STRINGSTRING
CKO_03339 CKO_03339 CKO_03256 CKO_03256 sthA sthA murB murB CKO_02965 CKO_02965 betA betA CKO_02552 CKO_02552 CKO_02505 CKO_02505 CKO_02501 CKO_02501 CKO_02436 CKO_02436 CKO_02209 CKO_02209 CKO_02207 CKO_02207 CKO_02047 CKO_02047 solA solA CKO_01778 CKO_01778 CKO_01722 CKO_01722 CKO_01404 CKO_01404 CKO_01293 CKO_01293 CKO_01196 CKO_01196 CKO_01163 CKO_01163 CKO_00928 CKO_00928 CKO_00864 CKO_00864 CKO_00754 CKO_00754 CKO_00719 CKO_00719 dld dld dusC dusC CKO_00654 CKO_00654 CKO_00536 CKO_00536 mnmC mnmC hmp hmp CKO_00107 CKO_00107 mnmG mnmG CKO_00013 CKO_00013 CKO_04956 CKO_04956 CKO_04789 CKO_04789 dusB dusB CKO_04272 CKO_04272 CKO_04271 CKO_04271 CKO_04128 CKO_04128 CKO_04125 CKO_04125 CKO_04121 CKO_04121 cysJ cysJ lhgD lhgD CKO_03993 CKO_03993 CKO_03935 CKO_03935 CKO_03926 CKO_03926 dusA dusA CKO_03852 CKO_03852 CKO_03678 CKO_03678 CKO_03612 CKO_03612 caiA caiA CKO_03340 CKO_03340 CKO_03301 CKO_03301
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CKO_03339Hypothetical protein; Part of an electron transfer system. Belongs to the ETF-QO/FixC family. (428 aa)
CKO_03256Hypothetical protein; KEGG: sec:SC0153 5.3e-252 lpdA; lipoamide dehydrogenase (NADH); component of 2-oxodehydrogenase and pyruvate complexes; L protein of glycine cleavage complex second part K00382; COG: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes; Psort location: Cytoplasmic, score:9.97. (475 aa)
sthAHypothetical protein; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (466 aa)
murBHypothetical protein; Cell wall formation. (342 aa)
CKO_02965Hypothetical protein; KEGG: eco:b0221 0. fadE, fadF, yafH; medium-long-chain fatty acyl-CoA dehydrogenase K06445; COG: COG1960 Acyl-CoA dehydrogenases; Psort location: CytoplasmicMembrane, score:9.93. (815 aa)
betAHypothetical protein; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. (558 aa)
CKO_02552Hypothetical protein; KEGG: eco:b0606 2.1e-266 ahpF; alkyl hydroperoxide reductase subunit, FAD/NAD(P)-binding, detoxification of hydroperoxides K03387; COG: COG3634 Alkyl hydroperoxide reductase, large subunit; Psort location: Cytoplasmic, score:9.97. (521 aa)
CKO_02505Hypothetical protein; KEGG: eci:UTI89_C0656 6.8e-149 ybeX; putative transport protein K06189; COG: COG4535 Putative Mg2+ and Co2+ transporter CorC; Psort location: Cytoplasmic, score:8.96. (315 aa)
CKO_02501Hypothetical protein; KEGG: ecj:JW0659 2.8e-191 ubiF; 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol oxygenase K03184; COG: COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. (391 aa)
CKO_02436Hypothetical protein; KEGG: ssn:SSO_0674 0. sdhA; succinate dehydrogenase, flavoprotein subunit K00239; COG: COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (588 aa)
CKO_02209Hypothetical protein; KEGG: ecc:c1004 4.9e-297 poxB; pyruvate dehydrogenase K00156; COG: COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Psort location: Cytoplasmic, score:8.96; Belongs to the TPP enzyme family. (572 aa)
CKO_02207Hypothetical protein; KEGG: stm:STM0936 4.4e-154 hcr; NADH oxidoreductase for hcp gene product; COG: COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1; Psort location: Cytoplasmic, score:8.96. (311 aa)
CKO_02047Hypothetical protein; KEGG: mav:MAV_3849 3.8e-29 wrbA; NAD(P)H:quinone oxidoreductase, type IV K00355; COG: COG0655 Multimeric flavodoxin WrbA. (198 aa)
solAHypothetical protein; Catalyzes the oxidative demethylation of N-methyl-L- tryptophan; Belongs to the MSOX/MTOX family. MTOX subfamily. (372 aa)
CKO_01778Hypothetical protein; KEGG: rfr:Rfer_1621 3.8e-52 pyridine nucleotide-disulphide oxidoreductase dimerisation protein K00520; COG: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes; Psort location: CytoplasmicMembrane, score:10.00. (224 aa)
CKO_01722Hypothetical protein; KEGG: eci:UTI89_C1879 0. ydiJ; hypothetical protein YdiJ; COG: COG0247 Fe-S oxidoreductase; Psort location: Cytoplasmic, score:8.96. (1018 aa)
CKO_01404Hypothetical protein; COG: NOG14120 non supervised orthologous group. (86 aa)
CKO_01293Hypothetical protein; KEGG: eca:ECA2991 0. nasB; nitrite reductase [NAD(P)H] large subunit K00362; COG: COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases; Psort location: Cytoplasmic, score:9.26; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (1355 aa)
CKO_01196Hypothetical protein; COG: COG3263 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain; Psort location: CytoplasmicMembrane, score:10.00. (535 aa)
CKO_01163Hypothetical protein; KEGG: eci:UTI89_C0656 7.4e-24 ybeX; putative transport protein K06189; COG: COG1253 Hemolysins and related proteins containing CBS domains; Psort location: CytoplasmicMembrane, score:10.00. (519 aa)
CKO_00928KEGG: bld:BLi00763 4.2e-69 hypothetical protein K00100; COG: COG0492 Thioredoxin reductase. (376 aa)
CKO_00864Hypothetical protein; KEGG: ecp:ECP_1975 1.9e-199 putative acyl-CoA dehydrogenase K00257; COG: COG1960 Acyl-CoA dehydrogenases; Psort location: Cytoplasmic, score:8.96. (376 aa)
CKO_00754Hypothetical protein; KEGG: pde:Pden_5043 3.9e-137 UDP-galactopyranose mutase K01854; COG: COG0562 UDP-galactopyranose mutase. (382 aa)
CKO_00719Hypothetical protein; KEGG: eci:UTI89_C0656 1.0e-24 ybeX; putative transport protein K06189; COG: COG1253 Hemolysins and related proteins containing CBS domains; Psort location: CytoplasmicMembrane, score:10.00. (527 aa)
dldHypothetical protein; Catalyzes the oxidation of D-lactate to pyruvate. Belongs to the quinone-dependent D-lactate dehydrogenase family. (600 aa)
dusCHypothetical protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs. Belongs to the Dus family. DusC subfamily. (312 aa)
CKO_00654Hypothetical protein; KEGG: stt:t0680 1.8e-210 putative n-hydroxybenzoate hydroxylase K00480; COG: COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases; Psort location: Cytoplasmic, score:8.96. (397 aa)
CKO_00536Hypothetical protein; KEGG: stm:STM2284 3.4e-282 glpA; sn-glycerol-3-phosphate dehydrogenase (anaerobic), large subunit K00111; COG: COG0578 Glycerol-3-phosphate dehydrogenase; Psort location: Cytoplasmic, score:9.97; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (542 aa)
mnmCHypothetical protein; Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34; In the N-terminal section; belongs to the methyltransferase superfamily. tRNA (mnm(5)s(2)U34)-methyltransferase family. (686 aa)
hmpHypothetical protein; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress; Belongs to the globin family. Two-domain flavohemoproteins subfamily. (396 aa)
CKO_00107Hypothetical protein; KEGG: stm:STM3901 2.1e-282 ilvG; acetolactate synthase large subunit K01652; COG: COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Psort location: Cytoplasmic, score:8.96. (548 aa)
mnmGHypothetical protein; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34; Belongs to the MnmG family. (629 aa)
CKO_00013Hypothetical protein; KEGG: ecc:c4596 1.6e-284 ilvB; acetolactate synthase isozyme I large subunit K01652; COG: COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. (564 aa)
CKO_04956Hypothetical protein; KEGG: ecs:ECs4372 9.0e-234 glutathione oxidoreductase K00383; COG: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes; Psort location: Cytoplasmic, score:9.97. (450 aa)
CKO_04789Hypothetical protein; KEGG: stm:STM3474 0. nirB; nitrite reductase, large subunit K00362; COG: COG1251 NAD(P)H-nitrite reductase; Psort location: Cytoplasmic, score:9.97; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (847 aa)
dusBHypothetical protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the Dus family. DusB subfamily. (321 aa)
CKO_04272Hypothetical protein; KEGG: sbo:SBO_3085 2.0e-181 ubiH; UbiH K03185; COG: COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. (392 aa)
CKO_04271Hypothetical protein; KEGG: ssn:SSO_3059 2.1e-193 visC; hypothetical protein; COG: COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases; Psort location: Cytoplasmic, score:8.96. (388 aa)
CKO_04128Hypothetical protein; KEGG: eci:UTI89_C3136 4.2e-252 hypothetical protein K00803; COG: COG0277 FAD/FMN-containing dehydrogenases; Psort location: Cytoplasmic, score:8.96. (484 aa)
CKO_04125Hypothetical protein; KEGG: fnu:FN1424 5.0e-08 acyl-CoA dehydrogenase, short-chain specific K00248; COG: COG2025 Electron transfer flavoprotein, alpha subunit; Psort location: Cytoplasmic, score:8.96. (284 aa)
CKO_04121Hypothetical protein; Part of an electron transfer system. Belongs to the ETF-QO/FixC family. (423 aa)
cysJHypothetical protein; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component; Belongs to the NADPH-dependent sulphite reductase flavoprotein subunit CysJ family. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (601 aa)
lhgDHypothetical protein; Catalyzes the dehydrogenation of L-2-hydroxyglutarate (L2HG) to alpha-ketoglutarate and couples to the respiratory chain by feeding electrons from the reaction into the membrane quinone pool. Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. Reaction=(S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol; Xref=Rhea:RHEA:58664, ChEBI:CHEBI:16782, ChEBI:CHEBI:16810, ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58665; Belongs to the L2HGDH family. (422 aa)
CKO_03993Hypothetical protein; KEGG: ypm:YP_1136 4.9e-297 ilvB1; putative thiamine pyrophosphate-dependent protein K03336; COG: COG3962 Acetolactate synthase; Belongs to the TPP enzyme family. (636 aa)
CKO_03935Hypothetical protein; KEGG: ece:Z3906m 6.9e-204 yfjD; uncharacterized CBS domain-containing protein K00638; COG: COG4536 Putative Mg2+ and Co2+ transporter CorB; Psort location: CytoplasmicMembrane, score:10.00. (413 aa)
CKO_03926Hypothetical protein; KEGG: btk:BT9727_4489 2.2e-19 cysJ; sulfite reductase [NADPH], flavoprotein, alpha subunit K00379; COG: COG3182 Uncharacterized iron-regulated membrane protein; Psort location: CytoplasmicMembrane, score:10.00. (452 aa)
dusAHypothetical protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs; Belongs to the Dus family. DusA subfamily. (345 aa)
CKO_03852Hypothetical protein; KEGG: eci:UTI89_C4633 9.6e-198 subunit of 2-oxoglutarate dehydrogenase K00382; COG: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes; Psort location: Cytoplasmic, score:9.97. (472 aa)
CKO_03678Hypothetical protein; KEGG: sec:SC4222 0. frdA; fumarate reductase, anaerobic, flavoprotein subunit K00244; COG: COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Psort location: Periplasmic, score:9.44. (608 aa)
CKO_03612Hypothetical protein; KEGG: hpa:HPAG1_1423 1.9e-41 putative integral membrane protein with a TlyC-like hemolysin domain K00088; COG: COG1253 Hemolysins and related proteins containing CBS domains; Psort location: CytoplasmicMembrane, score:10.00. (447 aa)
caiAHypothetical protein; Catalyzes the reduction of crotonobetainyl-CoA to gamma- butyrobetainyl-CoA; Belongs to the acyl-CoA dehydrogenase family. (380 aa)
CKO_03340Hypothetical protein; KEGG: fnu:FN1424 3.4e-26 acyl-CoA dehydrogenase, short-chain specific K00248; COG: COG2025 Electron transfer flavoprotein, alpha subunit. (293 aa)
CKO_03301Hypothetical protein; KEGG: ssn:SSO_0084 8.0e-297 ilvI; acetolactate synthase isozyme III large subunit K01652; COG: COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. (574 aa)
Your Current Organism:
Citrobacter koseri
NCBI taxonomy Id: 290338
Other names: C. koseri ATCC BAA-895, Citrobacter (diversus) koseri ATCC BAA-895, Citrobacter koseri ATCC BAA-895, Citrobacter koseri str. ATCC BAA-895, Citrobacter koseri strain ATCC BAA-895
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.