LHP3	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA carboxylase.	0.668
ACAT1	Esi_0003_0295	D7G8S8	D7FW76	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Malic enzyme.	0.571
ACAT1	Esi_0009_0090	D7G8S8	D8LTQ3	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Lipoyl-binding domain-containing protein.	0.616
ACAT1	Esi_0038_0129	D7G8S8	D8LM14	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Carboxylase.	0.603
ACAT1	Esi_0061_0051	D7G8S8	D8LQY1	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Malate dehydrogenase.	0.571
ACAT1	Esi_0061_0053	D7G8S8	D8LQY2	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Malic_M domain-containing protein.	0.571
ACAT1	Esi_0061_0055	D7G8S8	D8LQY3	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	NAD dependent malate dehydrogenase.	0.571
ACAT1	Esi_0090_0061	D7G8S8	D8LTY7	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Malate synthase; Belongs to the malate synthase family.	0.846
ACAT1	Esi_0102_0069	D7G8S8	D7FGX3	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Lipoyl-binding domain-containing protein.	0.616
ACAT1	Esi_0152_0013	D7G8S8	D8LFV3	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	DRTGG domain-containing protein.	0.594
ACAT1	Esi_0163_0048	D7G8S8	D7FM36	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Dihydrolipoamide S-acetyltransferase.	0.616
ACAT1	Esi_0187_0034	D7G8S8	D7FP84	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	DRTGG domain-containing protein.	0.594
ACAT1	Esi_0187_0035	D7G8S8	D7FP85	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein.	0.594
ACAT1	Esi_0197_0042	D7G8S8	D8LHN2	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	D-lactate dehydrognease 2, putative.	0.457
ACAT1	Esi_0319_0028	D7G8S8	D7FWZ7	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Malic_M domain-containing protein.	0.571
ACAT1	Esi_0322_0031	D7G8S8	D8LL61	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Dihydrolipoamide acetyltransferase (Partial).	0.616