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gabD_1 gabD_1 maeB_1 maeB_1 fumC_1 fumC_1 fumB fumB aldA aldA glcB glcB citZ citZ ppc ppc SAI67803.1 SAI67803.1 acnB acnB bcpA bcpA acnA1 acnA1 ifcA_2 ifcA_2 maeB_2 maeB_2 gltA gltA SAI68343.1 SAI68343.1 sdhB sdhB sdhA sdhA sdhD sdhD sdhC_1 sdhC_1 mdh mdh prpB prpB prpC prpC acnA_1 acnA_1 mii_1 mii_1 prpD prpD bclA_1 bclA_1 acsA acsA betB_1 betB_1 icd icd icdA icdA mqo mqo citA citA frdB frdB SAI70899.1 SAI70899.1 sdhC_2 sdhC_2 ttdA ttdA ttdB ttdB mmsA_2 mmsA_2 Hgd_4 Hgd_4 SAI71055.1 SAI71055.1 pckG pckG feaB feaB sucD sucD sucC sucC aceA aceA acnA_2 acnA_2 goaG2 goaG2 gabD_2 gabD_2 SAI72839.1 SAI72839.1 SAI72856.1 SAI72856.1 fumC_2 fumC_2 glxR glxR prpE prpE mmsA_3 mmsA_3 fdxA fdxA bioA_2 bioA_2 fccA fccA maeB_3 maeB_3 poxB poxB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gabD_1Aldehyde dehydrogenase. (479 aa)
maeB_1NADP-dependent malic enzyme. (762 aa)
fumC_1Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (463 aa)
fumBFumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (507 aa)
aldAAldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (477 aa)
glcBMalate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (726 aa)
citZCitrate synthase. (264 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (950 aa)
SAI67803.1Indolepyruvate ferredoxin oxidoreductase. (1205 aa)
acnBBifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Belongs to the aconitase/IPM isomerase family. (863 aa)
bcpACarboxyvinyl-carboxyphosphonate phosphorylmutase. (295 aa)
acnA1Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (892 aa)
ifcA_2Fumarate reductase flavoprotein subunit. (468 aa)
maeB_2NADP-dependent malic enzyme. (760 aa)
gltACitrate synthase; Belongs to the citrate synthase family. (434 aa)
SAI68343.1Flavinator of succinate dehydrogenase. (86 aa)
sdhBSuccinate dehydrogenase iron-sulfur subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (238 aa)
sdhASuccinate dehydrogenase flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (592 aa)
sdhDSuccinate dehydrogenase hydrophobic membrane anchor protein. (126 aa)
sdhC_1Succinate dehydrogenase cytochrome B subunit. (137 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
prpB2-methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (297 aa)
prpC2-methylcitrate synthase; Belongs to the citrate synthase family. (418 aa)
acnA_1Aconitate hydratase. (889 aa)
mii_13-methylitaconate isomerase. (397 aa)
prpD2-methylcitrate dehydratase. (485 aa)
bclA_1AMP-binding protein. (557 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (659 aa)
betB_1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (335 aa)
icdIsocitrate dehydrogenase (NADP); Belongs to the monomeric-type IDH family. (742 aa)
icdAIsocitrate dehydrogenase. (418 aa)
mqoMalate:quinone oxidoreductase. (574 aa)
citACitrate synthase. (272 aa)
frdBFumarate reductase iron-sulfur protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (252 aa)
SAI70899.1Succinate dehydrogenase%2C hydrophobic membrane anchor protein. (111 aa)
sdhC_2Succinate dehydrogenase cytochrome b-556 subunit. (115 aa)
ttdAFumarate hydratase subunit alpha. (319 aa)
ttdBL-tartrate dehydratase%2C subunit B. (228 aa)
mmsA_2Methylmalonate-semialdehyde dehydrogenase. (504 aa)
Hgd_4Oxidoreductase. (307 aa)
SAI71055.1acetyl-CoA synthetase. (697 aa)
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (617 aa)
feaBAldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (487 aa)
sucDsuccinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (293 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (387 aa)
aceAIsocitrate lyase. (441 aa)
acnA_2Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (900 aa)
goaG24-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (418 aa)
gabD_2Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (490 aa)
SAI72839.1Pyruvate ferredoxin/flavodoxin oxidoreductase. (1169 aa)
SAI72856.1acyl-CoA synthetase. (817 aa)
fumC_2Fumarate hydratase class II. (377 aa)
glxR2-hydroxy-3-oxopropionate reductase. (300 aa)
prpEpropionate--CoA ligase. (629 aa)
mmsA_3Methylmalonate-semialdehyde dehydrogenase. (497 aa)
fdxAFerredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (107 aa)
bioA_2Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (454 aa)
fccADehydrogenase. (475 aa)
maeB_3NADP-dependent malic enzyme. (766 aa)
poxBThiamine pyrophosphate protein; Belongs to the TPP enzyme family. (588 aa)
Your Current Organism:
Bordetella ansorpii
NCBI taxonomy Id: 288768
Other names: B. ansorpii, strain SMC-8986
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