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napD napD napA napA CKO_00570 CKO_00570 CKO_00571 CKO_00571 CKO_00572 CKO_00572 CKO_00573 CKO_00573 ccmA ccmA CKO_00575 CKO_00575 ccmC ccmC CKO_00578 CKO_00578 ccmE ccmE CKO_00581 CKO_00581 CKO_00582 CKO_00582 CKO_00583 CKO_00583 CKO_01225 CKO_01225 CKO_01366 CKO_01366 CKO_01514 CKO_01514 CKO_01515 CKO_01515 CKO_01581 CKO_01581 CKO_01582 CKO_01582 CKO_01583 CKO_01583 CKO_01584 CKO_01584 dmsD dmsD selD selD CKO_01828 CKO_01828 CKO_01829 CKO_01829 CKO_02174 CKO_02174 CKO_02175 CKO_02175 CKO_02177 CKO_02177 selU selU CKO_03116 CKO_03116 CKO_03117 CKO_03117 CKO_03118 CKO_03118 CKO_03119 CKO_03119 fdhE fdhE CKO_03807 CKO_03807 CKO_03808 CKO_03808 CKO_03809 CKO_03809 CKO_03810 CKO_03810 CKO_03811 CKO_03811 CKO_03812 CKO_03812 nrfA nrfA CKO_03815 CKO_03815 CKO_05002 CKO_05002 CKO_05046 CKO_05046 selA selA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
napDHypothetical protein; Chaperone for NapA, the catalytic subunit of the periplasmic nitrate reductase. It binds directly and specifically to the twin- arginine signal peptide of NapA, preventing premature interaction with the Tat translocase and premature export. (88 aa)
napAHypothetical protein; Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite. (828 aa)
CKO_00570Hypothetical protein; KEGG: eci:UTI89_C2483 6.6e-112 napG; ferredoxin-type protein, subunit of nitrate reductase, periplasmic K02573; COG: COG1145 Ferredoxin. (214 aa)
CKO_00571Hypothetical protein; KEGG: eci:UTI89_C2482 3.3e-149 napH; ferredoxin-type protein K02574; COG: COG0348 Polyferredoxin; Psort location: CytoplasmicMembrane, score:10.00. (287 aa)
CKO_00572Hypothetical protein; Electron transfer subunit of the periplasmic nitrate reductase complex NapAB; Belongs to the NapB family. (156 aa)
CKO_00573Hypothetical protein; KEGG: eci:UTI89_C2480 3.7e-102 napC; cytochrome c protein, subunit of nitrate reductase, periplasmic K02569; COG: COG3005 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit; Psort location: CytoplasmicMembrane, score:8.02. (200 aa)
ccmAHypothetical protein; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. (206 aa)
CKO_00575Hypothetical protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmB/CycW/HelB family. (219 aa)
ccmCHypothetical protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family. (245 aa)
CKO_00578Hypothetical protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmD/CycX/HelD family. (70 aa)
ccmEHypothetical protein; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family. (159 aa)
CKO_00581Hypothetical protein; KEGG: vfi:VF1819 8.0e-226 heme chaperone--apocytochrome heme-lyase K02198; COG: COG1138 Cytochrome c biogenesis factor; Psort location: CytoplasmicMembrane, score:10.00. (647 aa)
CKO_00582KEGG: azo:azo3929 3.3e-30 ccmG; protein disulfide-isomerase K01829; COG: COG0526 Thiol-disulfide isomerase and thioredoxins; Psort location: Periplasmic, score:9.76. (185 aa)
CKO_00583Hypothetical protein; Possible subunit of a heme lyase. (349 aa)
CKO_01225Hypothetical protein; KEGG: bur:Bcep18194_C6997 0. oxidoreductase alpha (molybdopterin) subunit K00122; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (762 aa)
CKO_01366Hypothetical protein; KEGG: afu:AF1036 0.0024 chemotaxis histidine kinase, putative; COG: COG0023 Translation initiation factor 1 (eIF-1/SUI1) and related proteins; Psort location: Cytoplasmic, score:8.96. (108 aa)
CKO_01514Hypothetical protein; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. (294 aa)
CKO_01515Hypothetical protein; KEGG: stm:STM1568 4.3e-115 fdnI; formate dehydrogenase, cytochrome b556 subunit (formate dehydrogenase gamma subunit) K08350; COG: COG2864 Cytochrome b subunit of formate dehydrogenase; Psort location: CytoplasmicMembrane, score:10.00. (218 aa)
CKO_01581Hypothetical protein; KEGG: stm:STM1499 0. putative dimethyl sulphoxide reductase, chain A1 K07309; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: Periplasmic, score:9.76; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (809 aa)
CKO_01582Hypothetical protein; KEGG: stm:STM1498 0. putative dimethyl sulphoxide reductase K07310; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: Periplasmic, score:9.76; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (811 aa)
CKO_01583Hypothetical protein; KEGG: ecp:ECP_0909 2.4e-114 anaerobic dimethyl sulfoxide reductase, subunit B K07307; COG: COG0437 Fe-S-cluster-containing hydrogenase components 1; Psort location: CytoplasmicMembrane, score:7.88. (205 aa)
CKO_01584Hypothetical protein; KEGG: eci:UTI89_C1777 2.8e-127 ynfH; anaerobic dimethyl sulfoxide reductase chain YnfH K07312; COG: COG3302 DMSO reductase anchor subunit; Psort location: CytoplasmicMembrane, score:10.00. (285 aa)
dmsDHypothetical protein; Required for biogenesis/assembly of DMSO reductase, but not for the interaction of the DmsA signal peptide with the Tat system. May be part of a chaperone cascade complex that facilitates a folding- maturation pathway for the substrate protein. (193 aa)
selDHypothetical protein; Synthesizes selenophosphate from selenide and ATP. (349 aa)
CKO_01828Hypothetical protein; KEGG: eci:UTI89_C2076 0. bisZ; trimethylamine-N-oxide reductase 2 precursor K07812; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: Periplasmic, score:10.00. (821 aa)
CKO_01829Hypothetical protein; KEGG: eci:UTI89_C2480 7.4e-33 napC; cytochrome c protein, subunit of nitrate reductase, periplasmic K02569; COG: COG3005 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit; Psort location: CytoplasmicMembrane, score:8.02. (320 aa)
CKO_02174Hypothetical protein; KEGG: ecp:ECP_0910 2.7e-129 anaerobic dimethyl sulfoxide reductase, subunit C K07308; COG: COG3302 DMSO reductase anchor subunit; Psort location: CytoplasmicMembrane, score:10.00. (277 aa)
CKO_02175Hypothetical protein; KEGG: ecp:ECP_0909 2.8e-49 anaerobic dimethyl sulfoxide reductase, subunit B K07307; COG: COG0437 Fe-S-cluster-containing hydrogenase components 1. (99 aa)
CKO_02177Hypothetical protein; KEGG: sec:SC0918 0. dmsA; anaerobic dimethyl sulfoxide reductase, subunit A K07306; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: Periplasmic, score:9.76; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (814 aa)
selUHypothetical protein; Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2- selenouridine (Se2U-RNA). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain. (360 aa)
CKO_03116Hypothetical protein; KEGG: ecs:ECs4820 6.0e-102 formate dehydrogenase-O major subunit K00123; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: Periplasmic, score:9.76. (195 aa)
CKO_03117Hypothetical protein; KEGG: sty:STY3839 0. fdoG; formate dehydrogenase-O, major subunit K00123; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: Periplasmic, score:9.44; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (804 aa)
CKO_03118Hypothetical protein; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. (300 aa)
CKO_03119Hypothetical protein; KEGG: sec:SC3925 4.6e-111 fdoI; formate dehydrogenase, cytochrome b556 (FDO) subunit K00127; COG: COG2864 Cytochrome b subunit of formate dehydrogenase; Psort location: CytoplasmicMembrane, score:10.00. (211 aa)
fdhEHypothetical protein; Necessary for formate dehydrogenase activity. Belongs to the FdhE family. (309 aa)
CKO_03807Hypothetical protein; KEGG: eci:UTI89_C4062 2.0e-06 yhjL; cellulose synthase operon protein C K00694; COG: COG4235 Cytochrome c biogenesis factor. (233 aa)
CKO_03808Hypothetical protein; Possible subunit of a heme lyase. (163 aa)
CKO_03809Hypothetical protein; KEGG: stm:STM4281 1.2e-253 nrfE; putative methylase K04016; COG: COG1138 Cytochrome c biogenesis factor; Psort location: CytoplasmicMembrane, score:10.00. (555 aa)
CKO_03810Hypothetical protein; KEGG: pai:PAE2861 9.2e-19 molybdopterin oxidoreductase, membrane subunit K00185; COG: COG3301 Formate-dependent nitrite reductase, membrane component; Psort location: CytoplasmicMembrane, score:10.00. (318 aa)
CKO_03811Hypothetical protein; KEGG: vfi:VF1552 4.8e-77 thiosulfate reductase electron transport subunit K04014; COG: COG0437 Fe-S-cluster-containing hydrogenase components 1. (223 aa)
CKO_03812Hypothetical protein; KEGG: pmu:PM0023 0.0014 nrfA; nitrite reductase periplasmic cytochrome c552 K03385; COG: NOG06794 non supervised orthologous group. (190 aa)
nrfAHypothetical protein; Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process; Belongs to the cytochrome c-552 family. (478 aa)
CKO_03815Hypothetical protein. (38 aa)
CKO_05002Hypothetical protein; KEGG: stm:STM3644 0. bisC; biotin sulfoxide reductase K08351; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: Periplasmic, score:9.44; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (644 aa)
CKO_05046Hypothetical protein; KEGG: eci:UTI89_C4132 3.2e-286 selB; selenocysteine-specific elongation factor K03833; COG: COG3276 Selenocysteine-specific translation elongation factor. (615 aa)
selAHypothetical protein; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis; Belongs to the SelA family. (481 aa)
Your Current Organism:
Citrobacter koseri
NCBI taxonomy Id: 290338
Other names: C. koseri ATCC BAA-895, Citrobacter (diversus) koseri ATCC BAA-895, Citrobacter koseri ATCC BAA-895, Citrobacter koseri str. ATCC BAA-895, Citrobacter koseri strain ATCC BAA-895
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