STRINGSTRING
CKO_00064 CKO_00064 kup kup CKO_00192 CKO_00192 CKO_00240 CKO_00240 CKO_00243 CKO_00243 CKO_00276 CKO_00276 CKO_00384 CKO_00384 mntH mntH CKO_00612 CKO_00612 CKO_00615 CKO_00615 CKO_00631 CKO_00631 CKO_00650 CKO_00650 CKO_00837 CKO_00837 CKO_00872 CKO_00872 CKO_01064 CKO_01064 CKO_01081 CKO_01081 nhaB nhaB CKO_01196 CKO_01196 CKO_01270 CKO_01270 CKO_01281 CKO_01281 CKO_01394 CKO_01394 CKO_01495 CKO_01495 dtpA dtpA mdtK mdtK CKO_01755 CKO_01755 CKO_02041 CKO_02041 CKO_02414 CKO_02414 CKO_02422 CKO_02422 CKO_02448 CKO_02448 dtpD dtpD potE potE CKO_02563 CKO_02563 CKO_02581 CKO_02581 CKO_02650 CKO_02650 CKO_02671 CKO_02671 CKO_03045 CKO_03045 kdgT kdgT rhaT rhaT CKO_03136 CKO_03136 CKO_03137 CKO_03137 clcA clcA CKO_03263 CKO_03263 CKO_03309 CKO_03309 nepI nepI CKO_04987 CKO_04987 CKO_04225 CKO_04225 CKO_04419 CKO_04419 sstT sstT CKO_04511 CKO_04511 tdcC tdcC CKO_04599 CKO_04599 lplT lplT CKO_04160 CKO_04160 CKO_04152 CKO_04152 CKO_03900 CKO_03900 CKO_03895 CKO_03895 CKO_03870 CKO_03870 CKO_03824 CKO_03824 actP actP gltP gltP kdgT-2 kdgT-2 CKO_03734 CKO_03734 CKO_03624 CKO_03624 CKO_03455 CKO_03455 CKO_03443 CKO_03443 CKO_03379 CKO_03379 CKO_03375 CKO_03375 nhaA nhaA CKO_03359 CKO_03359 caiT caiT kefC kefC nanT nanT CKO_04669 CKO_04669 kefB kefB CKO_04941 CKO_04941 dtpB dtpB dctA dctA CKO_00026 CKO_00026 pstB pstB CKO_00063 CKO_00063
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CKO_00064Hypothetical protein; Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (319 aa)
kupHypothetical protein; Responsible for the low-affinity transport of potassium into the cell, with the probable concomitant uptake of protons (symport system); Belongs to the HAK/KUP transporter (TC 2.A.72) family. (622 aa)
CKO_00192Hypothetical protein; Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA; Belongs to the TrkH potassium transport family. (483 aa)
CKO_00240Hypothetical protein; KEGG: cal:orf19.644 1.2e-46 HXT4; high-affinity glucose transporter or sensor K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: CytoplasmicMembrane, score:10.00; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (479 aa)
CKO_00243Hypothetical protein; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: CytoplasmicMembrane, score:10.00. (379 aa)
CKO_00276Hypothetical protein; COG: COG3104 Dipeptide/tripeptide permease; Psort location: CytoplasmicMembrane, score:10.00. (517 aa)
CKO_00384Hypothetical protein; COG: COG0385 Predicted Na+-dependent transporter; Psort location: CytoplasmicMembrane, score:10.00. (332 aa)
mntHHypothetical protein; H(+)-stimulated, divalent metal cation uptake system. Belongs to the NRAMP family. (418 aa)
CKO_00612Hypothetical protein; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: CytoplasmicMembrane, score:10.00. (393 aa)
CKO_00615Hypothetical protein; KEGG: spt:SPA0647 2.8e-278 fruA; PTS system, fructose-specific IIBC component K02769:K02770; COG: COG1299 Phosphotransferase system, fructose-specific IIC component; Psort location: CytoplasmicMembrane, score:10.00. (563 aa)
CKO_00631Hypothetical protein; KEGG: shn:Shewana3_1692 0.0058 Xaa-His dipeptidase K01270; COG: COG2271 Sugar phosphate permease; Psort location: CytoplasmicMembrane, score:10.00. (440 aa)
CKO_00650Hypothetical protein; KEGG: cal:orf19.4384 8.9e-09 HXT10; fructose symporter K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: CytoplasmicMembrane, score:10.00. (475 aa)
CKO_00837Hypothetical protein; COG: COG0534 Na+-driven multidrug efflux pump; Psort location: CytoplasmicMembrane, score:10.00. (496 aa)
CKO_00872Hypothetical protein; KEGG: tfu:Tfu_2682 0.0012 proton-translocating NADH-quinone oxidoreductase, chain N K00343; COG: COG0534 Na+-driven multidrug efflux pump; Psort location: CytoplasmicMembrane, score:10.00. (479 aa)
CKO_01064Hypothetical protein; KEGG: eci:UTI89_C4668 1.1e-68 gltP; glutamate-aspartate symport protein K03309; COG: COG1301 Na+/H+-dicarboxylate symporters; Psort location: CytoplasmicMembrane, score:10.00; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. (422 aa)
CKO_01081Hypothetical protein; KEGG: eci:UTI89_C4210 2.0e-19 yicJ; hypothetical symporter YicJ K03292; COG: COG2211 Na+/melibiose symporter and related transporters; Psort location: CytoplasmicMembrane, score:10.00. (527 aa)
nhaBHypothetical protein; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family. (514 aa)
CKO_01196Hypothetical protein; COG: COG3263 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain; Psort location: CytoplasmicMembrane, score:10.00. (535 aa)
CKO_01270Hypothetical protein; KEGG: eci:UTI89_C1400 1.7e-271 ychM; putative sulfate transporter YchM K03321; COG: COG0659 Sulfate permease and related transporters (MFS superfamily); Psort location: CytoplasmicMembrane, score:10.00. (550 aa)
CKO_01281Hypothetical protein; COG: COG0387 Ca2+/H+ antiporter; Psort location: CytoplasmicMembrane, score:10.00. (366 aa)
CKO_01394Hypothetical protein; KEGG: eci:UTI89_C3355 0.00015 nupG; transport of nucleosides, permease protein K03289; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: CytoplasmicMembrane, score:10.00. (419 aa)
CKO_01495Hypothetical protein; KEGG: eci:UTI89_C0120 2.0e-85 aroP; aromatic amino acid transport protein AroP K03293; COG: COG1113 Gamma-aminobutyrate permease and related permeases; Psort location: CytoplasmicMembrane, score:10.00. (541 aa)
dtpAHypothetical protein; Proton-dependent permease that transports di- and tripeptides; Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpA subfamily. (560 aa)
mdtKHypothetical protein; Multidrug efflux pump that functions probably as a Na(+)/drug antiporter; Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily. (457 aa)
CKO_01755Hypothetical protein; KEGG: eci:UTI89_C4668 2.4e-36 gltP; glutamate-aspartate symport protein K03309; COG: COG1823 Predicted Na+/dicarboxylate symporter; Psort location: CytoplasmicMembrane, score:10.00; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. (463 aa)
CKO_02041Hypothetical protein; Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (544 aa)
CKO_02414Hypothetical protein; KEGG: eco:b0731 3.2e-293 hrsA; PTS family enzyme IIA (N-terminal); enzyme IIBC (C-terminal), induction of OmpC K02768:K02769:K02770; COG: COG1299 Phosphotransferase system, fructose-specific IIC component; Psort location: CytoplasmicMembrane, score:10.00. (639 aa)
CKO_02422Hypothetical protein; KEGG: eci:UTI89_C4668 5.6e-67 gltP; glutamate-aspartate symport protein K03309; COG: COG1301 Na+/H+-dicarboxylate symporters; Psort location: CytoplasmicMembrane, score:10.00; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. (435 aa)
CKO_02448Hypothetical protein; KEGG: eci:UTI89_C3355 1.2e-06 nupG; transport of nucleosides, permease protein K03289; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: CytoplasmicMembrane, score:10.00. (421 aa)
dtpDHypothetical protein; Probable proton-dependent permease that transports dipeptides; Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpD subfamily. (493 aa)
potEHypothetical protein; Catalyzes both the uptake and excretion of putrescine. The uptake of putrescine is dependent on the membrane potential and the excretion involves putrescine-ornithine antiporter activity. Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family. (439 aa)
CKO_02563Hypothetical protein; KEGG: xtr:3283503 0.0075 ND6; NADH dehydrogenase subunit 6 K03884; COG: COG1966 Carbon starvation protein, predicted membrane protein; Psort location: CytoplasmicMembrane, score:10.00. (701 aa)
CKO_02581Hypothetical protein; KEGG: shn:Shewana3_2719 6.6e-135 choline/carnitine/betaine transporter K01718; COG: COG1292 Choline-glycine betaine transporter; Psort location: CytoplasmicMembrane, score:10.00; Belongs to the BCCT transporter (TC 2.A.15) family. (677 aa)
CKO_02650Hypothetical protein; KEGG: lpn:lpg1141 1.6e-28 spermidine/putrescine ABC transporter, ATP-binding protein PotA K02052; COG: COG4619 ABC-type uncharacterized transport system, ATPase component; Psort location: CytoplasmicMembrane, score:7.88. (225 aa)
CKO_02671Hypothetical protein; KEGG: rpa:RPA0846 0.0037 atpB; Fo ATP synthase subunit A K02108; COG: COG1226 Kef-type K+ transport systems, predicted NAD-binding component; Psort location: CytoplasmicMembrane, score:10.00; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. (558 aa)
CKO_03045Hypothetical protein; KEGG: eci:UTI89_C4539 5.7e-177 frwC; PTS system fructose-like-2 IIC component K02770; COG: COG1299 Phosphotransferase system, fructose-specific IIC component; Psort location: CytoplasmicMembrane, score:10.00. (359 aa)
kdgTHypothetical protein; The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system. Belongs to the KdgT transporter family. (327 aa)
rhaTHypothetical protein; Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Belongs to the L-rhamnose transporter (TC 2.A.7.6) family. (344 aa)
CKO_03136Hypothetical protein; KEGG: eci:UTI89_C4210 4.7e-47 yicJ; hypothetical symporter YicJ K03292; COG: COG2211 Na+/melibiose symporter and related transporters; Psort location: CytoplasmicMembrane, score:10.00. (460 aa)
CKO_03137Hypothetical protein; KEGG: eci:UTI89_C4210 5.5e-44 yicJ; hypothetical symporter YicJ K03292; COG: COG2211 Na+/melibiose symporter and related transporters; Psort location: CytoplasmicMembrane, score:10.00. (464 aa)
clcAHypothetical protein; Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response. (473 aa)
CKO_03263Hypothetical protein; KEGG: eci:UTI89_C4210 1.3e-115 yicJ; hypothetical symporter YicJ K03292; COG: COG2211 Na+/melibiose symporter and related transporters; Psort location: CytoplasmicMembrane, score:10.00. (473 aa)
CKO_03309Hypothetical protein; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: CytoplasmicMembrane, score:10.00. (392 aa)
nepIHypothetical protein; Involved in the efflux of purine ribonucleosides, such as guanosine, adenosine and especially inosine. Involved in the resistance to 6-mercaptopurine; Belongs to the major facilitator superfamily. DHA1 family. NepI (TC 2.A.1.2.26) subfamily. (413 aa)
CKO_04987Hypothetical protein; COG: COG0814 Amino acid permeases; Psort location: CytoplasmicMembrane, score:10.00. (432 aa)
CKO_04225Hypothetical protein; COG: COG0814 Amino acid permeases; Psort location: CytoplasmicMembrane, score:10.00. (409 aa)
CKO_04419Hypothetical protein; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: CytoplasmicMembrane, score:10.00. (422 aa)
sstTHypothetical protein; Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system). Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. (414 aa)
CKO_04511Hypothetical protein; COG: COG0814 Amino acid permeases; Psort location: CytoplasmicMembrane, score:10.00. (461 aa)
tdcCHypothetical protein; Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system). Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily. (443 aa)
CKO_04599Hypothetical protein; COG: COG0530 Ca2+/Na+ antiporter; Psort location: CytoplasmicMembrane, score:10.00. (325 aa)
lplTHypothetical protein; Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell; Belongs to the major facilitator superfamily. LplT (TC 2.A.1.42) family. (398 aa)
CKO_04160Hypothetical protein; COG: COG0738 Fucose permease; Psort location: CytoplasmicMembrane, score:10.00. (436 aa)
CKO_04152Hypothetical protein; COG: COG0814 Amino acid permeases; Psort location: CytoplasmicMembrane, score:10.00. (429 aa)
CKO_03900Hypothetical protein; COG: COG1283 Na+/phosphate symporter; Psort location: CytoplasmicMembrane, score:10.00. (518 aa)
CKO_03895Hypothetical protein; COG: COG0385 Predicted Na+-dependent transporter; Psort location: CytoplasmicMembrane, score:10.00. (312 aa)
CKO_03870Hypothetical protein; COG: COG0534 Na+-driven multidrug efflux pump; Psort location: CytoplasmicMembrane, score:10.00. (439 aa)
CKO_03824Hypothetical protein; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (548 aa)
actPHypothetical protein; Transports acetate; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (549 aa)
gltPHypothetical protein; Catalyzes the proton-dependent transport of glutamate and aspartate; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. GltP subfamily. (449 aa)
kdgT-2Hypothetical protein; The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system. Belongs to the KdgT transporter family. (332 aa)
CKO_03734Hypothetical protein; KEGG: eci:UTI89_C4210 6.2e-13 yicJ; hypothetical symporter YicJ K03292; COG: COG2211 Na+/melibiose symporter and related transporters; Psort location: CytoplasmicMembrane, score:10.00. (514 aa)
CKO_03624Hypothetical protein; KEGG: eci:UTI89_C0120 3.7e-93 aroP; aromatic amino acid transport protein AroP K03293; COG: COG1113 Gamma-aminobutyrate permease and related permeases; Psort location: CytoplasmicMembrane, score:10.00. (469 aa)
CKO_03455Hypothetical protein; KEGG: eci:UTI89_C4668 9.3e-26 gltP; glutamate-aspartate symport protein K03309; COG: COG1301 Na+/H+-dicarboxylate symporters; Psort location: CytoplasmicMembrane, score:10.00; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. (416 aa)
CKO_03443COG: COG1966 Carbon starvation protein, predicted membrane protein; Psort location: CytoplasmicMembrane, score:10.00. (716 aa)
CKO_03379Hypothetical protein; KEGG: hpa:HPAG1_0925 1.4e-63 D-alanine glycine permease K01613; COG: COG1115 Na+/alanine symporter; Psort location: CytoplasmicMembrane, score:10.00. (478 aa)
CKO_03375Hypothetical protein; KEGG: dsy:DSY4088 0.0047 dmsC; putative anaerobic DMSO reductase chain C anchor subunit K00369; COG: COG1584 Predicted membrane protein; Psort location: CytoplasmicMembrane, score:9.46. (188 aa)
nhaAHypothetical protein; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family. (388 aa)
CKO_03359Hypothetical protein; Uptake of citrate across the boundary membrane with the concomitant uptake of a sodium ion (symport system). Belongs to the sodium:citrate (SCF) symporter family. (455 aa)
caiTHypothetical protein; Catalyzes the exchange of L-carnitine for gamma-butyrobetaine and related betaines. (505 aa)
kefCHypothetical protein; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. (620 aa)
nanTHypothetical protein; Catalyzes the proton-dependent transport of sialic acid. Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family. (496 aa)
CKO_04669Hypothetical protein; KEGG: rpr:RP465 2.8e-12 phoR; alkaline phosphatase synthesis sensor protein phoR K07636; COG: COG4145 Na+/panthothenate symporter; Psort location: CytoplasmicMembrane, score:10.00; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (484 aa)
kefBHypothetical protein; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. (601 aa)
CKO_04941Hypothetical protein; COG: COG0306 Phosphate/sulphate permeases; Psort location: CytoplasmicMembrane, score:10.00. (498 aa)
dtpBHypothetical protein; Proton-dependent permease that transports di- and tripeptides; Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpB subfamily. (490 aa)
dctAHypothetical protein; Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane. Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. (428 aa)
CKO_00026Hypothetical protein; COG: COG4146 Predicted symporter; Psort location: CytoplasmicMembrane, score:10.00; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (578 aa)
pstBHypothetical protein; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (257 aa)
CKO_00063Hypothetical protein; KEGG: syn:sll0739 7.8e-06 modBC; ABC-type molybdate transport system permease/ATP-binding protein K02018; COG: COG0581 ABC-type phosphate transport system, permease component; Psort location: CytoplasmicMembrane, score:10.00. (296 aa)
Your Current Organism:
Citrobacter koseri
NCBI taxonomy Id: 290338
Other names: C. koseri ATCC BAA-895, Citrobacter (diversus) koseri ATCC BAA-895, Citrobacter koseri ATCC BAA-895, Citrobacter koseri str. ATCC BAA-895, Citrobacter koseri strain ATCC BAA-895
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.