(32 nodes) 2-Oxocarboxylic acid metabolism network (Ectocarpus siliculosus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	Esi_0002_0203	Uncharacterized protein. (370 aa)
	Esi_0002_0158	Aspartate-semialdehyde dehydrogenase. (348 aa)
	Esi_0164_0038	M20_dimer domain-containing protein. (374 aa)
	ARGA	Amino-acid N-acetyltransferase. (497 aa)
	ilvH	Acetolactate synthase small subunit. (194 aa)
	ilvB	Acetolactate synthase. (735 aa)
	BCAT3	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (430 aa)
	BCAT3-2	C-terminal branched chain amino acid aminotransferase BACT3. (116 aa)
	IPMS3	2-Isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (606 aa)
	BCAT2	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (405 aa)
	BCAT1	Branched chain amino acid aminotransferase. (352 aa)
	NAG-PR	N-acetyl-gamma-glutamyl-phosphate reductase, C-terminal part. (355 aa)
	Esi_0069_0026	3-isopropylmalate dehydratase. (255 aa)
	Esi_0038_0153	M20_dimer domain-containing protein. (446 aa)
	Esi_0292_0040	Uncharacterized protein. (194 aa)
	BCAT4	Branched chain amino acid aminotransferase. (614 aa)
	IPMS2	2-Isopropylmalate synthase. (515 aa)
	ARGB	Acetylglutamate kinase. (359 aa)
	OsNAAT1-2	Nicotinanamine aminotransferase A. (490 aa)
	Esi_0068_0069	Putative homoaconitate hydratase, N-terminal part. (278 aa)
	Esi_0068_0067	Putative homoaconitate hydratase, c-terminal part. (283 aa)
	Esi_0048_0101	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
	Esi_0476_0015	Arginine biosynthesis bifunctional protein ArgJ, mitochondrial; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate; Belongs to the ArgJ family. (473 aa)
	IMDH	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (427 aa)
	AK1	Aspartokinase; Belongs to the aspartokinase family. (469 aa)
	AAT	Aspartate aminotransferase. (401 aa)
	Esi_0298_0027	Alanine transaminase. (510 aa)
	DAD-3	Dihydroxy-acid dehydratase, N-termnial part. (312 aa)
	DAD-2	Dihydroxy-acid dehydratase. (64 aa)
	DAD	Dihydroxy-acid dehydratase, C-termnial part. (213 aa)
	Esi_0215_0007	M20_dimer domain-containing protein. (489 aa)
	ACO	Aconitate hydratase. (788 aa)

Your Current Organism:

Ectocarpus siliculosus

NCBI taxonomy Id: 2880
Other names: E. siliculosus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AAT	ACO	D7FVR8	D7FQN5	Aspartate aminotransferase.	Aconitate hydratase.	0.671
AAT	AK1	D7FVR8	D7FXQ9	Aspartate aminotransferase.	Aspartokinase; Belongs to the aspartokinase family.	0.827
AAT	ARGA	D7FVR8	D7FJG3	Aspartate aminotransferase.	Amino-acid N-acetyltransferase.	0.727
AAT	ARGB	D7FVR8	D8LH55	Aspartate aminotransferase.	Acetylglutamate kinase.	0.727
AAT	BCAT1	D7FVR8	D8LT73	Aspartate aminotransferase.	Branched chain amino acid aminotransferase.	0.641
AAT	BCAT2	D7FVR8	D8LT74	Aspartate aminotransferase.	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.641
AAT	BCAT3	D7FVR8	D8LT77	Aspartate aminotransferase.	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.641
AAT	BCAT3-2	D7FVR8	D8LT78	Aspartate aminotransferase.	C-terminal branched chain amino acid aminotransferase BACT3.	0.641
AAT	BCAT4	D7FVR8	D8LIS9	Aspartate aminotransferase.	Branched chain amino acid aminotransferase.	0.641
AAT	Esi_0002_0158	D7FVR8	D7FQ51	Aspartate aminotransferase.	Aspartate-semialdehyde dehydrogenase.	0.410
AAT	Esi_0002_0203	D7FVR8	D7FQ75	Aspartate aminotransferase.	Uncharacterized protein.	0.641
AAT	Esi_0038_0153	D7FVR8	D8LM29	Aspartate aminotransferase.	M20_dimer domain-containing protein.	0.656
AAT	Esi_0048_0101	D7FVR8	D7G2Q2	Aspartate aminotransferase.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.893
AAT	Esi_0164_0038	D7FVR8	D7FM78	Aspartate aminotransferase.	M20_dimer domain-containing protein.	0.656
AAT	Esi_0215_0007	D7FVR8	D7FRI0	Aspartate aminotransferase.	M20_dimer domain-containing protein.	0.656
AAT	Esi_0292_0040	D7FVR8	D8LKC6	Aspartate aminotransferase.	Uncharacterized protein.	0.897
AAT	Esi_0298_0027	D7FVR8	D7FVQ6	Aspartate aminotransferase.	Alanine transaminase.	0.836
AAT	Esi_0476_0015	D7FVR8	D7G2H9	Aspartate aminotransferase.	Arginine biosynthesis bifunctional protein ArgJ, mitochondrial; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate; Belongs to the ArgJ family.	0.720
AAT	IMDH	D7FVR8	D7G282	Aspartate aminotransferase.	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	0.825
AAT	OsNAAT1-2	D7FVR8	D7G750	Aspartate aminotransferase.	Nicotinanamine aminotransferase A.	0.836