(15 nodes) Porphyrin biosynthesis, and Thiamine metabolic process network (Thermodesulfobacterium commune)

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Your Input:
	ribBA	3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (400 aa)
	hemL	Glutamate-1-semialdehyde aminotransferase; Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate; Derived by automated computational analysis using gene prediction method: Protein Homology. (430 aa)
	AIH03614.1	5-amino-6-(5-phosphoribosylamino)uracil reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (220 aa)
	AIH03723.1	Delta-aminolevulinic acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ALAD family. (325 aa)
	thiL	Hypothetical protein; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (314 aa)
	AIH03942.1	HemD protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (501 aa)
	hemC	Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (304 aa)
	AIH03944.1	FmdB family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (71 aa)
	AIH03969.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (71 aa)
	AIH04014.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (257 aa)
	AIH04126.1	Riboflavin synthase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (217 aa)
	ribH	6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (158 aa)
	hemA	glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (470 aa)
	thiC	Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (436 aa)
	thiE	Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (206 aa)

Your Current Organism:

Thermodesulfobacterium commune

NCBI taxonomy Id: 289377
Other names: T. commune DSM 2178, Thermodesulfobacterium commune DSM 2178

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIH03614.1	AIH04126.1	HL41_01570	HL41_04745	5-amino-6-(5-phosphoribosylamino)uracil reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Riboflavin synthase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.952
AIH03614.1	ribBA	HL41_01570	HL41_00245	5-amino-6-(5-phosphoribosylamino)uracil reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.	0.983
AIH03614.1	ribH	HL41_01570	HL41_06170	5-amino-6-(5-phosphoribosylamino)uracil reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.	0.833
AIH03723.1	AIH03942.1	HL41_02340	HL41_03640	Delta-aminolevulinic acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ALAD family.	HemD protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.993
AIH03723.1	hemA	HL41_02340	HL41_06555	Delta-aminolevulinic acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ALAD family.	glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).	0.748
AIH03723.1	hemC	HL41_02340	HL41_03645	Delta-aminolevulinic acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ALAD family.	Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.	0.995
AIH03723.1	hemL	HL41_02340	HL41_00480	Delta-aminolevulinic acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ALAD family.	Glutamate-1-semialdehyde aminotransferase; Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.991
AIH03723.1	ribBA	HL41_02340	HL41_00245	Delta-aminolevulinic acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ALAD family.	3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.	0.504
AIH03942.1	AIH03723.1	HL41_03640	HL41_02340	HemD protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Delta-aminolevulinic acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ALAD family.	0.993
AIH03942.1	AIH03944.1	HL41_03640	HL41_03650	HemD protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	FmdB family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.741
AIH03942.1	AIH03969.1	HL41_03640	HL41_03800	HemD protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.456
AIH03942.1	hemA	HL41_03640	HL41_06555	HemD protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).	0.887
AIH03942.1	hemC	HL41_03640	HL41_03645	HemD protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.	0.999
AIH03942.1	hemL	HL41_03640	HL41_00480	HemD protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Glutamate-1-semialdehyde aminotransferase; Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.774
AIH03942.1	ribBA	HL41_03640	HL41_00245	HemD protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.	0.579
AIH03942.1	thiC	HL41_03640	HL41_06710	HemD protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.	0.418
AIH03944.1	AIH03942.1	HL41_03650	HL41_03640	FmdB family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	HemD protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.741
AIH03944.1	hemC	HL41_03650	HL41_03645	FmdB family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.	0.760
AIH03969.1	AIH03942.1	HL41_03800	HL41_03640	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	HemD protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.456
AIH04014.1	ribBA	HL41_04090	HL41_00245	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.	0.417