STRINGSTRING
selA selA wecE wecE glyA glyA iscS iscS CKO_00371 CKO_00371 CKO_00421 CKO_00421 CKO_00505 CKO_00505 hisC hisC CKO_01017 CKO_01017 CKO_01022 CKO_01022 CKO_01477 CKO_01477 CKO_01629 CKO_01629 CKO_01707 CKO_01707 sufS sufS astC astC CKO_02139 CKO_02139 serC serC CKO_02211 CKO_02211 bioF bioF bioA bioA CKO_02469 CKO_02469 CKO_02518 CKO_02518 CKO_02559 CKO_02559 CKO_02700 CKO_02700 tnaA tnaA CKO_03055 CKO_03055 CKO_03180 CKO_03180 hemL hemL CKO_03450 CKO_03450 CKO_03454 CKO_03454 tpl tpl CKO_03585 CKO_03585 CKO_03855 CKO_03855 CKO_04009 CKO_04009 CKO_04020 CKO_04020 CKO_04174 CKO_04174 gcvP gcvP CKO_04340 CKO_04340 CKO_04402 CKO_04402 patA patA CKO_04539 CKO_04539 argD argD CKO_04796 CKO_04796 CKO_04884 CKO_04884 CKO_04984 CKO_04984 CKO_05030 CKO_05030 kbl kbl CKO_05128 CKO_05128
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
selAHypothetical protein; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis; Belongs to the SelA family. (481 aa)
wecEHypothetical protein; Catalyzes the synthesis of dTDP-4-amino-4,6-dideoxy-D- galactose (dTDP-Fuc4N) from dTDP-4-keto-6-deoxy-D-glucose (dTDP-D- Glc4O) and L-glutamate; Belongs to the DegT/DnrJ/EryC1 family. (376 aa)
glyAHypothetical protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (419 aa)
iscSHypothetical protein; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. (411 aa)
CKO_00371Hypothetical protein; KEGG: nwi:Nwi_0881 1.1e-26 transcriptional regulatory protein GntR family K00825; COG: COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs. (430 aa)
CKO_00421Hypothetical protein; KEGG: eco:b2379 2.5e-215 yfdZ; putative PLP-dependent aminotransferase; COG: COG0436 Aspartate/tyrosine/aromatic aminotransferase; Psort location: Cytoplasmic, score:8.96. (412 aa)
CKO_00505Hypothetical protein; KEGG: sdy:SDY_2486 1.9e-217 putative aminotransferase K00812; COG: COG0436 Aspartate/tyrosine/aromatic aminotransferase; Psort location: Cytoplasmic, score:8.96. (405 aa)
hisCHypothetical protein; KEGG: ece:Z3183 4.1e-174 hisC; histidinol-phosphate aminotransferase K00817; COG: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; Psort location: Cytoplasmic, score:8.96; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (359 aa)
CKO_01017Hypothetical protein; COG: NOG17471 non supervised orthologous group; Psort location: Cytoplasmic, score:8.96. (277 aa)
CKO_01022Hypothetical protein; KEGG: psp:PSPPH_3420 6.3e-130 aminotransferase, DegT/DnrJ/EryC1/StrS family K01726; COG: COG0399 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis; Belongs to the DegT/DnrJ/EryC1 family. (405 aa)
CKO_01477Hypothetical protein; KEGG: eci:UTI89_C1658 5.5e-218 ydcR; hypothetical protein YdcR K00811; COG: COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs; Psort location: Cytoplasmic, score:9.26. (469 aa)
CKO_01629Hypothetical protein; KEGG: ece:Z2627 6.4e-185 malY; enzyme that may degrade or block biosynthesis of endogenous mal inducer, probably aminotrasferase K01760; COG: COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities. (390 aa)
CKO_01707Hypothetical protein; KEGG: plu:plu0523 1.2e-149 unnamed protein product; similar to cystathionine gamma-lyase K01758; COG: COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases; Psort location: Cytoplasmic, score:9.97. (381 aa)
sufSHypothetical protein; Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L- selenocysteine. Selenocysteine lyase activity is however unsure in vivo. (406 aa)
astCHypothetical protein; Catalyzes the transamination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate. Can also act as an acetylornithine aminotransferase. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. AstC subfamily. (406 aa)
CKO_02139Hypothetical protein; KEGG: ecj:JW0911 2.0e-204 aspC; aspartate aminotransferase, PLP-dependent K00813; COG: COG1448 Aspartate/tyrosine/aromatic aminotransferase; Psort location: Cytoplasmic, score:9.26. (396 aa)
serCHypothetical protein; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (362 aa)
CKO_02211Hypothetical protein; KEGG: ecj:JW0854 5.8e-159 ltaE; L-allo-threonine aldolase, PLP-dependent K01620; COG: COG2008 Threonine aldolase. (318 aa)
bioFHypothetical protein; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (384 aa)
bioAHypothetical protein; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (429 aa)
CKO_02469Hypothetical protein; KEGG: ssn:SSO_0644 0. speF; ornithine decarboxylase isozyme, inducible K01581; COG: COG1982 Arginine/lysine/ornithine decarboxylases. (758 aa)
CKO_02518Hypothetical protein; KEGG: stt:t2223 1.6e-149 cobD; threonine-phosphate decarboxylase K04720; COG: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; Psort location: Cytoplasmic, score:8.96. (364 aa)
CKO_02559Hypothetical protein; KEGG: sec:SC0634 8.8e-188 ybdL; putative aminotransferase K00812; COG: COG0436 Aspartate/tyrosine/aromatic aminotransferase. (389 aa)
CKO_02700Hypothetical protein; KEGG: rha:RHA1_ro05556 2.4e-98 transcriptional regulator/aminotransferase; COG: COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs. (475 aa)
tnaAHypothetical protein; KEGG: plu:plu0799 4.2e-220 tnaA; tryptophanase (L-tryptophan indole-lyase) (TNase) K01667; COG: COG3033 Tryptophanase; Psort location: Cytoplasmic, score:8.96; Belongs to the beta-eliminating lyase family. (462 aa)
CKO_03055Hypothetical protein; KEGG: eco:b3939 2.8e-198 metB, met-1, met1; cystathionine gamma-synthase K01739; COG: COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases; Psort location: Cytoplasmic, score:9.97. (386 aa)
CKO_03180Hypothetical protein; KEGG: eco:b0186 0. ldcC; lysine decarboxylase 2, constitutive K01582; COG: COG1982 Arginine/lysine/ornithine decarboxylases. (712 aa)
hemLHypothetical protein; KEGG: sbo:SBO_0143 1.2e-183 hemL; glutamate-1-semialdehyde aminotransferase K01845; COG: COG0001 Glutamate-1-semialdehyde aminotransferase; Psort location: Cytoplasmic, score:8.96. (352 aa)
CKO_03450Hypothetical protein; KEGG: bur:Bcep18194_B1266 1.4e-79 transcriptional regulator, GntR family with aminotransferase activity K00825; COG: COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs; Psort location: Cytoplasmic, score:9.26. (470 aa)
CKO_03454Hypothetical protein; KEGG: sfl:SF3053 3.6e-159 metC; cystathionine beta-lyase K01760; COG: COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases; Psort location: Cytoplasmic, score:9.26. (396 aa)
tplHypothetical protein; KEGG: tde:TDE1118 2.4e-208 tpl; tyrosine phenol-lyase K01668; COG: COG3033 Tryptophanase. (465 aa)
CKO_03585Hypothetical protein; KEGG: efa:EF0838 4.3e-92 pyridoxal phosphate-dependent enzyme, putative K01042; COG: COG1921 Selenocysteine synthase [seryl-tRNASer selenium transferase]. (353 aa)
CKO_03855Hypothetical protein; KEGG: eco:b4054 8.6e-197 tyrB; tyrosine aminotransferase, tyrosine repressible K00832; COG: COG1448 Aspartate/tyrosine/aromatic aminotransferase; Psort location: Cytoplasmic, score:9.97. (397 aa)
CKO_04009Hypothetical protein; KEGG: ecj:JW2637 1.5e-208 gabT; 4-aminobutyrate aminotransferase, PLP-dependent K00823:K07250; COG: COG0160 4-aminobutyrate aminotransferase and related aminotransferases; Psort location: Cytoplasmic, score:8.96; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (427 aa)
CKO_04020Hypothetical protein; KEGG: eci:UTI89_C3030 1.7e-184 hypothetical protein K00375; COG: COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs; Psort location: Cytoplasmic, score:9.26. (450 aa)
CKO_04174Hypothetical protein; KEGG: ssn:SSO_2967 3.1e-192 cysteine sulfinate desulfinase; COG: COG0520 Selenocysteine lyase; Psort location: Cytoplasmic, score:8.96. (401 aa)
gcvPHypothetical protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (957 aa)
CKO_04340Hypothetical protein; KEGG: stm:STM3114 0. speC; ornithine decarboxylase isozyme K01581; COG: COG1982 Arginine/lysine/ornithine decarboxylases. (711 aa)
CKO_04402Hypothetical protein; KEGG: ecc:c3742 8.1e-201 metC; cystathionine beta-lyase K01760; COG: COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases; Psort location: Cytoplasmic, score:9.26. (421 aa)
patAHypothetical protein; Catalyzes the aminotransferase reaction from putrescine to 2- oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. This is the first step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate (gamma-aminobutyrate or GABA) via 4- aminobutanal. Also functions as a cadaverine transaminase in a a L- lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. (503 aa)
CKO_04539Hypothetical protein; KEGG: ecc:c1175 1.0e-184 putative aminotransferase K00842; COG: COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities; Psort location: Cytoplasmic, score:8.96. (390 aa)
argDHypothetical protein; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (405 aa)
CKO_04796Hypothetical protein; KEGG: tfu:Tfu_0632 7.7e-08 cystathionine gamma-synthase K01739; COG: NOG06470 non supervised orthologous group. (360 aa)
CKO_04884Hypothetical protein; KEGG: eca:ECA2053 6.6e-167 gabT, goaG; 4-aminobutyrate aminotransferase K00823:K07250; COG: COG0160 4-aminobutyrate aminotransferase and related aminotransferases; Psort location: Cytoplasmic, score:8.96; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (421 aa)
CKO_04984Hypothetical protein; KEGG: tde:TDE2200 6.7e-126 megL; methionine gamma-lyase K01761; COG: COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases; Psort location: Cytoplasmic, score:9.97. (398 aa)
CKO_05030Hypothetical protein; KEGG: eci:UTI89_C4114 1.3e-216 avtA; valine--pyruvate aminotransferase K00835; COG: COG3977 Alanine-alpha-ketoisovalerate (or valine-pyruvate) aminotransferase; Psort location: Cytoplasmic, score:8.96. (430 aa)
kblHypothetical protein; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (398 aa)
CKO_05128Hypothetical protein; KEGG: stm:STM3768 1.6e-170 putative selenocysteine synthase [L-seryl-tRNA(Ser) selenium transferase K01042; COG: COG1921 Selenocysteine synthase [seryl-tRNASer selenium transferase]; Psort location: Cytoplasmic, score:8.96. (369 aa)
Your Current Organism:
Citrobacter koseri
NCBI taxonomy Id: 290338
Other names: C. koseri ATCC BAA-895, Citrobacter (diversus) koseri ATCC BAA-895, Citrobacter koseri ATCC BAA-895, Citrobacter koseri str. ATCC BAA-895, Citrobacter koseri strain ATCC BAA-895
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.