(78 nodes) Homologous recombination network (Ectocarpus siliculosus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Rad51	Rad51 DNA recombinase 2. (335 aa)
	Esi_0006_0201	ERCC4 domain containing protein. (598 aa)
	Esi_0052_0199	BRCT domain-containing protein. (988 aa)
	Esi_0052_0197	Uncharacterized protein. (329 aa)
	Esi_0052_0133	EsV-1-126. (206 aa)
	DNA-2	DNA polymerase. (1047 aa)
	Esi_0044_0036	Phosphatidylinositol kinase (PIK-5); Belongs to the PI3/PI4-kinase family. (3716 aa)
	Esi_0044_0029	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (427 aa)
	Esi_0041_0029	SNF2-related domain-containing protein. (1075 aa)
	Esi_0041_0002	Pol1-like DNA polymerase. (1473 aa)
	Esi_0004_0157	Uncharacterized protein. (288 aa)
	Esi_0322_0008	APEX nuclease (Apurinic/apyrimidinic endonuclease) 2. (321 aa)
	Esi_0292_0018	Nibrin. (668 aa)
	Esi_0264_0023	Uncharacterized protein. (80 aa)
	Esi_0202_0043	Tagatose-6-phosphate kinase-like protein. (385 aa)
	Esi_0019_0012	Uncharacterized protein. (423 aa)
	RecA	Recombinase A; Belongs to the RecA family. (453 aa)
	Esi_0167_0023	RECA_2 domain-containing protein. (330 aa)
	Esi_0158_0020	HELICc2 domain-containing protein. (415 aa)
	Esi_0137_0036	ATP-dependent DNA helicase; Belongs to the helicase family. (196 aa)
	Esi_0095_0027	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (645 aa)
	dnaB	Replicative DNA helicase. (584 aa)
	RAD52	DNA repair protein RAD52 homolog. (566 aa)
	Esi_0140_0042	DNA polymerase. (1219 aa)
	Esi_0159_0024	Helicase ATP-binding domain-containing protein. (1061 aa)
	Esi_0163_0009	DNA polymerase I (POL I). (482 aa)
	Esi_0163_0012	DEAD box helicase. (1907 aa)
	Esi_0164_0027	Procaryotic DNA polymerase I. (485 aa)
	MRE11	Meiotic recombination 11. (939 aa)
	Esi_0189_0012	Rad51 domain-containing protein. (201 aa)
	Esi_0194_0042	ATP-dependent DNA helicase RecG. (1002 aa)
	Esi_0002_0181	annotation not available (562 aa)
	Esi_0203_0057	Uncharacterized protein. (448 aa)
	Esi_0021_0019	DEAD box helicase. (1537 aa)
	Esi_0021_0079	DEAD box helicase; Belongs to the DEAD box helicase family. (516 aa)
	Esi_0225_0015	ATP-dependent DNA helicase; Belongs to the helicase family. (168 aa)
	Esi_0231_0014	Putative, spindle assembly abnormal protein 6. (734 aa)
	Esi_0235_0039	ATP-dependent DNA helicase; Belongs to the helicase family. (1822 aa)
	Esi_0276_0016	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (759 aa)
	Esi_0279_0024	Replication protein A subunit. (419 aa)
	Esi_0279_0025	Rep-A_N domain-containing protein. (212 aa)
	Esi_0003_0205	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (161 aa)
	Esi_0158_0014	Helicase ATP-binding domain-containing protein. (572 aa)
	Esi_0131_0063	Helicase ATP-binding domain-containing protein. (301 aa)
	Esi_0131_0062	Helicase ATP-binding domain-containing protein. (932 aa)
	Esi_0013_0049	FHA domain-containing protein. (808 aa)
	Esi_0126_0044	DNA topoisomerase I (Partial). (1050 aa)
	Esi_0121_0044	Uncharacterized protein. (815 aa)
	BRCA2	Breast cancer 2 like. (4283 aa)
	Esi_0011_0063	ATP-dependent DNA helicase; Belongs to the helicase family. (1296 aa)
	Esi_0010_0212	Uncharacterized protein. (219 aa)
	Esi_0010_0200	RING-type domain-containing protein. (139 aa)
	Esi_0097_0076	Uncharacterized protein. (304 aa)
	Esi_0092_0039	Rad51 homolog C. (344 aa)
	Esi_0088_0014	DEAD box helicase. (2200 aa)
	Esi_0080_0023	Uncharacterized protein. (1552 aa)
	Esi_0008_0166	DNA topoisomerase I. (119 aa)
	Esi_0073_0118	DNA polymerase. (1097 aa)
	Esi_0067_0019	Uncharacterized protein; Belongs to the RecA family. (329 aa)
	Esi_0653_0001	ATP-dependent DNA helicase; Belongs to the helicase family. (435 aa)
	Rad51A	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily. (343 aa)
	Esi_0533_0015	ERCC4 domain containing protein. (416 aa)
	Esi_0531_0008	ATP-dependent DNA helicase; Belongs to the helicase family. (2154 aa)
	Esi_0033_0067	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (807 aa)
	Esi_0034_0087	Uncharacterized protein; Belongs to the RecA family. (146 aa)
	Esi_0034_0089	Meiotic recombination protein DMC1/LIM15 homolog, putative. (251 aa)
	RAD54	DNA repair and recombination protein RAD54 homolog. (1510 aa)
	Esi_0362_0005	Uncharacterized protein. (508 aa)
	Esi_0363_0019	ATP-dependent DNA helicase; Belongs to the helicase family. (302 aa)
	Esi_0373_0002	ATP-dependent DNA helicase; Belongs to the helicase family. (652 aa)
	Esi_0379_0021	DEAD box helicase. (774 aa)
	Esi_0400_0014	annotation not available (1533 aa)
	Esi_0045_0024	Uncharacterized protein. (1925 aa)
	Esi_0046_0089	Major facilitator superfamily permease. (714 aa)
	Esi_0465_0002	AAA_23 domain-containing protein. (442 aa)
	Esi_0477_0017	Uncharacterized protein. (466 aa)
	Esi_0050_0076	ATP-dependent DNA helicase; Belongs to the helicase family. (823 aa)
	Esi_0051_0111	G-patch domain-containing protein. (1097 aa)

Your Current Organism:

Ectocarpus siliculosus

NCBI taxonomy Id: 2880
Other names: E. siliculosus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRCA2	DNA-2	D8LCN1	D8LPC4	Breast cancer 2 like.	DNA polymerase.	0.556
BRCA2	Esi_0002_0181	D8LCN1	D7FQ61	Breast cancer 2 like.	annotation not available	0.951
BRCA2	Esi_0006_0201	D8LCN1	D8LQM7	Breast cancer 2 like.	ERCC4 domain containing protein.	0.641
BRCA2	Esi_0008_0166	D8LCN1	D7G723	Breast cancer 2 like.	DNA topoisomerase I.	0.706
BRCA2	Esi_0010_0200	D8LCN1	D8LC67	Breast cancer 2 like.	RING-type domain-containing protein.	0.870
BRCA2	Esi_0021_0019	D8LCN1	D7FR28	Breast cancer 2 like.	DEAD box helicase.	0.572
BRCA2	Esi_0033_0067	D8LCN1	D7FXK3	Breast cancer 2 like.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.572
BRCA2	Esi_0034_0087	D8LCN1	D7FY85	Breast cancer 2 like.	Uncharacterized protein; Belongs to the RecA family.	0.916
BRCA2	Esi_0034_0089	D8LCN1	D7FY86	Breast cancer 2 like.	Meiotic recombination protein DMC1/LIM15 homolog, putative.	0.916
BRCA2	Esi_0041_0002	D8LCN1	D8LMQ5	Breast cancer 2 like.	Pol1-like DNA polymerase.	0.537
BRCA2	Esi_0041_0029	D8LCN1	D8LMS0	Breast cancer 2 like.	SNF2-related domain-containing protein.	0.418
BRCA2	Esi_0044_0029	D8LCN1	D8LNB3	Breast cancer 2 like.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.799
BRCA2	Esi_0044_0036	D8LCN1	D8LNB7	Breast cancer 2 like.	Phosphatidylinositol kinase (PIK-5); Belongs to the PI3/PI4-kinase family.	0.799
BRCA2	Esi_0045_0024	D8LCN1	D7G1G0	Breast cancer 2 like.	Uncharacterized protein.	0.870
BRCA2	Esi_0052_0197	D8LCN1	D8LPM7	Breast cancer 2 like.	Uncharacterized protein.	0.548
BRCA2	Esi_0052_0199	D8LCN1	D8LPM9	Breast cancer 2 like.	BRCT domain-containing protein.	0.870
BRCA2	Esi_0067_0019	D8LCN1	D7G5P5	Breast cancer 2 like.	Uncharacterized protein; Belongs to the RecA family.	0.963
BRCA2	Esi_0073_0118	D8LCN1	D7G6D3	Breast cancer 2 like.	DNA polymerase.	0.556
BRCA2	Esi_0080_0023	D8LCN1	D7G795	Breast cancer 2 like.	Uncharacterized protein.	0.520
BRCA2	Esi_0088_0014	D8LCN1	D7G8A0	Breast cancer 2 like.	DEAD box helicase.	0.572