(30 nodes) One carbon pool by folate network (Ectocarpus siliculosus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

gene neighborhood

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Your Input:
	SHMT2-2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (538 aa)
	Esi_0179_0062	Novel protein. (1353 aa)
	Esi_0018_0024	Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...] (498 aa)
	Esi_0203_0046	5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (256 aa)
	Esi_0305_0037	Putative methylene tetrahydrofolate dehydrogenase. (343 aa)
	Esi_0036_0001	Similar to Calcium-independent phospholipase A2-gamma, C terminal part. (370 aa)
	Esi_0044_0118	Uncharacterized protein. (749 aa)
	Esi_0046_0033	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (419 aa)
	Esi_0091_0089	Methyltrans_SAM domain-containing protein. (244 aa)
	SHMT2-3	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (491 aa)
	Esi_0099_0014	Uncharacterized protein. (517 aa)
	Esi_0009_0081	Uncharacterized protein. (292 aa)
	Esi_0081_0020	ATP-grasp domain-containing protein. (1217 aa)
	Esi_0078_0011	Uncharacterized protein. (299 aa)
	Esi_0078_0010	Uncharacterized protein. (330 aa)
	Esi_0011_0107	Uncharacterized protein. (399 aa)
	Esi_0116_0039	Uncharacterized protein. (642 aa)
	SHMT2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (471 aa)
	IDS	4-hydroxy-3-methylbut-2-enyl diphosphate reductase, chloroplast. (454 aa)
	Esi_0181_0049	Methyltrans_SAM domain-containing protein. (257 aa)
	Esi_0019_0004	ACT domain-containing protein. (339 aa)
	Esi_0019_0094	Folate-binding protein YgfZ. (544 aa)
	Esi_0022_0060	Rhodanese Homology Domain superfamily. (874 aa)
	Esi_0292_0008	Uncharacterized protein. (57 aa)
	Esi_0056_0101	Uncharacterized protein. (491 aa)
	Esi_0066_0065	HNH endonuclease family protein. (332 aa)
	Esi_0030_0091	Rhodanese domain-containing protein. (451 aa)
	Esi_0031_0020	Probable bifunctional purine synthesis protein. (610 aa)
	FMT	Methionyl-tRNA formyltransferase. (451 aa)
	Esi_0000_0340	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. (581 aa)

Your Current Organism:

Ectocarpus siliculosus

NCBI taxonomy Id: 2880
Other names: E. siliculosus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Esi_0000_0340	Esi_0009_0081	D8LBA4	D8LTP6	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	Uncharacterized protein.	0.925
Esi_0000_0340	Esi_0011_0107	D8LBA4	D8LCN9	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	Uncharacterized protein.	0.905
Esi_0000_0340	Esi_0018_0024	D8LBA4	D7FNG2	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...]	0.825
Esi_0000_0340	Esi_0019_0004	D8LBA4	D8LH40	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	ACT domain-containing protein.	0.928
Esi_0000_0340	Esi_0019_0094	D8LBA4	D8LH90	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	Folate-binding protein YgfZ.	0.924
Esi_0000_0340	Esi_0022_0060	D8LBA4	D8LIE1	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	Rhodanese Homology Domain superfamily.	0.850
Esi_0000_0340	Esi_0030_0091	D8LBA4	D8LKI5	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	Rhodanese domain-containing protein.	0.850
Esi_0000_0340	Esi_0031_0020	D8LBA4	D8LKS8	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	Probable bifunctional purine synthesis protein.	0.952
Esi_0000_0340	Esi_0044_0118	D8LBA4	D8LNF9	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	Uncharacterized protein.	0.850
Esi_0000_0340	Esi_0046_0033	D8LBA4	D7G1U3	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	0.924
Esi_0000_0340	Esi_0056_0101	D8LBA4	D8LQ10	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	Uncharacterized protein.	0.925
Esi_0000_0340	Esi_0066_0065	D8LBA4	D8LRG1	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	HNH endonuclease family protein.	0.474
Esi_0000_0340	Esi_0078_0010	D8LBA4	D8LT25	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	Uncharacterized protein.	0.905
Esi_0000_0340	Esi_0078_0011	D8LBA4	D8LT26	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	Uncharacterized protein.	0.905
Esi_0000_0340	Esi_0081_0020	D8LBA4	D8LT70	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	ATP-grasp domain-containing protein.	0.983
Esi_0000_0340	Esi_0099_0014	D8LBA4	D8LU87	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	Uncharacterized protein.	0.925
Esi_0000_0340	Esi_0116_0039	D8LBA4	D8LDA9	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	Uncharacterized protein.	0.942
Esi_0000_0340	Esi_0203_0046	D8LBA4	D7FQL2	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.	0.573
Esi_0000_0340	Esi_0292_0008	D8LBA4	D8LKA5	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	Uncharacterized protein.	0.942
Esi_0000_0340	Esi_0305_0037	D8LBA4	D7FWG9	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	Putative methylene tetrahydrofolate dehydrogenase.	0.925