STRINGSTRING
dnaN dnaN recF recF radA radA recR recR dnaX dnaX AAur_0837 AAur_0837 AAur_0887 AAur_0887 AAur_0950 AAur_0950 mfd mfd dnaG dnaG recA recA recX recX miaB miaB miaA miaA AAur_1601 AAur_1601 dnaE dnaE uvrA uvrA polA polA uvrB uvrB uvrA-2 uvrA-2 uvrC uvrC AAur_2199 AAur_2199 recO recO holA holA priA priA ruvB ruvB ruvA ruvA ruvC ruvC AAur_2300 AAur_2300 AAur_2400 AAur_2400 AAur_2557 AAur_2557 sbcD sbcD AAur_2564 AAur_2564 AAur_2577 AAur_2577 AAur_2736 AAur_2736 AAur_2739 AAur_2739 AAur_2740 AAur_2740 AAur_2741 AAur_2741 AAur_2742 AAur_2742 xseA xseA xseB xseB deaD deaD topA topA AAur_3569 AAur_3569 dnaB dnaB ssb ssb
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dnaNDNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (374 aa)
recFPutative DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. (399 aa)
radADNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (457 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (199 aa)
dnaXDNA polymerase III, subunits gamma and tau; Identified by match to protein family HMM PF00004; match to protein family HMM TIGR02397. (1028 aa)
AAur_0837Putative ATP-dependent DNA helicase, RecQ family; Identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM TIGR00614. (721 aa)
AAur_0887Putative DNA polymerase III, delta' subunit. (383 aa)
AAur_0950ATP-dependent DNA helicase, RecQ family; Identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM TIGR00614. (554 aa)
mfdTranscription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1210 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (627 aa)
recArecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (347 aa)
recXPutative regulatory protein RecX; Modulates RecA activity; Belongs to the RecX family. (180 aa)
miaBtRNA-i(6)A37 thiotransferase; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (515 aa)
miaAtRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (308 aa)
AAur_1601ATP-dependent helicase,-like protein; Identified by similarity to GB:AAS04748.1. (686 aa)
dnaEDNA polymerase III, alpha subunit; Identified by similarity to SP:P10443; match to protein family HMM PF01336; match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594. (1186 aa)
uvrAExcinuclease ABC, A subunit; Identified by match to protein family HMM PF00005; match to protein family HMM TIGR00630. (887 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (880 aa)
uvrBExcinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (699 aa)
uvrA-2Excinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (975 aa)
uvrCExcinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (671 aa)
AAur_2199Putative excinuclease ABC, A subunit; Identified by match to protein family HMM PF00005. (798 aa)
recOPutative DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (277 aa)
holADNA polymerase III, delta subunit; Identified by match to protein family HMM PF06144; match to protein family HMM TIGR01128. (308 aa)
priAPutative primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (698 aa)
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (358 aa)
ruvAHolliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (231 aa)
ruvCCrossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (189 aa)
AAur_2300Putative Domain of unknown function DUF28; Identified by match to protein family HMM PF01709; match to protein family HMM TIGR01033. (251 aa)
AAur_2400Putative single-strand binding protein (SSB) (Helix-destabilizing protein); Identified by match to protein family HMM PF00436; match to protein family HMM TIGR00621. (183 aa)
AAur_2557Putative nuclease sbcCD subunit C; Identified by match to protein family HMM PF02463. (1004 aa)
sbcDPutative nuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (396 aa)
AAur_2564Putative DNA polymerase III epsilon subunit; Identified by match to protein family HMM PF00533; match to protein family HMM PF00929. (336 aa)
AAur_2577Putative DNA or RNA helicase of superfamily II; Identified by match to protein family HMM PF00271; match to protein family HMM PF04851. (591 aa)
AAur_2736Putative ATP-dependent DNA helicase (UvrD/REP); Identified by match to protein family HMM PF00570; match to protein family HMM PF00580. (721 aa)
AAur_2739UvrD/REP helicase; Identified by match to protein family HMM PF00580; Belongs to the helicase family. UvrD subfamily. (1167 aa)
AAur_2740Putative ATP-dependent DNA helicase (UvrD/REP); Identified by match to protein family HMM PF00580. (1118 aa)
AAur_2741Putative Methylated-DNA--protein-cysteine methyltransferase; Identified by match to protein family HMM PF01035. (138 aa)
AAur_2742Putative DNA polymerase III epsilon subunit; Identified by match to protein family HMM PF00929. (236 aa)
xseAExodeoxyribonuclease VII, large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (425 aa)
xseBExodeoxyribonuclease VII, small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (82 aa)
deaDPutative ATP-dependent RNA helicase; DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation. (726 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (907 aa)
AAur_3569Putative helicase/SNF2 family domain protein; Identified by match to protein family HMM PF00176; match to protein family HMM PF00271; match to protein family HMM PF04434. (1151 aa)
dnaBReplicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (462 aa)
ssbSingle-strand binding protein; Identified by similarity to SP:P37455; match to protein family HMM PF00436; match to protein family HMM PF01336; match to protein family HMM TIGR00621. (193 aa)
Your Current Organism:
Paenarthrobacter aurescens
NCBI taxonomy Id: 290340
Other names: Arthrobacter aurescens TC1, P. aurescens TC1, Paenarthrobacter aurescens TC1
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.