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pckA pckA Jann_0804 Jann_0804 Jann_0809 Jann_0809 Jann_0810 Jann_0810 Jann_0811 Jann_0811 mdh mdh sucC sucC sucD sucD Jann_0831 Jann_0831 Jann_0832 Jann_0832 Jann_0837 Jann_0837 Jann_1688 Jann_1688 Jann_1690 Jann_1690 pdhA pdhA Jann_1720 Jann_1720 Jann_1841 Jann_1841 Jann_2371 Jann_2371 Jann_2372 Jann_2372 fumC fumC Jann_2646 Jann_2646 Jann_2781 Jann_2781 Jann_3557 Jann_3557 Jann_3768 Jann_3768 Jann_3966 Jann_3966 Jann_3967 Jann_3967 Jann_3968 Jann_3968 Jann_3969 Jann_3969
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pckAPhosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (535 aa)
Jann_0804Succinate dehydrogenase subunit B; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (264 aa)
Jann_0809Succinate dehydrogenase subunit A; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (606 aa)
Jann_0810Succinate dehydrogenase subunit D. (123 aa)
Jann_0811Succinate dehydrogenase subunit C. (127 aa)
mdhMalate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (320 aa)
sucCsuccinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (397 aa)
sucDsuccinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (293 aa)
Jann_08312-oxoglutarate dehydrogenase E1 component. (985 aa)
Jann_08322-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (507 aa)
Jann_0837Dihydrolipoamide dehydrogenase. (462 aa)
Jann_1688Dihydrolipoamide acetyltransferase long form; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (441 aa)
Jann_1690Transketolase protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (464 aa)
pdhAPyruvate dehydrogenase (lipoamide); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (347 aa)
Jann_1720Dihydrolipoamide dehydrogenase. (465 aa)
Jann_1841Citrate synthase; Belongs to the citrate synthase family. (430 aa)
Jann_2371Isocitrate dehydrogenase NADP-dependent; Belongs to the monomeric-type IDH family. (731 aa)
Jann_2372Isocitrate dehydrogenase (NADP); Belongs to the isocitrate and isopropylmalate dehydrogenases family. (404 aa)
fumCFumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (462 aa)
Jann_2646Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (931 aa)
Jann_2781Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1146 aa)
Jann_3557Transketolase protein; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (795 aa)
Jann_3768Fumarate reductase/succinate dehydrogenase flavoprotein-like protein. (460 aa)
Jann_3966Succinate dehydrogenase subunit B. (237 aa)
Jann_3967Hypothetical protein. (113 aa)
Jann_3968Succinate dehydrogenase subunit C. (114 aa)
Jann_3969L-aspartate oxidase. (585 aa)
Your Current Organism:
Jannaschia sp. CCS1
NCBI taxonomy Id: 290400
Other names: J. sp. CCS1
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