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CKO_02560 CKO_02560 tdh tdh gpsA gpsA mtlD mtlD CKO_05045 CKO_05045 dlgD dlgD ghrB ghrB CKO_04923 CKO_04923 aroE aroE mdh mdh garR garR CKO_04473 CKO_04473 CKO_04406 CKO_04406 CKO_04377 CKO_04377 CKO_04278 CKO_04278 CKO_04245 CKO_04245 CKO_04157 CKO_04157 CKO_03733 CKO_03733 CKO_03717 CKO_03717 CKO_03534 CKO_03534 CKO_03385 CKO_03385 pdxA pdxA leuB leuB dxr dxr CKO_03131 CKO_03131 CKO_03104 CKO_03104 CKO_00028 CKO_00028 ilvC ilvC wecC wecC fadB fadB guaB guaB CKO_00332 CKO_00332 CKO_00342 CKO_00342 fadJ fadJ pdxB pdxB CKO_00608 CKO_00608 CKO_00692 CKO_00692 fcl fcl CKO_00756 CKO_00756 CKO_00757 CKO_00757 hisD hisD CKO_00784 CKO_00784 CKO_00862 CKO_00862 zwf zwf CKO_01178 CKO_01178 CKO_01318 CKO_01318 CKO_01429 CKO_01429 CKO_01455 CKO_01455 maeA maeA uxaB uxaB ldh ldh CKO_01569 CKO_01569 CKO_01572 CKO_01572 CKO_01759 CKO_01759 CKO_01835 CKO_01835 CKO_01965 CKO_01965 ghrA ghrA CKO_03054 CKO_03054 CKO_03049 CKO_03049 murB murB CKO_02747 CKO_02747 CKO_02736 CKO_02736
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
CKO_02560Hypothetical protein; KEGG: stm:STM0602 5.8e-159 ybdH; putative glycerol dehydrogenase K08317; COG: COG0371 Glycerol dehydrogenase and related enzymes. (362 aa)
tdhHypothetical protein; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (341 aa)
gpsAHypothetical protein; KEGG: ecs:ECs4486 6.9e-172 glycerol-3-phosphate dehydrogenase (NAD+) K00057; COG: COG0240 Glycerol-3-phosphate dehydrogenase; Psort location: Cytoplasmic, score:8.96; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (339 aa)
mtlDHypothetical protein; KEGG: sec:SC3610 2.8e-191 mtlD; mannitol-1-phosphate dehydrogenase K00009; COG: COG0246 Mannitol-1-phosphate/altronate dehydrogenases; Psort location: Cytoplasmic, score:8.96. (387 aa)
CKO_05045Hypothetical protein; KEGG: ecc:c4410 1.9e-183 yiaY; probable alcohol dehydrogenase K00001; COG: COG1454 Alcohol dehydrogenase, class IV; Psort location: Cytoplasmic, score:9.26. (422 aa)
dlgDHypothetical protein; Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate. (332 aa)
ghrBHypothetical protein; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily. (324 aa)
CKO_04923Hypothetical protein; KEGG: ecs:ECs4340 2.7e-113 3-oxoacyl-[acyl-carrier protein] reductase K00059; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: Cytoplasmic, score:9.97. (243 aa)
aroEHypothetical protein; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (272 aa)
mdhHypothetical protein; Catalyzes the reversible oxidation of malate to oxaloacetate. (312 aa)
garRHypothetical protein; Catalyzes the reduction of tatronate semialdehyde to D- glycerate; Belongs to the HIBADH-related family. 2-hydroxy-3- oxopropionate reductase subfamily. (296 aa)
CKO_04473Hypothetical protein; KEGG: plu:plu4115 6.9e-117 gldA; glycerol dehydrogenase (GLDH) K00005; COG: COG0371 Glycerol dehydrogenase and related enzymes; Psort location: Cytoplasmic, score:9.26. (368 aa)
CKO_04406Hypothetical protein; KEGG: sec:SC3108 2.6e-188 yqhD; putative alcohol dehydrogenase K08325; COG: COG1979 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family; Psort location: Cytoplasmic, score:9.26. (387 aa)
CKO_04377Hypothetical protein; KEGG: pfl:PFL_2420 1.3e-131 D-isomer specific 2-hydroxyacid dehydrogenase family protein K00002; COG: COG1064 Zn-dependent alcohol dehydrogenases; Psort location: Cytoplasmic, score:8.96. (351 aa)
CKO_04278Hypothetical protein; KEGG: eco:b2913 5.8e-207 serA; D-3-phosphoglycerate dehydrogenase K00058; COG: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Psort location: Cytoplasmic, score:9.97; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (410 aa)
CKO_04245Hypothetical protein; KEGG: eci:UTI89_C0329 1.6e-110 ykgE; hypothetical protein YkgE K00104; COG: COG0247 Fe-S oxidoreductase; Psort location: Cytoplasmic, score:8.96. (222 aa)
CKO_04157Hypothetical protein; KEGG: stm:STM2973 2.3e-187 fucO; L-1,2-propanediol oxidoreductase K00048; COG: COG1454 Alcohol dehydrogenase, class IV; Psort location: Cytoplasmic, score:9.26. (382 aa)
CKO_03733Hypothetical protein; KEGG: ecc:c1968 7.5e-214 ydfI; hypothetical oxidoreductase YdfI; COG: COG0246 Mannitol-1-phosphate/altronate dehydrogenases; Psort location: Cytoplasmic, score:8.96. (487 aa)
CKO_03717Hypothetical protein; KEGG: yps:YPTB1526 7.2e-193 sfcA, maeA; NAD-dependent malic enzyme K00027; COG: COG0281 Malic enzyme; Psort location: Cytoplasmic, score:8.96. (564 aa)
CKO_03534Hypothetical protein; KEGG: eci:UTI89_C4876 3.3e-172 yjgB; putative oxidoreductase K00100; COG: COG1064 Zn-dependent alcohol dehydrogenases. (339 aa)
CKO_03385Hypothetical protein; KEGG: sec:SC0002 0. thrA; aspartokinase I K00003:K00928; COG: COG0527 Aspartokinases; Psort location: Cytoplasmic, score:8.96; In the C-terminal section; belongs to the homoserine dehydrogenase family. (820 aa)
pdxAHypothetical protein; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (329 aa)
leuBHypothetical protein; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (363 aa)
dxrHypothetical protein; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP). (398 aa)
CKO_03131Hypothetical protein; Reduces 3-sulfolactaldehyde (SLA) to 2,3-dihydroxypropane 1- sulfonate (DHPS); Belongs to the HIBADH-related family. 3-sulfolactaldehyde reductase subfamily. (307 aa)
CKO_03104Hypothetical protein; KEGG: stm:STM4044 2.5e-190 putative alcohol dehydrogenase K00001; COG: COG1454 Alcohol dehydrogenase, class IV; Psort location: Cytoplasmic, score:9.26. (382 aa)
CKO_00028Hypothetical protein; KEGG: sdy:SDY_4168 2.9e-221 putative 6-phospho-beta-glucosidase K01222; COG: COG1486 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases; Psort location: Cytoplasmic, score:8.96. (440 aa)
ilvCHypothetical protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (491 aa)
wecCHypothetical protein; Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA); Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. WecC subfamily. (420 aa)
fadBHypothetical protein; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (729 aa)
guaBHypothetical protein; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (488 aa)
CKO_00332Hypothetical protein; KEGG: sty:STY2709 0. maeB; NADP-dependent malate dehydrogenase (decarboxylating) K00029; COG: COG0280 Phosphotransacetylase. (759 aa)
CKO_00342Hypothetical protein; KEGG: eci:UTI89_C2777 1.7e-182 eutG, yffV; ethanolamine utilization protein EutG iron-containing alcohol dehydrogenase K04022; COG: COG1454 Alcohol dehydrogenase, class IV; Psort location: Cytoplasmic, score:9.26. (395 aa)
fadJHypothetical protein; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (715 aa)
pdxBHypothetical protein; Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate. (378 aa)
CKO_00608Hypothetical protein; KEGG: ecc:c2709 3.7e-221 yeiQ; hypothetical oxidoreductase YeiQ; COG: COG0246 Mannitol-1-phosphate/altronate dehydrogenases; Psort location: Cytoplasmic, score:8.96. (488 aa)
CKO_00692Hypothetical protein; KEGG: ype:YPO2325 8.0e-162 dalD; D-arabinitol 4-dehydrogenase K00007; COG: COG0246 Mannitol-1-phosphate/altronate dehydrogenases. (455 aa)
fclHypothetical protein; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (321 aa)
CKO_00756Hypothetical protein; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (468 aa)
CKO_00757Hypothetical protein; KEGG: ecp:ECP_2071 2.4e-185 UDP-glucose 6-dehydrogenase K00012; COG: COG1004 Predicted UDP-glucose 6-dehydrogenase. (388 aa)
hisDHypothetical protein; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (434 aa)
CKO_00784Hypothetical protein; KEGG: spt:SPA0819 7.0e-163 pduQ; putative propanol dehydrogenase K00100; COG: COG1454 Alcohol dehydrogenase, class IV; Psort location: Cytoplasmic, score:9.97. (370 aa)
CKO_00862Hypothetical protein; KEGG: ecc:c2467 1.0e-152 bhbD; putative 3-hydroxyacyl-CoA dehydrogenase K00074; COG: COG1250 3-hydroxyacyl-CoA dehydrogenase. (289 aa)
zwfHypothetical protein; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (491 aa)
CKO_01178Hypothetical protein; KEGG: ece:Z2843 4.8e-180 yeaU; putative tartrate dehydrogenase K07246:K00056:K07247; COG: COG0473 Isocitrate/isopropylmalate dehydrogenase; Psort location: Cytoplasmic, score:9.26. (360 aa)
CKO_01318Hypothetical protein; KEGG: stm:STM1749 0. adhE; alcohol dehydrogenase / acetaldehyde dehydrogenase K00001:K04072; COG: COG1012 NAD-dependent aldehyde dehydrogenases; Psort location: Cytoplasmic, score:9.26; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (891 aa)
CKO_01429Hypothetical protein; KEGG: spt:SPA1239 2.2e-168 ldhA; D-lactate dehydrogenase K03778; COG: COG1052 Lactate dehydrogenase and related dehydrogenases; Psort location: Cytoplasmic, score:9.97; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (329 aa)
CKO_01455Hypothetical protein; KEGG: stm:STM1627 7.5e-198 alcohol dehydrogenase class III K00001:K00121; COG: COG1062 Zn-dependent alcohol dehydrogenases, class III; Psort location: Cytoplasmic, score:9.97; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (372 aa)
maeAHypothetical protein; KEGG: sfx:S1879 2.9e-292 sfcA; NAD-linked malate dehydrogenase (malic enzyme) K00027; COG: COG0281 Malic enzyme; Belongs to the malic enzymes family. (565 aa)
uxaBHypothetical protein; KEGG: eco:b1521 2.5e-231 uxaB, uxaB'; tagaturonate reductase K00041; COG: COG0246 Mannitol-1-phosphate/altronate dehydrogenases; Psort location: Cytoplasmic, score:8.96. (483 aa)
ldhHypothetical protein; Catalyzes the conversion of lactate to pyruvate. (338 aa)
CKO_01569Hypothetical protein; KEGG: eci:UTI89_C1762 2.1e-124 ydfG; probable oxidoreductase YdfG; COG: COG4221 Short-chain alcohol dehydrogenase of unknown specificity; Psort location: Cytoplasmic, score:9.26; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (264 aa)
CKO_01572Hypothetical protein; KEGG: ecc:c1968 1.7e-223 ydfI; hypothetical oxidoreductase YdfI; COG: COG0246 Mannitol-1-phosphate/altronate dehydrogenases. (490 aa)
CKO_01759Hypothetical protein; KEGG: sec:SC1337 2.7e-232 celF; phospho-beta-glucosidase (cellobiose-6-phosphate hydrolase) K01222; COG: COG1486 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases; Psort location: Cytoplasmic, score:8.96. (451 aa)
CKO_01835Hypothetical protein; KEGG: stm:STM1238 5.2e-222 icdA; isocitrate dehydrogenase K00031; COG: COG0538 Isocitrate dehydrogenases; Psort location: Cytoplasmic, score:9.97. (416 aa)
CKO_01965Hypothetical protein; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (244 aa)
ghrAHypothetical protein; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. (312 aa)
CKO_03054Hypothetical protein; KEGG: eco:b3940 0. metL, metM; aspartokinase II and homoserine dehydrogenase II K00003:K00928; COG: COG0527 Aspartokinases; Psort location: Cytoplasmic, score:8.96; In the C-terminal section; belongs to the homoserine dehydrogenase family. (810 aa)
CKO_03049Hypothetical protein; KEGG: stm:STM4108 2.8e-182 gldA; glycerol dehydrogenase K00005; COG: COG0371 Glycerol dehydrogenase and related enzymes; Psort location: Cytoplasmic, score:9.26. (367 aa)
murBHypothetical protein; Cell wall formation. (342 aa)
CKO_02747Hypothetical protein; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (367 aa)
CKO_02736Hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (303 aa)
Your Current Organism:
Citrobacter koseri
NCBI taxonomy Id: 290338
Other names: C. koseri ATCC BAA-895, Citrobacter (diversus) koseri ATCC BAA-895, Citrobacter koseri ATCC BAA-895, Citrobacter koseri str. ATCC BAA-895, Citrobacter koseri strain ATCC BAA-895
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