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| | dnaE | DNA polymerase III, alpha subunit; Identified by similarity to SP:P10443; match to protein family HMM PF01336; match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594. (1186 aa) |
| | dinB | Putative DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (384 aa) |
| | cmk | Cytidylate kinase; Identified by match to protein family HMM PF02224; match to protein family HMM TIGR00017. (237 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (581 aa) |
| | ppnK | ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (346 aa) |
| | AAur_1590 | Putative competence/damage-inducible protein CinA; Identified by match to protein family HMM PF02464; match to protein family HMM TIGR00199; Belongs to the CinA family. (119 aa) |
| | ribF | Riboflavin biosynthesis protein RibF; Identified by match to protein family HMM PF01687; match to protein family HMM PF06574; match to protein family HMM TIGR00083; Belongs to the ribF family. (327 aa) |
| | nusA | Transcription termination factor NusA; Participates in both transcription termination and antitermination. (326 aa) |
| | AAur_1521 | Pyruvate dehydrogenase E1 component, alpha subunit; Identified by match to protein family HMM PF00676. (365 aa) |
| | AAur_1516 | Putative DNA polymerase beta chain; Identified by match to protein family HMM PF02811. (339 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (276 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (627 aa) |
| | AAur_1436 | Conserved hypothetical protein. (402 aa) |
| | AAur_1422 | Putative adenylate cyclase; Identified by match to protein family HMM PF00211. (392 aa) |
| | AAur_1395 | Identified by match to protein family HMM PF00817. (400 aa) |
| | acsA | acetate--CoA ligase; Identified by match to protein family HMM PF00501; match to protein family HMM TIGR02188. (670 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (326 aa) |
| | glmU | Putative UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (497 aa) |
| | AAur_1309 | Conserved hypothetical protein; Identified by match to protein family HMM TIGR03089. (231 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (395 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (187 aa) |
| | manA | Mannose-6-phosphate isomerase, class I; Identified by match to protein family HMM PF01238; match to protein family HMM TIGR00218. (416 aa) |
| | add-2 | Adenosine deaminase; Identified by match to protein family HMM PF00962; match to protein family HMM TIGR01430. (380 aa) |
| | folD2 | Putative tetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (297 aa) |
| | purU-2 | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (311 aa) |
| | purH | Bifunctional purine biosynthesis protein PurH; Identified by match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355. (556 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (189 aa) |
| | AAur_1182 | UDP-glucose 6-dehydrogenase; Identified by match to protein family HMM PF00984; match to protein family HMM PF02737; match to protein family HMM PF03720; match to protein family HMM PF03721; match to protein family HMM TIGR03026. (461 aa) |
| | AAur_1158 | Putative RNA polymerase sigma (70) factor; Identified by match to protein family HMM PF04542; match to protein family HMM PF04545; match to protein family HMM TIGR02937; Belongs to the sigma-70 factor family. ECF subfamily. (548 aa) |
| | AAur_0897 | Putative CarD-like transcriptional regulator; Identified by match to protein family HMM PF02559. (160 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (229 aa) |
| | AAur_0887 | Putative DNA polymerase III, delta' subunit. (383 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (211 aa) |
| | AAur_0790 | Putative 6-pyruvoyl tetrahydropterin synthase. (132 aa) |
| | AAur_0761 | Conserved hypothetical protein; Identified by match to protein family HMM PF02222; match to protein family HMM PF02655. (303 aa) |
| | AAur_0759 | Putative Sigma-70 region 2 domain protein; Identified by match to protein family HMM PF04542; match to protein family HMM TIGR02937; Belongs to the sigma-70 factor family. ECF subfamily. (548 aa) |
| | AAur_0735 | Putative integral membrane protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (236 aa) |
| | dnaX | DNA polymerase III, subunits gamma and tau; Identified by match to protein family HMM PF00004; match to protein family HMM TIGR02397. (1028 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, purS protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (83 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (256 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (769 aa) |
| | AAur_0606 | Putative RNA polymerase sigma (70) factor; Identified by match to protein family HMM PF04542; match to protein family HMM PF04545; match to protein family HMM TIGR02937; Belongs to the sigma-70 factor family. ECF subfamily. (184 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (429 aa) |
| | AAur_0544 | Flavoprotein domain protein; Identified by match to protein family HMM PF02441. (217 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (190 aa) |
| | nadE | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (273 aa) |
| | AAur_0509 | Putative acetyl-CoA synthetase; Identified by match to protein family HMM PF00501. (572 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (304 aa) |
| | folD | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (294 aa) |
| | AAur_0455 | Putative RNA polymerase ECF-subfamily sigma factor; Identified by match to protein family HMM PF04542; match to protein family HMM PF04545; match to protein family HMM TIGR02937; Belongs to the sigma-70 factor family. ECF subfamily. (192 aa) |
| | AAur_0283 | ATP-dependent DNA ligase domain protein; Identified by match to protein family HMM PF01068; match to protein family HMM PF04679; match to protein family HMM TIGR02777; match to protein family HMM TIGR02778; match to protein family HMM TIGR02779. (851 aa) |
| | AAur_0263 | Putative RNA polymerase sigma (70) factor; Identified by match to protein family HMM PF04542; match to protein family HMM TIGR02937; Belongs to the sigma-70 factor family. ECF subfamily. (534 aa) |
| | AAur_0223 | Putative RNA polymerase sigma (70) factor; Identified by match to protein family HMM PF04542; match to protein family HMM PF04545; match to protein family HMM TIGR02937; Belongs to the sigma-70 factor family. ECF subfamily. (169 aa) |
| | hpt | Hypoxanthine phosphoribosyltransferase; Identified by match to protein family HMM PF00156; match to protein family HMM TIGR01203; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (183 aa) |
| | AAur_0119 | ADP-heptose synthase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (525 aa) |
| | rfaE | rfaE bifunctional protein; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (469 aa) |
| | AAur_0109 | Putative RNA polymerase sigma (70) factor; Identified by match to protein family HMM PF04539; match to protein family HMM PF04542; match to protein family HMM PF04545; match to protein family HMM TIGR02937; Belongs to the sigma-70 factor family. (258 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (426 aa) |
| | AAur_0040 | Putative RNA polymerase sigma (70) factor; Identified by match to protein family HMM PF04542; match to protein family HMM TIGR02937; Belongs to the sigma-70 factor family. ECF subfamily. (191 aa) |
| | AAur_0022 | Putative RNA polymerase sigma (70) factor; Identified by match to protein family HMM PF04542; match to protein family HMM TIGR02937; Belongs to the sigma-70 factor family. ECF subfamily. (170 aa) |
| | dnaN | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (374 aa) |
| | AAur_3170 | UDP-glucose 6-dehydrogenase; Identified by match to protein family HMM PF00984; match to protein family HMM PF03446; match to protein family HMM PF03720; match to protein family HMM PF03721; match to protein family HMM TIGR03026. (437 aa) |
| | rfbC/rfbD-2 | dTDP-4-keto-L-rhamnose reductase/dTDP-4-keto-6-deoxyglucose-3,5-epimerase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (477 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (267 aa) |
| | AAur_2983 | Conserved hypothetical protein; May play a role in the intracellular transport of hydrophobic ligands. (199 aa) |
| | fcl | GDP-fucose synthetase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (321 aa) |
| | AAur_4110 | UDP-glucose 6-dehydrogenase; Identified by match to protein family HMM PF00984; match to protein family HMM PF03720; match to protein family HMM PF03721; match to protein family HMM TIGR03026. (459 aa) |
| | dnaB | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (462 aa) |
| | AAur_4030 | Putative Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases; Identified by match to protein family HMM PF00501. (565 aa) |
| | AAur_4024 | Putative transcriptional regulator, PaaX-like protein family; Identified by match to protein family HMM PF07848; match to protein family HMM PF08223. (294 aa) |
| | AAur_3937 | Putative RNA polymerase sigma (70) factor; Identified by match to protein family HMM PF04542; match to protein family HMM TIGR02937; Belongs to the sigma-70 factor family. ECF subfamily. (199 aa) |
| | purB | Adenylosuccinate lyase; Identified by match to protein family HMM PF00206; match to protein family HMM TIGR00928; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (468 aa) |
| | AAur_3893 | Putative pyruvate dehydrogenase E1 (lipoamide) alpha subunit; Identified by match to protein family HMM PF00676. (396 aa) |
| | AAur_3872 | Putative RNA polymerase sigma (70) factor; Identified by match to protein family HMM PF04542; match to protein family HMM PF04545; match to protein family HMM TIGR02937; Belongs to the sigma-70 factor family. ECF subfamily. (190 aa) |
| | purU-3 | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (299 aa) |
| | dcd | Deoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (191 aa) |
| | AAur_3642 | Putative DNA polymerase IV; Identified by match to protein family HMM PF00817. (357 aa) |
| | AAur_3640 | Putative RNA polymerase sigma (70) factor; Identified by match to protein family HMM PF04542; match to protein family HMM TIGR02937; Belongs to the sigma-70 factor family. (392 aa) |
| | AAur_3561 | Putative RNA polymerase ECF-subfamily sigma factor; Identified by match to protein family HMM PF04542; match to protein family HMM PF04545; match to protein family HMM TIGR02937; Belongs to the sigma-70 factor family. ECF subfamily. (170 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase; Identified by match to protein family HMM PF00586; match to protein family HMM PF02769; match to protein family HMM TIGR00878. (350 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (542 aa) |
| | AAur_3505 | Hypothetical protein; Identified by Glimmer2; putative. (478 aa) |
| | AAur_3502 | Conserved hypothetical protein. (232 aa) |
| | AAur_3480 | Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (300 aa) |
| | AAur_3476 | Putative Thymidylate kinase. (193 aa) |
| | AAur_3454 | Identified by match to protein family HMM PF00293. (147 aa) |
| | adk-2 | Adenylate kinase (ATP-AMP transphosphorylase); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (213 aa) |
| | AAur_3417 | Putative glutamine amidotransferase; Identified by match to protein family HMM PF00117. (243 aa) |
| | purD | Phosphoribosylamine--glycine ligase; Identified by match to protein family HMM PF01071; match to protein family HMM PF02655; match to protein family HMM PF02843; match to protein family HMM PF02844; match to protein family HMM TIGR00877; Belongs to the GARS family. (452 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Identified by match to protein family HMM PF01259; match to protein family HMM TIGR00081; Belongs to the SAICAR synthetase family. (312 aa) |
| | acsA-2 | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (685 aa) |
| | AAur_3348 | Putative DNA polymerase I; Identified by match to protein family HMM PF00476. (563 aa) |
| | AAur_3279 | Conserved hypothetical protein. (146 aa) |
| | nusG | Transcription termination/antitermination factor NusG; Participates in transcription elongation, termination and antitermination. (300 aa) |
| | rpoB | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1173 aa) |
| | rpoC | DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1299 aa) |
| | adk | Adenylate kinase (ATP-AMP transphosphorylase); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (192 aa) |
| | rpoA | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (336 aa) |
| | coaA | Pantothenate kinase; Identified by match to protein family HMM PF00485; match to protein family HMM TIGR00554. (323 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (503 aa) |
| | AAur_2865 | Putative inosine-5'-monophosphate dehydrogenase; Identified by match to protein family HMM PF00478; match to protein family HMM TIGR01304. (378 aa) |
| | guaA | GMP synthase (Glutamine amidotransferase); Catalyzes the synthesis of GMP from XMP. (529 aa) |
| | AAur_2780 | Putative RNA polymerase ECF-subfamily sigma factor; Identified by match to protein family HMM PF04542; match to protein family HMM PF04545; match to protein family HMM TIGR02937; Belongs to the sigma-70 factor family. ECF subfamily. (207 aa) |
| | AAur_2718 | Putative RNA polymerase sigma (70) factor; Identified by match to protein family HMM PF04542; match to protein family HMM PF04545; match to protein family HMM TIGR02937; Belongs to the sigma-70 factor family. ECF subfamily. (238 aa) |
| | AAur_2641 | Putative RNA polymerase sigma (70) factor; Identified by match to protein family HMM PF04542; match to protein family HMM PF04545; match to protein family HMM TIGR02937; match to protein family HMM TIGR02947; Belongs to the sigma-70 factor family. ECF subfamily. (265 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (715 aa) |
| | atpB | ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (266 aa) |
| | atpE | ATP synthase subunit C; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (72 aa) |
| | atpF | ATP synthase F0, B subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (185 aa) |
| | atpA | ATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (556 aa) |
| | atpG | ATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (296 aa) |
| | atpD | ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (486 aa) |
| | AAur_2587 | Conserved hypothetical protein. (171 aa) |
| | AAur_2576 | Nicotinamidase/pyrazinamidase; Identified by match to protein family HMM PF00857. (208 aa) |
| | AAur_2575 | Putative nicotinate phosphoribosyltransferase (pncB); Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (442 aa) |
| | AAur_2546 | Conserved hypothetical protein. (300 aa) |
| | AAur_2538 | Putative pyruvate dehydrogenase E1 (lipoamide) alpha subunit; Identified by match to protein family HMM PF00676. (356 aa) |
| | nadA | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (435 aa) |
| | nadB | L-aspartate oxidase; Identified by match to protein family HMM PF00890; match to protein family HMM PF01266; match to protein family HMM PF02910; match to protein family HMM PF07992; match to protein family HMM TIGR00551. (620 aa) |
| | nadC | Nicotinate-nucleotide pyrophosphorylase; Identified by match to protein family HMM PF01729; match to protein family HMM PF02749; match to protein family HMM TIGR00078; Belongs to the NadC/ModD family. (292 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (441 aa) |
| | coaD | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (166 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (168 aa) |
| | nadD | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (206 aa) |
| | AAur_2338 | Ribonucleoside-diphosphate reductase beta chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (324 aa) |
| | AAur_2310 | Putative DNA polymerase III, alpha subunit; Identified by match to protein family HMM PF01336; match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594; Belongs to the DNA polymerase type-C family. DnaE2 subfamily. (1172 aa) |
| | AAur_2293 | Putative GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (802 aa) |
| | nusB | Transcription antitermination factor NusB; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (136 aa) |
| | pyrB | Aspartate carbamoyltransferase; Identified by match to protein family HMM PF00185; match to protein family HMM PF02729; match to protein family HMM TIGR00670; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (335 aa) |
| | pyrC | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (441 aa) |
| | AAur_2267 | Conserved hypothetical protein. (173 aa) |
| | carA | Carbamoyl-phosphate synthase, small subunit; Identified by match to protein family HMM PF00117; match to protein family HMM PF00988; match to protein family HMM TIGR01368; Belongs to the CarA family. (415 aa) |
| | carB | Carbamoyl-phosphate synthase, large subunit; Identified by match to protein family HMM PF00289; match to protein family HMM PF02142; match to protein family HMM PF02786; match to protein family HMM PF02787; match to protein family HMM TIGR01369. (1102 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Identified by match to protein family HMM PF00215; match to protein family HMM TIGR02127; Belongs to the OMP decarboxylase family. Type 2 subfamily. (291 aa) |
| | gmk | Putative Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (190 aa) |
| | rpoZ | DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (86 aa) |
| | coaBC | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (418 aa) |
| | AAur_2232 | Hypothetical protein; Identified by Glimmer2; putative. (403 aa) |
| | pyrD | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (384 aa) |
| | rfbC/rfbD | dTDP-4-keto-L-rhamnose reductase/dTDP-4-keto-6-deoxyglucose-3,5-epimerase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (469 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (412 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (880 aa) |
| | AAur_2057 | Putative kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (412 aa) |
| | AAur_2056 | Putative transcriptional regulator, PaaX-like protein family; Identified by match to protein family HMM PF07848; match to protein family HMM PF08223. (315 aa) |
| | AAur_2048 | Conserved hypothetical protein; Identified by match to protein family HMM TIGR02778. (343 aa) |
| | AAur_2036 | Putative RNA polymerase sigma (70) factor; Identified by match to protein family HMM PF04542; match to protein family HMM TIGR02937; Belongs to the sigma-70 factor family. (419 aa) |
| | AAur_2030 | Conserved hypothetical protein. (480 aa) |
| | AAur_2008 | Conserved hypothetical protein; Identified by match to protein family HMM TIGR02778. (414 aa) |
| | AAur_1938 | Putative homoserine dehydrogenase, NAD binding domain protein; Identified by match to protein family HMM PF01958; match to protein family HMM PF03447. (265 aa) |
| | AAur_1911 | Putative RNA polymerase sigma factor domain protein; Identified by match to protein family HMM PF04542; match to protein family HMM TIGR02937; Belongs to the sigma-70 factor family. ECF subfamily. (556 aa) |
| | dut | Putative deoxyuridine 5'-triphosphate nucleotidohydrolase (dut); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (196 aa) |
| | tdk | Thymidine kinase; Identified by match to protein family HMM PF00265. (242 aa) |
| | rpoD | RNA polymerase sigma (70) factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (437 aa) |
