(14 nodes) Serine/threonine dehydratase, pyridoxal-phosphate-binding site, and Cysteine metabolic process network (Jannaschia sp. CCS1)

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Your Input:
	ilvA	L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (425 aa)
	Jann_0252	Phosphoserine phosphatase. (291 aa)
	Jann_0316	L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (470 aa)
	Jann_1648	Serine O-acetyltransferase. (272 aa)
	Jann_1660	Pyridoxal-5'-phosphate-dependent enzyme beta subunit. (324 aa)
	metZ	O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (397 aa)
	cysS	cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (453 aa)
	Jann_1993	Pyridoxal-5'-phosphate-dependent enzyme beta subunit. (341 aa)
	metAA	Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (313 aa)
	Jann_2721	O-acetylhomoserine sulfhydrolase. (430 aa)
	Jann_2738	L-threonine ammonia-lyase. (317 aa)
	Jann_2851	L-threonine aldolase. (343 aa)
	Jann_3149	L-threonine synthase. (462 aa)
	Jann_3189	Pyridoxal-5'-phosphate-dependent enzyme beta subunit. (323 aa)

Your Current Organism:

Jannaschia sp. CCS1

NCBI taxonomy Id: 290400
Other names: J. sp. CCS1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Jann_0252	Jann_0316	Jann_0252	Jann_0316	Phosphoserine phosphatase.	L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	0.916
Jann_0252	Jann_1648	Jann_0252	Jann_1648	Phosphoserine phosphatase.	Serine O-acetyltransferase.	0.859
Jann_0252	Jann_1660	Jann_0252	Jann_1660	Phosphoserine phosphatase.	Pyridoxal-5'-phosphate-dependent enzyme beta subunit.	0.905
Jann_0252	Jann_2738	Jann_0252	Jann_2738	Phosphoserine phosphatase.	L-threonine ammonia-lyase.	0.905
Jann_0252	Jann_3189	Jann_0252	Jann_3189	Phosphoserine phosphatase.	Pyridoxal-5'-phosphate-dependent enzyme beta subunit.	0.905
Jann_0252	ilvA	Jann_0252	Jann_0069	Phosphoserine phosphatase.	L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.	0.905
Jann_0252	metAA	Jann_0252	Jann_2351	Phosphoserine phosphatase.	Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family.	0.807
Jann_0316	Jann_0252	Jann_0316	Jann_0252	L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	Phosphoserine phosphatase.	0.916
Jann_0316	Jann_1648	Jann_0316	Jann_1648	L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	Serine O-acetyltransferase.	0.915
Jann_0316	Jann_1660	Jann_0316	Jann_1660	L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	Pyridoxal-5'-phosphate-dependent enzyme beta subunit.	0.835
Jann_0316	Jann_2738	Jann_0316	Jann_2738	L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	L-threonine ammonia-lyase.	0.835
Jann_0316	Jann_3189	Jann_0316	Jann_3189	L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	Pyridoxal-5'-phosphate-dependent enzyme beta subunit.	0.835
Jann_0316	ilvA	Jann_0316	Jann_0069	L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.	0.835
Jann_0316	metAA	Jann_0316	Jann_2351	L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family.	0.818
Jann_1648	Jann_0252	Jann_1648	Jann_0252	Serine O-acetyltransferase.	Phosphoserine phosphatase.	0.859
Jann_1648	Jann_0316	Jann_1648	Jann_0316	Serine O-acetyltransferase.	L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	0.915
Jann_1648	Jann_1660	Jann_1648	Jann_1660	Serine O-acetyltransferase.	Pyridoxal-5'-phosphate-dependent enzyme beta subunit.	0.808
Jann_1648	Jann_1993	Jann_1648	Jann_1993	Serine O-acetyltransferase.	Pyridoxal-5'-phosphate-dependent enzyme beta subunit.	0.988
Jann_1648	Jann_2721	Jann_1648	Jann_2721	Serine O-acetyltransferase.	O-acetylhomoserine sulfhydrolase.	0.641
Jann_1648	Jann_2738	Jann_1648	Jann_2738	Serine O-acetyltransferase.	L-threonine ammonia-lyase.	0.808