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CKO_00011 CKO_00011 CKO_00013 CKO_00013 asnA asnA CKO_00107 CKO_00107 CKO_00108 CKO_00108 ilvE ilvE ilvD ilvD ilvA ilvA ilvC ilvC dapF dapF metE metE glyA glyA dapA dapA dapE dapE CKO_00329 CKO_00329 tal tal CKO_00369 CKO_00369 CKO_00379 CKO_00379 CKO_00435 CKO_00435 aroC aroC CKO_00492 CKO_00492 CKO_00493 CKO_00493 CKO_00505 CKO_00505 CKO_00633 CKO_00633 CKO_00687 CKO_00687 hisI hisI hisF hisF hisA hisA hisH hisH hisB hisB hisC hisC hisD hisD hisG hisG CKO_00923 CKO_00923 CKO_01110 CKO_01110 CKO_01166 CKO_01166 prs prs trpA trpA trpB trpB trpC trpC trpD trpD CKO_01340 CKO_01340 CKO_01358 CKO_01358 CKO_01450 CKO_01450 eno eno CKO_01563 CKO_01563 CKO_01629 CKO_01629 CKO_01706 CKO_01706 CKO_01707 CKO_01707 CKO_01709 CKO_01709 CKO_01728 CKO_01728 CKO_01748 CKO_01748 CKO_01800 CKO_01800 CKO_01835 CKO_01835 CKO_02139 CKO_02139 aroA aroA serC serC CKO_02211 CKO_02211 CKO_02363 CKO_02363 gpmA gpmA CKO_02386 CKO_02386 CKO_02439 CKO_02439 CKO_02490 CKO_02490 CKO_02713 CKO_02713 aroK aroK proC proC CKO_02941 CKO_02941 proA proA proB proB argH argH argB argB argC argC argE argE CKO_03054 CKO_03054 CKO_03055 CKO_03055 tpiA tpiA pfkA pfkA CKO_03140 CKO_03140 dapD dapD mtnN mtnN CKO_03252 CKO_03252 CKO_03300 CKO_03300 CKO_03301 CKO_03301 leuA leuA leuB leuB leuC leuC leuD leuD dapB dapB tal-2 tal-2 CKO_03383 CKO_03383 thrB thrB CKO_03385 CKO_03385 gpmB gpmB CKO_03400 CKO_03400 CKO_03454 CKO_03454 argI argI argI-2 argI-2 CKO_03782 CKO_03782 CKO_03797 CKO_03797 CKO_03855 CKO_03855 CKO_03894 CKO_03894 CKO_03902 CKO_03902 metAS metAS CKO_03919 CKO_03919 CKO_03920 CKO_03920 CKO_03921 CKO_03921 luxS luxS eno-2 eno-2 CKO_04154 CKO_04154 argA argA lysA lysA CKO_04278 CKO_04278 rpiA rpiA CKO_04295 CKO_04295 pgk pgk CKO_04309 CKO_04309 metK metK CKO_04402 CKO_04402 CKO_04512 CKO_04512 CKO_04517 CKO_04517 CKO_04539 CKO_04539 argG argG CKO_04620 CKO_04620 CKO_04622 CKO_04622 aroQ aroQ aroE aroE argD argD CKO_04807 CKO_04807 aroB aroB aroK-2 aroK-2 asd asd CKO_05064 CKO_05064 gpmI gpmI
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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CKO_00011Hypothetical protein; KEGG: sty:STY3987 7.8e-45 ilvN; acetolactate synthase small subunit K01653; COG: COG0440 Acetolactate synthase, small (regulatory) subunit; Psort location: Cytoplasmic, score:8.96. (96 aa)
CKO_00013Hypothetical protein; KEGG: ecc:c4596 1.6e-284 ilvB; acetolactate synthase isozyme I large subunit K01652; COG: COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. (564 aa)
asnAHypothetical protein; KEGG: eci:UTI89_C4299 2.4e-169 asnA; asparagine synthetase A K01914; COG: COG2502 Asparagine synthetase A; Psort location: Cytoplasmic, score:10.00. (350 aa)
CKO_00107Hypothetical protein; KEGG: stm:STM3901 2.1e-282 ilvG; acetolactate synthase large subunit K01652; COG: COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Psort location: Cytoplasmic, score:8.96. (548 aa)
CKO_00108Hypothetical protein; KEGG: sec:SC3807 4.1e-39 ilvM; acetolactate synthase II, small subunit K01653; COG: COG3978 Acetolactate synthase (isozyme II), small (regulatory) subunit; Psort location: Cytoplasmic, score:8.96. (87 aa)
ilvEHypothetical protein; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (309 aa)
ilvDHypothetical protein; KEGG: eci:UTI89_C4327 0. ilvD; dihydroxy-acid dehydratase K01687; COG: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (602 aa)
ilvAHypothetical protein; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (515 aa)
ilvCHypothetical protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (491 aa)
dapFHypothetical protein; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (275 aa)
metEHypothetical protein; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (753 aa)
glyAHypothetical protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (419 aa)
dapAHypothetical protein; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa)
dapEHypothetical protein; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (375 aa)
CKO_00329Hypothetical protein; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (664 aa)
talHypothetical protein; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (316 aa)
CKO_00369Hypothetical protein; KEGG: sec:SC2439 1.8e-155 cysM; cysteine synthase B (O-acetylserine sulfhydrolase B) K01738; COG: COG0031 Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (322 aa)
CKO_00379Hypothetical protein; KEGG: sty:STY2666 1.0e-163 cysK; cysteine synthase A K01738; COG: COG0031 Cysteine synthase; Psort location: Cytoplasmic, score:8.96; Belongs to the cysteine synthase/cystathionine beta- synthase family. (323 aa)
CKO_00435Hypothetical protein; KEGG: eci:UTI89_C1638 1.5e-137 glyceraldehyde 3-phosphate dehydrogenase A K00134; COG: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Psort location: Cytoplasmic, score:9.97. (333 aa)
aroCHypothetical protein; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (361 aa)
CKO_00492Hypothetical protein; KEGG: sec:SC2342 5.8e-136 tktN; putative transketolase K00615; COG: COG3959 Transketolase, N-terminal subunit; Psort location: Cytoplasmic, score:8.96. (276 aa)
CKO_00493Hypothetical protein; KEGG: stm:STM2340 7.1e-154 putative transketolase K00615; COG: COG3958 Transketolase, C-terminal subunit; Psort location: Cytoplasmic, score:8.96. (317 aa)
CKO_00505Hypothetical protein; KEGG: sdy:SDY_2486 1.9e-217 putative aminotransferase K00812; COG: COG0436 Aspartate/tyrosine/aromatic aminotransferase; Psort location: Cytoplasmic, score:8.96. (405 aa)
CKO_00633Hypothetical protein; KEGG: stm:STM2196 1.0e-184 L-serine dehydratase K01752; COG: COG1760 L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (433 aa)
CKO_00687Hypothetical protein; KEGG: eco:b2097 1.6e-181 fbaB, dhnA; fructose-bisphosphate aldolase class I K01623; COG: COG1830 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes. (350 aa)
hisIHypothetical protein; KEGG: ssn:SSO_2097 6.9e-101 hisI; phosphoribosyl-amp cyclohydrolase; phosphoribosyl-ATP pyrophosphatase K01496:K01523; COG: COG0139 Phosphoribosyl-AMP cyclohydrolase; Psort location: Cytoplasmic, score:9.97; In the N-terminal section; belongs to the PRA-CH family. (203 aa)
hisFHypothetical protein; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (258 aa)
hisAHypothetical protein; KEGG: spt:SPA0795 5.8e-120 hisA; phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase K01814; COG: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; Psort location: Cytoplasmic, score:9.97. (245 aa)
hisHHypothetical protein; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (196 aa)
hisBHypothetical protein; KEGG: stm:STM2074 1.7e-184 hisB; histidinol-phosphatase / imidazoleglycerol-phosphate dehydratase K01089:K01693; COG: COG0131 Imidazoleglycerol-phosphate dehydratase; Psort location: Cytoplasmic, score:8.96; In the N-terminal section; belongs to the histidinol- phosphatase family. (355 aa)
hisCHypothetical protein; KEGG: ece:Z3183 4.1e-174 hisC; histidinol-phosphate aminotransferase K00817; COG: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; Psort location: Cytoplasmic, score:8.96; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (359 aa)
hisDHypothetical protein; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (434 aa)
hisGHypothetical protein; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. (329 aa)
CKO_00923Hypothetical protein; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. (79 aa)
CKO_01110Hypothetical protein; KEGG: spt:SPA0981 2.6e-243 pykA; pyruvate kinase A K00873; COG: COG0469 Pyruvate kinase; Psort location: Cytoplasmic, score:8.96. (480 aa)
CKO_01166Hypothetical protein; KEGG: stm:STM1826 2.7e-234 sdaA; L-serine deaminase I/L-threonine deaminase I K01752; COG: COG1760 L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (473 aa)
prsHypothetical protein; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (321 aa)
trpAHypothetical protein; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (268 aa)
trpBHypothetical protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (397 aa)
trpCHypothetical protein; KEGG: sfx:S1351 2.8e-214 trpC; N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase K01609:K01817; COG: COG0134 Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (453 aa)
trpDHypothetical protein; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (531 aa)
CKO_01340Hypothetical protein; KEGG: stm:STM1723 1.2e-252 trpE; anthranilate synthase, component I K01657; COG: COG0147 Anthranilate/para-aminobenzoate synthases component I; Psort location: Cytoplasmic, score:8.96. (524 aa)
CKO_01358Hypothetical protein; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (891 aa)
CKO_01450Hypothetical protein; KEGG: ssn:SSO_1725 1.5e-160 gapC; glyceraldehyde-3-phosphate dehydrogenase K00134; COG: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Psort location: Cytoplasmic, score:9.97. (333 aa)
enoHypothetical protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (428 aa)
CKO_01563Hypothetical protein; KEGG: lsl:LSL_0129 4.2e-78 metE; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase K00549; COG: COG0620 Methionine synthase II (cobalamin-independent); Psort location: Cytoplasmic, score:8.96. (367 aa)
CKO_01629Hypothetical protein; KEGG: ece:Z2627 6.4e-185 malY; enzyme that may degrade or block biosynthesis of endogenous mal inducer, probably aminotrasferase K01760; COG: COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities. (390 aa)
CKO_01706Hypothetical protein; KEGG: plu:plu0524 1.4e-164 unnamed protein product; similar to cystathionine beta-synthase K01697; COG: COG0031 Cysteine synthase. (456 aa)
CKO_01707Hypothetical protein; KEGG: plu:plu0523 1.2e-149 unnamed protein product; similar to cystathionine gamma-lyase K01758; COG: COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases; Psort location: Cytoplasmic, score:9.97. (381 aa)
CKO_01709Hypothetical protein; KEGG: stm:STM1378 2.2e-237 pykF; pyruvate kinase I (formerly F), fructose stimulated K00873; COG: COG0469 Pyruvate kinase. (470 aa)
CKO_01728Hypothetical protein; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (348 aa)
CKO_01748Hypothetical protein; KEGG: stm:STM1326 2.9e-148 pfkB; 6-phosphofructokinase II K00850; COG: COG1105 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB); Psort location: Cytoplasmic, score:9.26; Belongs to the carbohydrate kinase PfkB family. (309 aa)
CKO_01800Hypothetical protein; KEGG: stt:t1169 8.8e-172 gapA; glyceraldehyde 3-phosphate dehydrogenase A K00134; COG: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Psort location: Cytoplasmic, score:9.97. (331 aa)
CKO_01835Hypothetical protein; KEGG: stm:STM1238 5.2e-222 icdA; isocitrate dehydrogenase K00031; COG: COG0538 Isocitrate dehydrogenases; Psort location: Cytoplasmic, score:9.97. (416 aa)
CKO_02139Hypothetical protein; KEGG: ecj:JW0911 2.0e-204 aspC; aspartate aminotransferase, PLP-dependent K00813; COG: COG1448 Aspartate/tyrosine/aromatic aminotransferase; Psort location: Cytoplasmic, score:9.26. (396 aa)
aroAHypothetical protein; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (427 aa)
serCHypothetical protein; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (362 aa)
CKO_02211Hypothetical protein; KEGG: ecj:JW0854 5.8e-159 ltaE; L-allo-threonine aldolase, PLP-dependent K01620; COG: COG2008 Threonine aldolase. (318 aa)
CKO_02363Hypothetical protein; KEGG: ecp:ECP_0784 0. aconitate hydratase K01680; COG: COG1048 Aconitase A; Psort location: Cytoplasmic, score:9.26. (752 aa)
gpmAHypothetical protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (250 aa)
CKO_02386Hypothetical protein; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (350 aa)
CKO_02439Hypothetical protein; KEGG: sec:SC0736 1.7e-225 gltA; citrate synthase K01647; COG: COG0372 Citrate synthase; Psort location: Cytoplasmic, score:9.26. (427 aa)
CKO_02490Hypothetical protein; KEGG: stm:STM0680 1.3e-294 asnB; asparagine synthetase B K01953; COG: COG0367 Asparagine synthase (glutamine-hydrolyzing); Psort location: Cytoplasmic, score:8.96. (558 aa)
CKO_02713Hypothetical protein; KEGG: sec:SC0500 8.5e-174 putative cysteine synthase/cystathionine beta-synthase K01738; COG: COG0031 Cysteine synthase; Psort location: Cytoplasmic, score:8.96. (351 aa)
aroKHypothetical protein; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (162 aa)
proCHypothetical protein; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (269 aa)
CKO_02941Hypothetical protein; KEGG: eca:ECA3126 2.3e-171 metE; 5-methyltetrahydropteroyltriglutamate- homocystein e methyltransferase K00549; COG: COG0620 Methionine synthase II (cobalamin-independent); Psort location: Cytoplasmic, score:8.96. (343 aa)
proAHypothetical protein; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (417 aa)
proBHypothetical protein; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (367 aa)
argHHypothetical protein; KEGG: ssn:SSO_4133 2.5e-231 argH; argininosuccinate lyase K01755; COG: COG0165 Argininosuccinate lyase; Psort location: Cytoplasmic, score:8.96. (457 aa)
argBHypothetical protein; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate. (258 aa)
argCHypothetical protein; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (334 aa)
argEHypothetical protein; KEGG: eci:UTI89_C4548 4.0e-208 argE; acetylornithine deacetylase K01438; COG: COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases; Psort location: Cytoplasmic, score:8.96. (396 aa)
CKO_03054Hypothetical protein; KEGG: eco:b3940 0. metL, metM; aspartokinase II and homoserine dehydrogenase II K00003:K00928; COG: COG0527 Aspartokinases; Psort location: Cytoplasmic, score:8.96; In the C-terminal section; belongs to the homoserine dehydrogenase family. (810 aa)
CKO_03055Hypothetical protein; KEGG: eco:b3939 2.8e-198 metB, met-1, met1; cystathionine gamma-synthase K01739; COG: COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases; Psort location: Cytoplasmic, score:9.97. (386 aa)
tpiAHypothetical protein; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (249 aa)
pfkAHypothetical protein; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (320 aa)
CKO_03140Hypothetical protein; KEGG: sdy:SDY_3873 1.3e-250 glnA; glutamine synthetase K01915; COG: COG0174 Glutamine synthetase; Psort location: Cytoplasmic, score:9.97. (477 aa)
dapDHypothetical protein; KEGG: spt:SPA0219 1.1e-141 dapD; 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase K00674; COG: COG2171 Tetrahydrodipicolinate N-succinyltransferase; Psort location: Cytoplasmic, score:9.97; Belongs to the transferase hexapeptide repeat family. (274 aa)
mtnNHypothetical protein; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation. Belongs to the PNP/UDP phosphorylas [...] (232 aa)
CKO_03252Hypothetical protein; KEGG: sec:SC0157 0. acnB; aconitate hydratase 2 K01682; COG: COG1049 Aconitase B; Psort location: Cytoplasmic, score:8.96; Belongs to the aconitase/IPM isomerase family. (874 aa)
CKO_03300Hypothetical protein; KEGG: eci:UTI89_C0086 3.5e-81 ilvH; acetolactate synthase III, valine sensitive, small subunit K01653; COG: COG0440 Acetolactate synthase, small (regulatory) subunit; Psort location: Cytoplasmic, score:8.96. (173 aa)
CKO_03301Hypothetical protein; KEGG: ssn:SSO_0084 8.0e-297 ilvI; acetolactate synthase isozyme III large subunit K01652; COG: COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. (574 aa)
leuAHypothetical protein; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (523 aa)
leuBHypothetical protein; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (363 aa)
leuCHypothetical protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (466 aa)
leuDHypothetical protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa)
dapBHypothetical protein; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (273 aa)
tal-2Hypothetical protein; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (317 aa)
CKO_03383Hypothetical protein; KEGG: sbo:SBO_0003 1.6e-213 thrC; threonine synthase K01733; COG: COG0498 Threonine synthase; Psort location: Cytoplasmic, score:8.96. (428 aa)
thrBHypothetical protein; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (309 aa)
CKO_03385Hypothetical protein; KEGG: sec:SC0002 0. thrA; aspartokinase I K00003:K00928; COG: COG0527 Aspartokinases; Psort location: Cytoplasmic, score:8.96; In the C-terminal section; belongs to the homoserine dehydrogenase family. (820 aa)
gpmBHypothetical protein; KEGG: stm:STM4585 5.6e-106 gpmB; putative phosphoglyceromutase 2 K01834; COG: COG0406 Fructose-2,6-bisphosphatase; Psort location: Cytoplasmic, score:8.96; Belongs to the phosphoglycerate mutase family. GpmB subfamily. (215 aa)
CKO_03400Hypothetical protein; KEGG: ecc:c5473 2.5e-167 serB; phosphoserine phosphatase K01079; COG: COG0560 Phosphoserine phosphatase. (334 aa)
CKO_03454Hypothetical protein; KEGG: sfl:SF3053 3.6e-159 metC; cystathionine beta-lyase K01760; COG: COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases; Psort location: Cytoplasmic, score:9.26. (396 aa)
argIHypothetical protein; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (334 aa)
argI-2Hypothetical protein; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (334 aa)
CKO_03782Hypothetical protein; KEGG: eco:b4090 3.5e-65 rpiB, yjcA, alsI; ribose 5-phosphate isomerase B K01808; COG: COG0698 Ribose 5-phosphate isomerase RpiB. (151 aa)
CKO_03797Hypothetical protein; KEGG: ecs:ECs5069 3.9e-137 putative fructose-bisphosphate aldolase K01624; COG: COG0191 Fructose/tagatose bisphosphate aldolase; Psort location: Cytoplasmic, score:8.96. (286 aa)
CKO_03855Hypothetical protein; KEGG: eco:b4054 8.6e-197 tyrB; tyrosine aminotransferase, tyrosine repressible K00832; COG: COG1448 Aspartate/tyrosine/aromatic aminotransferase; Psort location: Cytoplasmic, score:9.97. (397 aa)
CKO_03894Hypothetical protein; KEGG: eco:b4024 3.1e-215 lysC, apk; aspartate kinase III K00928; COG: COG0527 Aspartokinases; Belongs to the aspartokinase family. (453 aa)
CKO_03902Hypothetical protein; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1247 aa)
metASHypothetical protein; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. (309 aa)
CKO_03919Hypothetical protein; KEGG: ecj:JW2580 5.1e-192 pheA; fused chorismate mutase P and prephenate dehydratase K04093:K04518; COG: COG0077 Prephenate dehydratase; Psort location: Cytoplasmic, score:9.97. (409 aa)
CKO_03920Hypothetical protein; KEGG: sty:STY2856 6.9e-188 tyrA; prephenate dehydrogenase / chorismate mutase K04092:K04517; COG: COG0287 Prephenate dehydrogenase; Psort location: Cytoplasmic, score:8.96. (373 aa)
CKO_03921Hypothetical protein; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (356 aa)
luxSHypothetical protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (171 aa)
eno-2Hypothetical protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (432 aa)
CKO_04154Hypothetical protein; KEGG: stm:STM2971 1.4e-235 sdaB; L-serine dehydratase (L-threonine deaminase 2) K01752; COG: COG1760 L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (455 aa)
argAHypothetical protein; KEGG: ecj:JW2786 1.3e-211 argA; fused acetylglutamate kinase homolog (inactive) and amino acid N-acetyltransferase K00619; COG: COG0548 Acetylglutamate kinase; Psort location: Cytoplasmic, score:8.96; Belongs to the acetyltransferase family. ArgA subfamily. (413 aa)
lysAHypothetical protein; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (420 aa)
CKO_04278Hypothetical protein; KEGG: eco:b2913 5.8e-207 serA; D-3-phosphoglycerate dehydrogenase K00058; COG: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Psort location: Cytoplasmic, score:9.97; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (410 aa)
rpiAHypothetical protein; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (231 aa)
CKO_04295Hypothetical protein; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (359 aa)
pgkHypothetical protein; KEGG: ecc:c3504 4.2e-197 pgk; phosphoglycerate kinase K00927; COG: COG0126 3-phosphoglycerate kinase; Psort location: Cytoplasmic, score:9.26. (404 aa)
CKO_04309Hypothetical protein; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (673 aa)
metKHypothetical protein; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (384 aa)
CKO_04402Hypothetical protein; KEGG: ecc:c3742 8.1e-201 metC; cystathionine beta-lyase K01760; COG: COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases; Psort location: Cytoplasmic, score:9.26. (421 aa)
CKO_04512Hypothetical protein; KEGG: spt:SPA3109 1.8e-221 tdcG; L-serine dehydratase K01752; COG: COG1760 L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (454 aa)
CKO_04517Hypothetical protein; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (329 aa)
CKO_04539Hypothetical protein; KEGG: ecc:c1175 1.0e-184 putative aminotransferase K00842; COG: COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities; Psort location: Cytoplasmic, score:8.96. (390 aa)
argGHypothetical protein; KEGG: sty:STY3470 1.8e-237 argG; argininosuccinate synthetase K01940; COG: COG0137 Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (447 aa)
CKO_04620Hypothetical protein; KEGG: sbo:SBO_3170 0. gltB; glutamate synthase, large subunit K00265; COG: COG0069 Glutamate synthase domain 2; Psort location: Cytoplasmic, score:8.96. (1498 aa)
CKO_04622Hypothetical protein; KEGG: sty:STY3511 2.6e-250 gltD; glutamate synthase (NADPH) small chain K00266; COG: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases; Psort location: Cytoplasmic, score:9.97. (472 aa)
aroQHypothetical protein; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (150 aa)
aroEHypothetical protein; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (272 aa)
argDHypothetical protein; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (405 aa)
CKO_04807Hypothetical protein; KEGG: eci:UTI89_C3884 2.7e-113 rpe; D-ribulose-5-phosphate 3-epimerase K01783; COG: COG0036 Pentose-5-phosphate-3-epimerase; Psort location: Cytoplasmic, score:8.96; Belongs to the ribulose-phosphate 3-epimerase family. (225 aa)
aroBHypothetical protein; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (362 aa)
aroK-2Hypothetical protein; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (173 aa)
asdHypothetical protein; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (368 aa)
CKO_05064Hypothetical protein; KEGG: sdy:SDY_4040 2.0e-142 cysE; serine acetyltransferase K00640; COG: COG1045 Serine acetyltransferase; Psort location: Cytoplasmic, score:9.26; Belongs to the transferase hexapeptide repeat family. (273 aa)
gpmIHypothetical protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (507 aa)
Your Current Organism:
Citrobacter koseri
NCBI taxonomy Id: 290338
Other names: C. koseri ATCC BAA-895, Citrobacter (diversus) koseri ATCC BAA-895, Citrobacter koseri ATCC BAA-895, Citrobacter koseri str. ATCC BAA-895, Citrobacter koseri strain ATCC BAA-895
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