STRINGSTRING
metG metG queC queC AIH03452.1 AIH03452.1 guaA guaA argS argS AIH03556.1 AIH03556.1 AIH03557.1 AIH03557.1 tilS tilS coaD coaD ileS ileS mnmA mnmA AIH03745.1 AIH03745.1 AIH03842.1 AIH03842.1 gltX gltX valS valS AIH03895.1 AIH03895.1 argG argG tyrS tyrS AIH03951.1 AIH03951.1 nadE nadE leuS leuS cysS cysS AIH04388.1 AIH04388.1 nadD nadD AIH04405.1 AIH04405.1 cysS-2 cysS-2 AIH04651.1 AIH04651.1 AIH04653.1 AIH04653.1 AIH04743.1 AIH04743.1 AIH04751.1 AIH04751.1 AIH04772.1 AIH04772.1 panC panC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
metGmethionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (628 aa)
queC7-cyano-7-deazaguanine synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (229 aa)
AIH03452.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (320 aa)
guaAGMP synthase; Catalyzes the synthesis of GMP from XMP. (513 aa)
argSarginine--tRNA ligase; Catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (549 aa)
AIH03556.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (264 aa)
AIH03557.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (335 aa)
tilSHypothetical protein; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (455 aa)
coaDPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (167 aa)
ileSisoleucine--tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (933 aa)
mnmAHypothetical protein; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (338 aa)
AIH03745.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (287 aa)
AIH03842.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (435 aa)
gltXglutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (468 aa)
valSvalyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (879 aa)
AIH03895.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (139 aa)
argGArgininosuccinate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (400 aa)
tyrStyrosine--tRNA ligase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. (402 aa)
AIH03951.1tryptophan--tRNA ligase; Catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I aminoacyl-tRNA synthetase family. (331 aa)
nadEHypothetical protein; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (559 aa)
leuSleucyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I aminoacyl-tRNA synthetase family. (861 aa)
cysScysteine--tRNA ligase; Catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I aminoacyl-tRNA synthetase family. (489 aa)
AIH04388.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (152 aa)
nadDHypothetical protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (210 aa)
AIH04405.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (135 aa)
cysS-2cysteinyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I aminoacyl-tRNA synthetase family. (773 aa)
AIH04651.1Universal stress protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (307 aa)
AIH04653.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (263 aa)
AIH04743.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (286 aa)
AIH04751.1Sulfate adenylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (457 aa)
AIH04772.1Glycerol-3-phosphate cytidylyltransferase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. (148 aa)
panCPantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (282 aa)
Your Current Organism:
Thermodesulfobacterium commune
NCBI taxonomy Id: 289377
Other names: T. commune DSM 2178, Thermodesulfobacterium commune DSM 2178
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.