STRINGSTRING
glyA glyA CKO_00497 CKO_00497 ackA ackA CKO_00636 CKO_00636 CKO_00687 CKO_00687 CKO_01455 CKO_01455 eno eno CKO_01725 CKO_01725 CKO_01748 CKO_01748 CKO_01828 CKO_01828 CKO_01829 CKO_01829 serC serC gpmA gpmA ppc ppc CKO_03075 CKO_03075 pfkA pfkA CKO_03116 CKO_03116 CKO_03117 CKO_03117 CKO_03118 CKO_03118 CKO_03119 CKO_03119 gpmB gpmB CKO_03400 CKO_03400 fbp fbp CKO_03797 CKO_03797 acs acs eno-2 eno-2 CKO_04278 CKO_04278 CKO_04295 CKO_04295 CKO_04305 CKO_04305 CKO_04479 CKO_04479 mdh mdh gpmI gpmI
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
glyAHypothetical protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (419 aa)
CKO_00497Hypothetical protein; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (709 aa)
ackAHypothetical protein; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa)
CKO_00636Hypothetical protein; Serine hydrolase involved in the detoxification of formaldehyde. (278 aa)
CKO_00687Hypothetical protein; KEGG: eco:b2097 1.6e-181 fbaB, dhnA; fructose-bisphosphate aldolase class I K01623; COG: COG1830 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes. (350 aa)
CKO_01455Hypothetical protein; KEGG: stm:STM1627 7.5e-198 alcohol dehydrogenase class III K00001:K00121; COG: COG1062 Zn-dependent alcohol dehydrogenases, class III; Psort location: Cytoplasmic, score:9.97; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (372 aa)
enoHypothetical protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (428 aa)
CKO_01725Hypothetical protein; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (792 aa)
CKO_01748Hypothetical protein; KEGG: stm:STM1326 2.9e-148 pfkB; 6-phosphofructokinase II K00850; COG: COG1105 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB); Psort location: Cytoplasmic, score:9.26; Belongs to the carbohydrate kinase PfkB family. (309 aa)
CKO_01828Hypothetical protein; KEGG: eci:UTI89_C2076 0. bisZ; trimethylamine-N-oxide reductase 2 precursor K07812; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: Periplasmic, score:10.00. (821 aa)
CKO_01829Hypothetical protein; KEGG: eci:UTI89_C2480 7.4e-33 napC; cytochrome c protein, subunit of nitrate reductase, periplasmic K02569; COG: COG3005 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit; Psort location: CytoplasmicMembrane, score:8.02. (320 aa)
serCHypothetical protein; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (362 aa)
gpmAHypothetical protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (250 aa)
ppcHypothetical protein; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (883 aa)
CKO_03075Hypothetical protein; KEGG: ecj:JW3896 1.5e-167 glpX; fructose 1,6-bisphosphatase II K02446; COG: COG1494 Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins; Psort location: Cytoplasmic, score:8.96. (336 aa)
pfkAHypothetical protein; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (320 aa)
CKO_03116Hypothetical protein; KEGG: ecs:ECs4820 6.0e-102 formate dehydrogenase-O major subunit K00123; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: Periplasmic, score:9.76. (195 aa)
CKO_03117Hypothetical protein; KEGG: sty:STY3839 0. fdoG; formate dehydrogenase-O, major subunit K00123; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: Periplasmic, score:9.44; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (804 aa)
CKO_03118Hypothetical protein; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. (300 aa)
CKO_03119Hypothetical protein; KEGG: sec:SC3925 4.6e-111 fdoI; formate dehydrogenase, cytochrome b556 (FDO) subunit K00127; COG: COG2864 Cytochrome b subunit of formate dehydrogenase; Psort location: CytoplasmicMembrane, score:10.00. (211 aa)
gpmBHypothetical protein; KEGG: stm:STM4585 5.6e-106 gpmB; putative phosphoglyceromutase 2 K01834; COG: COG0406 Fructose-2,6-bisphosphatase; Psort location: Cytoplasmic, score:8.96; Belongs to the phosphoglycerate mutase family. GpmB subfamily. (215 aa)
CKO_03400Hypothetical protein; KEGG: ecc:c5473 2.5e-167 serB; phosphoserine phosphatase K01079; COG: COG0560 Phosphoserine phosphatase. (334 aa)
fbpHypothetical protein; KEGG: ecc:c5329 5.9e-182 fbp; fructose-1,6-bisphosphatase K03841; COG: COG0158 Fructose-1,6-bisphosphatase; Psort location: Cytoplasmic, score:8.96. (393 aa)
CKO_03797Hypothetical protein; KEGG: ecs:ECs5069 3.9e-137 putative fructose-bisphosphate aldolase K01624; COG: COG0191 Fructose/tagatose bisphosphate aldolase; Psort location: Cytoplasmic, score:8.96. (286 aa)
acsHypothetical protein; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (652 aa)
eno-2Hypothetical protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (432 aa)
CKO_04278Hypothetical protein; KEGG: eco:b2913 5.8e-207 serA; D-3-phosphoglycerate dehydrogenase K00058; COG: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Psort location: Cytoplasmic, score:9.97; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (410 aa)
CKO_04295Hypothetical protein; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (359 aa)
CKO_04305KEGG: ypn:YPN_3759 7.8e-93 hypothetical protein K02446; COG: COG1494 Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins. (323 aa)
CKO_04479Hypothetical protein; KEGG: rle:RL2900 2.7e-129 dhaK; putative dihydroxyacetone kinase K00863; COG: COG2376 Dihydroxyacetone kinase. (552 aa)
mdhHypothetical protein; Catalyzes the reversible oxidation of malate to oxaloacetate. (312 aa)
gpmIHypothetical protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (507 aa)
Your Current Organism:
Citrobacter koseri
NCBI taxonomy Id: 290338
Other names: C. koseri ATCC BAA-895, Citrobacter (diversus) koseri ATCC BAA-895, Citrobacter koseri ATCC BAA-895, Citrobacter koseri str. ATCC BAA-895, Citrobacter koseri strain ATCC BAA-895
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