STRINGSTRING
yidC yidC tatA tatA tatB tatB tatC tatC CKO_00886 CKO_00886 CKO_00889 CKO_00889 CKO_00890 CKO_00890 CKO_00891 CKO_00891 CKO_00893 CKO_00893 CKO_00895 CKO_00895 CKO_00896 CKO_00896 CKO_00897 CKO_00897 CKO_00898 CKO_00898 CKO_02218 CKO_02218 CKO_02219 CKO_02219 CKO_02220 CKO_02220 CKO_02221 CKO_02221 CKO_02222 CKO_02222 CKO_02223 CKO_02223 CKO_02224 CKO_02224 CKO_02225 CKO_02225 CKO_02226 CKO_02226 CKO_02227 CKO_02227 CKO_02228 CKO_02228 CKO_02229 CKO_02229 tatE tatE secF secF secD secD yajC yajC secE secE secA secA secM secM ffh ffh CKO_04357 CKO_04357 CKO_04361 CKO_04361 CKO_04427 CKO_04427 CKO_04576 CKO_04576 secY secY ftsY ftsY secB secB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
yidCHypothetical protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. (548 aa)
tatAHypothetical protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. (88 aa)
tatBHypothetical protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. (182 aa)
tatCHypothetical protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. (259 aa)
CKO_00886Hypothetical protein; Part of the Type IV secretion system. Belongs to the GSP E family. (341 aa)
CKO_00889Hypothetical protein; COG: COG2948 Type IV secretory pathway, VirB10 components. (414 aa)
CKO_00890Hypothetical protein; COG: COG3504 Type IV secretory pathway, VirB9 components. (302 aa)
CKO_00891Hypothetical protein; COG: COG3736 Type IV secretory pathway, component VirB8. (227 aa)
CKO_00893Hypothetical protein; COG: COG3704 Type IV secretory pathway, VirB6 components; Psort location: CytoplasmicMembrane, score:10.00. (357 aa)
CKO_00895Hypothetical protein; COG: NOG13363 non supervised orthologous group. (235 aa)
CKO_00896Hypothetical protein; COG: COG3451 Type IV secretory pathway, VirB4 components. (912 aa)
CKO_00897Hypothetical protein; COG: NOG22876 non supervised orthologous group; Psort location: CytoplasmicMembrane, score:9.50. (97 aa)
CKO_00898Hypothetical protein; COG: NOG17192 non supervised orthologous group; Psort location: Cytoplasmic, score:8.96. (236 aa)
CKO_02218Hypothetical protein; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. (265 aa)
CKO_02219Hypothetical protein; COG: COG3149 Type II secretory pathway, component PulM. (161 aa)
CKO_02220Hypothetical protein; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. (381 aa)
CKO_02221Hypothetical protein; COG: COG3156 Type II secretory pathway, component PulK. (338 aa)
CKO_02222Hypothetical protein; COG: COG4795 Type II secretory pathway, component PulJ. (221 aa)
CKO_02223Hypothetical protein; COG: COG2165 Type II secretory pathway, pseudopilin PulG. (126 aa)
CKO_02224Hypothetical protein; COG: COG2165 Type II secretory pathway, pseudopilin PulG. (161 aa)
CKO_02225Hypothetical protein; COG: COG2165 Type II secretory pathway, pseudopilin PulG. (149 aa)
CKO_02226Hypothetical protein; COG: COG1459 Type II secretory pathway, component PulF; Psort location: CytoplasmicMembrane, score:10.00. (402 aa)
CKO_02227Hypothetical protein; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. (492 aa)
CKO_02228Hypothetical protein; COG: COG1450 Type II secretory pathway, component PulD; Psort location: OuterMembrane, score:10.00. (640 aa)
CKO_02229Hypothetical protein; KEGG: rme:Rmet_2422 0.0046 peptidase S1C, Do K04771; COG: COG3031 Type II secretory pathway, component PulC; Psort location: CytoplasmicMembrane, score:9.82. (257 aa)
tatEHypothetical protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA; Belongs to the TatA/E family. TatE subfamily. (67 aa)
secFHypothetical protein; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (338 aa)
secDHypothetical protein; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (604 aa)
yajCHypothetical protein; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. (110 aa)
secEHypothetical protein; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation; Belongs to the SecE/SEC61-gamma family. (127 aa)
secAHypothetical protein; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. (901 aa)
secMHypothetical protein; Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation. Belongs to the SecM family. (145 aa)
ffhHypothetical protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components; Belongs to [...] (453 aa)
CKO_04357Hypothetical protein; COG: COG3157 Hemolysin-coregulated protein (uncharacterized); Psort location: Cytoplasmic, score:8.96. (83 aa)
CKO_04361COG: COG3501 Uncharacterized protein conserved in bacteria. (666 aa)
CKO_04427COG: COG1538 Outer membrane protein; Psort location: OuterMembrane, score:10.00. (489 aa)
CKO_04576Hypothetical protein; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. (110 aa)
secYHypothetical protein; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (443 aa)
ftsYHypothetical protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. (500 aa)
secBHypothetical protein; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. (155 aa)
Your Current Organism:
Citrobacter koseri
NCBI taxonomy Id: 290338
Other names: C. koseri ATCC BAA-895, Citrobacter (diversus) koseri ATCC BAA-895, Citrobacter koseri ATCC BAA-895, Citrobacter koseri str. ATCC BAA-895, Citrobacter koseri strain ATCC BAA-895
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