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napD napD napA napA CKO_00570 CKO_00570 CKO_00571 CKO_00571 CKO_00572 CKO_00572 CKO_00573 CKO_00573 ccmA ccmA CKO_00575 CKO_00575 ccmC ccmC CKO_00578 CKO_00578 ccmE ccmE CKO_00581 CKO_00581 CKO_00582 CKO_00582 CKO_00583 CKO_00583 CKO_01225 CKO_01225 moaA moaA CKO_01289 CKO_01289 CKO_01290 CKO_01290 CKO_01291 CKO_01291 CKO_01292 CKO_01292 CKO_01293 CKO_01293 CKO_01294 CKO_01294 CKO_01299 CKO_01299 CKO_01300 CKO_01300 CKO_01301 CKO_01301 CKO_01302 CKO_01302 CKO_01303 CKO_01303 CKO_01304 CKO_01304 CKO_01305 CKO_01305 CKO_01306 CKO_01306 CKO_01366 CKO_01366 CKO_01500 CKO_01500 CKO_01501 CKO_01501 CKO_01502 CKO_01502 CKO_01503 CKO_01503 CKO_01504 CKO_01504 CKO_01514 CKO_01514 CKO_01515 CKO_01515 CKO_01581 CKO_01581 CKO_01582 CKO_01582 CKO_01583 CKO_01583 CKO_01584 CKO_01584 dmsD dmsD selD selD CKO_01828 CKO_01828 CKO_01829 CKO_01829 CKO_02174 CKO_02174 CKO_02175 CKO_02175 CKO_02177 CKO_02177 hcp hcp CKO_02282 CKO_02282 CKO_02283 CKO_02283 CKO_02340 CKO_02340 CKO_02341 CKO_02341 CKO_02342 CKO_02342 moaC moaC CKO_02344 CKO_02344 moaA-2 moaA-2 modC modC CKO_02371 CKO_02371 CKO_02372 CKO_02372 CKO_02374 CKO_02374 CKO_02375 CKO_02375 selU selU CKO_02670 CKO_02670 CKO_03090 CKO_03090 CKO_03110 CKO_03110 fdhD fdhD CKO_03116 CKO_03116 CKO_03117 CKO_03117 CKO_03118 CKO_03118 CKO_03119 CKO_03119 fdhE fdhE mobA mobA CKO_03158 CKO_03158 CKO_03377 CKO_03377 CKO_03807 CKO_03807 CKO_03808 CKO_03808 CKO_03809 CKO_03809 CKO_03810 CKO_03810 CKO_03811 CKO_03811 CKO_03812 CKO_03812 nrfA nrfA CKO_03815 CKO_03815 CKO_04380 CKO_04380 CKO_04382 CKO_04382 CKO_04789 CKO_04789 CKO_04790 CKO_04790 CKO_05002 CKO_05002 CKO_05046 CKO_05046 selA selA
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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Predicted Interactions
gene neighborhood
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napDHypothetical protein; Chaperone for NapA, the catalytic subunit of the periplasmic nitrate reductase. It binds directly and specifically to the twin- arginine signal peptide of NapA, preventing premature interaction with the Tat translocase and premature export. (88 aa)
napAHypothetical protein; Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite. (828 aa)
CKO_00570Hypothetical protein; KEGG: eci:UTI89_C2483 6.6e-112 napG; ferredoxin-type protein, subunit of nitrate reductase, periplasmic K02573; COG: COG1145 Ferredoxin. (214 aa)
CKO_00571Hypothetical protein; KEGG: eci:UTI89_C2482 3.3e-149 napH; ferredoxin-type protein K02574; COG: COG0348 Polyferredoxin; Psort location: CytoplasmicMembrane, score:10.00. (287 aa)
CKO_00572Hypothetical protein; Electron transfer subunit of the periplasmic nitrate reductase complex NapAB; Belongs to the NapB family. (156 aa)
CKO_00573Hypothetical protein; KEGG: eci:UTI89_C2480 3.7e-102 napC; cytochrome c protein, subunit of nitrate reductase, periplasmic K02569; COG: COG3005 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit; Psort location: CytoplasmicMembrane, score:8.02. (200 aa)
ccmAHypothetical protein; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. (206 aa)
CKO_00575Hypothetical protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmB/CycW/HelB family. (219 aa)
ccmCHypothetical protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family. (245 aa)
CKO_00578Hypothetical protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmD/CycX/HelD family. (70 aa)
ccmEHypothetical protein; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family. (159 aa)
CKO_00581Hypothetical protein; KEGG: vfi:VF1819 8.0e-226 heme chaperone--apocytochrome heme-lyase K02198; COG: COG1138 Cytochrome c biogenesis factor; Psort location: CytoplasmicMembrane, score:10.00. (647 aa)
CKO_00582KEGG: azo:azo3929 3.3e-30 ccmG; protein disulfide-isomerase K01829; COG: COG0526 Thiol-disulfide isomerase and thioredoxins; Psort location: Periplasmic, score:9.76. (185 aa)
CKO_00583Hypothetical protein; Possible subunit of a heme lyase. (349 aa)
CKO_01225Hypothetical protein; KEGG: bur:Bcep18194_C6997 0. oxidoreductase alpha (molybdopterin) subunit K00122; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (762 aa)
moaAHypothetical protein; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (328 aa)
CKO_01289Hypothetical protein; KEGG: xac:XAC2157 0.0030 cysG; uroporphyrin-III C-methyltransferase K02302; COG: COG3707 Response regulator with putative antiterminator output domain; Psort location: Cytoplasmic, score:8.96. (398 aa)
CKO_01290Hypothetical protein; COG: COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components. (400 aa)
CKO_01291Hypothetical protein; KEGG: rha:RHA1_ro08170 7.7e-22 ABC transporter, permease component; COG: COG0600 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component; Psort location: CytoplasmicMembrane, score:10.00. (293 aa)
CKO_01292Hypothetical protein; KEGG: azo:azo0944 4.0e-89 nasD; putative nitrate transport system, ATP-binding protein; COG: COG1116 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component; Psort location: Cytoplasmic, score:9.12. (262 aa)
CKO_01293Hypothetical protein; KEGG: eca:ECA2991 0. nasB; nitrite reductase [NAD(P)H] large subunit K00362; COG: COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases; Psort location: Cytoplasmic, score:9.26; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (1355 aa)
CKO_01294Hypothetical protein; KEGG: eca:ECA2990 1.7e-264 nasA; nitrate reductase K00372; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. (870 aa)
CKO_01299Hypothetical protein; COG: COG2223 Nitrate/nitrite transporter; Psort location: CytoplasmicMembrane, score:10.00. (411 aa)
CKO_01300Hypothetical protein. (70 aa)
CKO_01301Hypothetical protein; KEGG: spt:SPA1109 0. narG; respiratory nitrate reductase 1 alpha chain K00370; COG: COG5013 Nitrate reductase alpha subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1247 aa)
CKO_01302Hypothetical protein; KEGG: stt:t1672 2.2e-285 narH; respiratory nitrate reductase 1 beta chain K00371; COG: COG1140 Nitrate reductase beta subunit; Psort location: Cytoplasmic, score:9.26. (511 aa)
CKO_01303Hypothetical protein; KEGG: spt:SPA1111 1.0e-115 narJ; respiratory nitrate reductase 1 delta chain K00373; COG: COG2180 Nitrate reductase delta subunit; Psort location: Cytoplasmic, score:8.96. (236 aa)
CKO_01304Hypothetical protein; KEGG: stm:STM1761 1.0e-115 narI; nitrate reductase gamma chain K00374; COG: COG2181 Nitrate reductase gamma subunit; Psort location: CytoplasmicMembrane, score:10.00. (225 aa)
CKO_01305Hypothetical protein. (53 aa)
CKO_01306Hypothetical protein. (53 aa)
CKO_01366Hypothetical protein; KEGG: afu:AF1036 0.0024 chemotaxis histidine kinase, putative; COG: COG0023 Translation initiation factor 1 (eIF-1/SUI1) and related proteins; Psort location: Cytoplasmic, score:8.96. (108 aa)
CKO_01500Hypothetical protein; KEGG: eci:UTI89_C1683 3.1e-114 narV; respiratory nitrate reductase 2 gamma chain K08347; COG: COG2181 Nitrate reductase gamma subunit; Psort location: CytoplasmicMembrane, score:10.00. (226 aa)
CKO_01501Hypothetical protein; KEGG: sty:STY1486 8.9e-108 narW; respiratory nitrate reductase 2 delta chain K08361; COG: COG2180 Nitrate reductase delta subunit. (231 aa)
CKO_01502Hypothetical protein; KEGG: spt:SPA1290 3.7e-283 narY; respiratory nitrate reductase 2 beta chain K08346; COG: COG1140 Nitrate reductase beta subunit; Psort location: Cytoplasmic, score:9.26. (514 aa)
CKO_01503Hypothetical protein; KEGG: stm:STM1577 0. narZ; nitrate reductase alpha chain K08345; COG: COG5013 Nitrate reductase alpha subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1246 aa)
CKO_01504Hypothetical protein; COG: COG2223 Nitrate/nitrite transporter; Psort location: CytoplasmicMembrane, score:10.00. (464 aa)
CKO_01514Hypothetical protein; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. (294 aa)
CKO_01515Hypothetical protein; KEGG: stm:STM1568 4.3e-115 fdnI; formate dehydrogenase, cytochrome b556 subunit (formate dehydrogenase gamma subunit) K08350; COG: COG2864 Cytochrome b subunit of formate dehydrogenase; Psort location: CytoplasmicMembrane, score:10.00. (218 aa)
CKO_01581Hypothetical protein; KEGG: stm:STM1499 0. putative dimethyl sulphoxide reductase, chain A1 K07309; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: Periplasmic, score:9.76; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (809 aa)
CKO_01582Hypothetical protein; KEGG: stm:STM1498 0. putative dimethyl sulphoxide reductase K07310; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: Periplasmic, score:9.76; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (811 aa)
CKO_01583Hypothetical protein; KEGG: ecp:ECP_0909 2.4e-114 anaerobic dimethyl sulfoxide reductase, subunit B K07307; COG: COG0437 Fe-S-cluster-containing hydrogenase components 1; Psort location: CytoplasmicMembrane, score:7.88. (205 aa)
CKO_01584Hypothetical protein; KEGG: eci:UTI89_C1777 2.8e-127 ynfH; anaerobic dimethyl sulfoxide reductase chain YnfH K07312; COG: COG3302 DMSO reductase anchor subunit; Psort location: CytoplasmicMembrane, score:10.00. (285 aa)
dmsDHypothetical protein; Required for biogenesis/assembly of DMSO reductase, but not for the interaction of the DmsA signal peptide with the Tat system. May be part of a chaperone cascade complex that facilitates a folding- maturation pathway for the substrate protein. (193 aa)
selDHypothetical protein; Synthesizes selenophosphate from selenide and ATP. (349 aa)
CKO_01828Hypothetical protein; KEGG: eci:UTI89_C2076 0. bisZ; trimethylamine-N-oxide reductase 2 precursor K07812; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: Periplasmic, score:10.00. (821 aa)
CKO_01829Hypothetical protein; KEGG: eci:UTI89_C2480 7.4e-33 napC; cytochrome c protein, subunit of nitrate reductase, periplasmic K02569; COG: COG3005 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit; Psort location: CytoplasmicMembrane, score:8.02. (320 aa)
CKO_02174Hypothetical protein; KEGG: ecp:ECP_0910 2.7e-129 anaerobic dimethyl sulfoxide reductase, subunit C K07308; COG: COG3302 DMSO reductase anchor subunit; Psort location: CytoplasmicMembrane, score:10.00. (277 aa)
CKO_02175Hypothetical protein; KEGG: ecp:ECP_0909 2.8e-49 anaerobic dimethyl sulfoxide reductase, subunit B K07307; COG: COG0437 Fe-S-cluster-containing hydrogenase components 1. (99 aa)
CKO_02177Hypothetical protein; KEGG: sec:SC0918 0. dmsA; anaerobic dimethyl sulfoxide reductase, subunit A K07306; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: Periplasmic, score:9.76; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (814 aa)
hcpHypothetical protein; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. (562 aa)
CKO_02282Hypothetical protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (411 aa)
CKO_02283Hypothetical protein; KEGG: eci:UTI89_C0829 1.6e-117 moeB; molybdopterin biosynthesis protein MoeB K03751; COG: COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2. (255 aa)
CKO_02340COG: COG0670 Integral membrane protein, interacts with FtsH; Psort location: CytoplasmicMembrane, score:10.00; Belongs to the BI1 family. (249 aa)
CKO_02341Hypothetical protein; COG: COG0314 Molybdopterin converting factor, large subunit; Psort location: Cytoplasmic, score:8.96. (150 aa)
CKO_02342Hypothetical protein; COG: COG1977 Molybdopterin converting factor, small subunit. (81 aa)
moaCHypothetical protein; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (161 aa)
CKO_02344Hypothetical protein; May be involved in the biosynthesis of molybdopterin. Belongs to the MoaB/Mog family. (170 aa)
moaA-2Hypothetical protein; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (340 aa)
modCHypothetical protein; Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Molybdate importer (TC 3.A.1.8) family. (352 aa)
CKO_02371Hypothetical protein; Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (229 aa)
CKO_02372Hypothetical protein; COG: COG0725 ABC-type molybdate transport system, periplasmic component; Psort location: Periplasmic, score:10.00. (257 aa)
CKO_02374Hypothetical protein; KEGG: vfi:VF2163 0.0042 ATP-dependent helicase HrpB K03579; COG: COG2005 N-terminal domain of molybdenum-binding protein. (262 aa)
CKO_02375Hypothetical protein; KEGG: yps:YPTB1173 2.5e-199 modF, phrA; ABC molybdenum transporter, ATP-binding subunit modF K02017; COG: COG1119 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA; Psort location: CytoplasmicMembrane, score:7.88. (494 aa)
selUHypothetical protein; Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2- selenouridine (Se2U-RNA). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain. (360 aa)
CKO_02670Hypothetical protein; KEGG: pca:Pcar_2776 0.00019 2-acyl-glycerophospho-ethanolamine acyltransferase K05939:K01909; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: CytoplasmicMembrane, score:10.00. (406 aa)
CKO_03090COG: COG2258 Uncharacterized protein conserved in bacteria. (223 aa)
CKO_03110Hypothetical protein; COG: NOG13870 non supervised orthologous group. (70 aa)
fdhDHypothetical protein; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (243 aa)
CKO_03116Hypothetical protein; KEGG: ecs:ECs4820 6.0e-102 formate dehydrogenase-O major subunit K00123; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: Periplasmic, score:9.76. (195 aa)
CKO_03117Hypothetical protein; KEGG: sty:STY3839 0. fdoG; formate dehydrogenase-O, major subunit K00123; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: Periplasmic, score:9.44; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (804 aa)
CKO_03118Hypothetical protein; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. (300 aa)
CKO_03119Hypothetical protein; KEGG: sec:SC3925 4.6e-111 fdoI; formate dehydrogenase, cytochrome b556 (FDO) subunit K00127; COG: COG2864 Cytochrome b subunit of formate dehydrogenase; Psort location: CytoplasmicMembrane, score:10.00. (211 aa)
fdhEHypothetical protein; Necessary for formate dehydrogenase activity. Belongs to the FdhE family. (309 aa)
mobAHypothetical protein; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (194 aa)
CKO_03158Hypothetical protein; COG: COG1763 Molybdopterin-guanine dinucleotide biosynthesis protein. (167 aa)
CKO_03377Hypothetical protein; KEGG: hpa:HPAG1_0784 1.9e-41 molybdopterin biosynthesis protein; COG: COG0521 Molybdopterin biosynthesis enzymes; Psort location: Cytoplasmic, score:8.96. (195 aa)
CKO_03807Hypothetical protein; KEGG: eci:UTI89_C4062 2.0e-06 yhjL; cellulose synthase operon protein C K00694; COG: COG4235 Cytochrome c biogenesis factor. (233 aa)
CKO_03808Hypothetical protein; Possible subunit of a heme lyase. (163 aa)
CKO_03809Hypothetical protein; KEGG: stm:STM4281 1.2e-253 nrfE; putative methylase K04016; COG: COG1138 Cytochrome c biogenesis factor; Psort location: CytoplasmicMembrane, score:10.00. (555 aa)
CKO_03810Hypothetical protein; KEGG: pai:PAE2861 9.2e-19 molybdopterin oxidoreductase, membrane subunit K00185; COG: COG3301 Formate-dependent nitrite reductase, membrane component; Psort location: CytoplasmicMembrane, score:10.00. (318 aa)
CKO_03811Hypothetical protein; KEGG: vfi:VF1552 4.8e-77 thiosulfate reductase electron transport subunit K04014; COG: COG0437 Fe-S-cluster-containing hydrogenase components 1. (223 aa)
CKO_03812Hypothetical protein; KEGG: pmu:PM0023 0.0014 nrfA; nitrite reductase periplasmic cytochrome c552 K03385; COG: NOG06794 non supervised orthologous group. (190 aa)
nrfAHypothetical protein; Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process; Belongs to the cytochrome c-552 family. (478 aa)
CKO_03815Hypothetical protein. (38 aa)
CKO_04380Hypothetical protein; KEGG: eci:UTI89_C1715 3.3e-236 ydeP; hypothetical protein YdeP K00122; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (762 aa)
CKO_04382Hypothetical protein; COG: COG0725 ABC-type molybdate transport system, periplasmic component. (227 aa)
CKO_04789Hypothetical protein; KEGG: stm:STM3474 0. nirB; nitrite reductase, large subunit K00362; COG: COG1251 NAD(P)H-nitrite reductase; Psort location: Cytoplasmic, score:9.97; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (847 aa)
CKO_04790Hypothetical protein; KEGG: sfl:SF3385 3.8e-52 nirD; nitrite reductase (NAD(P)H) subunit K00363; COG: COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases; Psort location: Cytoplasmic, score:9.97. (108 aa)
CKO_05002Hypothetical protein; KEGG: stm:STM3644 0. bisC; biotin sulfoxide reductase K08351; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: Periplasmic, score:9.44; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (644 aa)
CKO_05046Hypothetical protein; KEGG: eci:UTI89_C4132 3.2e-286 selB; selenocysteine-specific elongation factor K03833; COG: COG3276 Selenocysteine-specific translation elongation factor. (615 aa)
selAHypothetical protein; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis; Belongs to the SelA family. (481 aa)
Your Current Organism:
Citrobacter koseri
NCBI taxonomy Id: 290338
Other names: C. koseri ATCC BAA-895, Citrobacter (diversus) koseri ATCC BAA-895, Citrobacter koseri ATCC BAA-895, Citrobacter koseri str. ATCC BAA-895, Citrobacter koseri strain ATCC BAA-895
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