(47 nodes) Glyoxylate and dicarboxylate metabolism network (Ectocarpus siliculosus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Esi_0003_0046	Carboxyvinyl-carboxyphosphonate phosphorylmutase. (351 aa)
	Esi_0025_0089	Uncharacterized protein. (869 aa)
	Esi_0221_0023	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1000 aa)
	MDH	Malate dehydrogenase. (276 aa)
	Esi_0209_0029	Cytosolic malate dehydrogenase. (99 aa)
	Esi_0188_0005	Glutamine synthetase. (334 aa)
	Esi_0188_0004	Glutamine synthetase. (363 aa)
	Esi_0018_0122	SET domain-containing protein. (444 aa)
	Esi_0179_0062	Novel protein. (1353 aa)
	Esi_0016_0022	AAA domain-containing protein. (709 aa)
	Esi_0159_0007	Putative ribulose-1,5-bisphosphate carboxylase/oxygenase small subunit N-methyltransferase I. (521 aa)
	Esi_0159_0005	Isocitrate lyase. (589 aa)
	Esi_0147_0073	B12-binding domain-containing protein. (746 aa)
	Esi_0144_0069	Uncharacterized protein. (612 aa)
	Esi_0108_0050	Uncharacterized protein. (514 aa)
	SHMT2-3	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (491 aa)
	Esi_0090_0061	Malate synthase; Belongs to the malate synthase family. (534 aa)
	Esi_0072_0092	Glutamine synthetase. (407 aa)
	Esi_0062_0124	SET domain-containing protein. (563 aa)
	MDH4	Malate dehydrogenase. (349 aa)
	Esi_0006_0185	Mercuric reductase. (573 aa)
	Esi_0038_0042	annotation not available (460 aa)
	Esi_0036_0001	Similar to Calcium-independent phospholipase A2-gamma, C terminal part. (370 aa)
	SHMT2-2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (538 aa)
	GCSL-2	Dihydrolipoamide dehydrogenase. (544 aa)
	Esi_0292_0040	Uncharacterized protein. (194 aa)
	Esi_0019_0094	Folate-binding protein YgfZ. (544 aa)
	Esi_0168_0057	D-isomer specific 2-hydroxyacid dehydrogenase. (339 aa)
	Esi_0157_0054	Uncharacterized protein. (454 aa)
	Esi_0151_0056	SET domain-containing protein. (451 aa)
	SHMT2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (471 aa)
	Esi_0114_0058	Rubis-subs-bind domain-containing protein. (524 aa)
	Esi_0112_0047	AAA domain-containing protein; Belongs to the AAA ATPase family. (498 aa)
	Esi_0100_0033	Protein N-methyltransferase. (482 aa)
	GCSL	Dihydrolipoyl dehydrogenase. (502 aa)
	Esi_0098_0083	Mercuric reductase A. (399 aa)
	ACAT1	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (425 aa)
	Esi_0089_0111	SET domain-containing protein. (719 aa)
	Esi_0532_0009	Protein N-methyltransferase. (157 aa)
	Esi_0046_0134	Uncharacterized protein. (1030 aa)
	Esi_0046_0033	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (419 aa)
	GCSH	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (170 aa)
	CAT-4	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (538 aa)
	Esi_0391_0008	Rubis-subs-bind domain-containing protein. (247 aa)
	Esi_0344_0024	Uncharacterized protein; Belongs to the LDH/MDH superfamily. (399 aa)
	Esi_0003_0199	Set domain protein. (694 aa)
	Esi_0294_0029	Asparagine synthetase domain-containing protein. (347 aa)

Your Current Organism:

Ectocarpus siliculosus

NCBI taxonomy Id: 2880
Other names: E. siliculosus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAT1	Esi_0003_0046	D7G8S8	D7FVV1	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Carboxyvinyl-carboxyphosphonate phosphorylmutase.	0.748
ACAT1	Esi_0090_0061	D7G8S8	D8LTY7	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Malate synthase; Belongs to the malate synthase family.	0.846
ACAT1	Esi_0159_0005	D7G8S8	D7FLB9	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Isocitrate lyase.	0.748
ACAT1	Esi_0292_0040	D7G8S8	D8LKC6	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein.	0.896
ACAT1	GCSH	D7G8S8	D7G1U2	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	0.525
CAT-4	Esi_0006_0185	D7G1K9	D8LQL6	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Mercuric reductase.	0.402
CAT-4	Esi_0090_0061	D7G1K9	D8LTY7	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Malate synthase; Belongs to the malate synthase family.	0.411
CAT-4	Esi_0098_0083	D7G1K9	D7G9I3	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Mercuric reductase A.	0.402
CAT-4	Esi_0108_0050	D7G1K9	D7FHH4	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Uncharacterized protein.	0.402
CAT-4	Esi_0144_0069	D7G1K9	D7FKJ5	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Uncharacterized protein.	0.402
CAT-4	GCSL	D7G1K9	D8LBF4	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Dihydrolipoyl dehydrogenase.	0.402
CAT-4	GCSL-2	D7G1K9	D8LL48	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Dihydrolipoamide dehydrogenase.	0.402
Esi_0003_0046	ACAT1	D7FVV1	D7G8S8	Carboxyvinyl-carboxyphosphonate phosphorylmutase.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.748
Esi_0003_0046	Esi_0090_0061	D7FVV1	D8LTY7	Carboxyvinyl-carboxyphosphonate phosphorylmutase.	Malate synthase; Belongs to the malate synthase family.	0.874
Esi_0003_0046	Esi_0168_0057	D7FVV1	D8LGJ7	Carboxyvinyl-carboxyphosphonate phosphorylmutase.	D-isomer specific 2-hydroxyacid dehydrogenase.	0.765
Esi_0003_0046	Esi_0209_0029	D7FVV1	D7FQW0	Carboxyvinyl-carboxyphosphonate phosphorylmutase.	Cytosolic malate dehydrogenase.	0.732
Esi_0003_0046	Esi_0292_0040	D7FVV1	D8LKC6	Carboxyvinyl-carboxyphosphonate phosphorylmutase.	Uncharacterized protein.	0.964
Esi_0003_0046	Esi_0344_0024	D7FVV1	D7FYH6	Carboxyvinyl-carboxyphosphonate phosphorylmutase.	Uncharacterized protein; Belongs to the LDH/MDH superfamily.	0.732
Esi_0003_0046	MDH	D7FVV1	D7FQW1	Carboxyvinyl-carboxyphosphonate phosphorylmutase.	Malate dehydrogenase.	0.732
Esi_0003_0046	MDH4	D7FVV1	D8LQM3	Carboxyvinyl-carboxyphosphonate phosphorylmutase.	Malate dehydrogenase.	0.820