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metK metK CKO_04098 CKO_04098 ubiX ubiX CKO_03921 CKO_03921 ubiA ubiA miaA miaA speE speE uppS uppS menA menA thiE thiE ribH ribH cyoE cyoE selU selU CKO_02425 CKO_02425 nadA nadA CKO_02386 CKO_02386 aroA aroA CKO_01728 CKO_01728 CKO_01706 CKO_01706 CKO_01677 CKO_01677 CKO_01647 CKO_01647 CKO_01344 CKO_01344 kdsA kdsA cmoB cmoB CKO_00786 CKO_00786 CKO_00369 CKO_00369 CKO_00379 CKO_00379 hemC hemC CKO_00201 CKO_00201 CKO_00336 CKO_00336 CKO_00485 CKO_00485 murA murA CKO_04578 CKO_04578 CKO_04504 CKO_04504
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
metKHypothetical protein; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (384 aa)
CKO_04098Hypothetical protein; Involved in the non-oxidative decarboxylation and detoxification of phenolic derivatives. Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for phenolic acid decarboxylase. (197 aa)
ubiXHypothetical protein; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (189 aa)
CKO_03921Hypothetical protein; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (356 aa)
ubiAHypothetical protein; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. (289 aa)
miaAHypothetical protein; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (316 aa)
speEHypothetical protein; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. (288 aa)
uppSHypothetical protein; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. (229 aa)
menAHypothetical protein; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. (309 aa)
thiEHypothetical protein; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (211 aa)
ribHHypothetical protein; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. (156 aa)
cyoEHypothetical protein; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (296 aa)
selUHypothetical protein; Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2- selenouridine (Se2U-RNA). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain. (360 aa)
CKO_02425Hypothetical protein; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (200 aa)
nadAHypothetical protein; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate; Belongs to the quinolinate synthase A family. Type 1 subfamily. (348 aa)
CKO_02386Hypothetical protein; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (350 aa)
aroAHypothetical protein; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (427 aa)
CKO_01728Hypothetical protein; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (348 aa)
CKO_01706Hypothetical protein; KEGG: plu:plu0524 1.4e-164 unnamed protein product; similar to cystathionine beta-synthase K01697; COG: COG0031 Cysteine synthase. (456 aa)
CKO_01677Hypothetical protein; KEGG: ece:Z2688 7.6e-102 ribE; riboflavin synthase, alpha chain K00793; COG: COG0307 Riboflavin synthase alpha chain; Psort location: Cytoplasmic, score:8.96. (213 aa)
CKO_01647Hypothetical protein; KEGG: stm:STM1451 5.8e-88 gst; glutathionine S-transferase K00799; COG: COG0625 Glutathione S-transferase; Psort location: Cytoplasmic, score:9.97. (216 aa)
CKO_01344Hypothetical protein; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (196 aa)
kdsAHypothetical protein; KEGG: ecc:c1674 1.9e-144 kdsA; 2-dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase) K01627; COG: COG2877 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase; Psort location: Cytoplasmic, score:8.96; Belongs to the KdsA family. (284 aa)
cmoBHypothetical protein; Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L- methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5- carboxymethoxyuridine (cmo5U) at position 34 in tRNAs. (322 aa)
CKO_00786Hypothetical protein; KEGG: noc:Noc_0867 1.2e-27 cobalamin adenosyltransferase K00798; COG: COG2096 Uncharacterized conserved protein; Belongs to the Cob(I)alamin adenosyltransferase family. (336 aa)
CKO_00369Hypothetical protein; KEGG: sec:SC2439 1.8e-155 cysM; cysteine synthase B (O-acetylserine sulfhydrolase B) K01738; COG: COG0031 Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (322 aa)
CKO_00379Hypothetical protein; KEGG: sty:STY2666 1.0e-163 cysK; cysteine synthase A K01738; COG: COG0031 Cysteine synthase; Psort location: Cytoplasmic, score:8.96; Belongs to the cysteine synthase/cystathionine beta- synthase family. (323 aa)
hemCHypothetical protein; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (318 aa)
CKO_00201Hypothetical protein; COG: COG3148 Uncharacterized conserved protein. (174 aa)
CKO_00336Hypothetical protein; KEGG: stm:STM2467 2.8e-127 eutT; putative cobalamin adenosyltransferase, ethanolamine utilization K04032; COG: COG4812 Ethanolamine utilization cobalamin adenosyltransferase; Psort location: Cytoplasmic, score:8.96. (267 aa)
CKO_00485Hypothetical protein; KEGG: eci:UTI89_C2585 1.9e-89 yfcF; hypothetical protein K00799; COG: COG0625 Glutathione S-transferase; Psort location: Cytoplasmic, score:8.96. (239 aa)
murAHypothetical protein; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (419 aa)
CKO_04578Hypothetical protein; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (282 aa)
CKO_04504Hypothetical protein; KEGG: eci:UTI89_C3540 2.6e-172 yqjG; putative transferase K07393; COG: COG0435 Predicted glutathione S-transferase; Psort location: Cytoplasmic, score:8.96. (331 aa)
Your Current Organism:
Citrobacter koseri
NCBI taxonomy Id: 290338
Other names: C. koseri ATCC BAA-895, Citrobacter (diversus) koseri ATCC BAA-895, Citrobacter koseri ATCC BAA-895, Citrobacter koseri str. ATCC BAA-895, Citrobacter koseri strain ATCC BAA-895
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