STRINGSTRING
BCR BCR CRKL CRKL CBLB CBLB LOC103658503 LOC103658503 GRB2 GRB2 PTPN11 PTPN11 CRK CRK SH3KBP1 SH3KBP1 FGR FGR SOS1 SOS1 SHC4 SHC4 BCAR1 BCAR1 SPRY2 SPRY2 GAB1 GAB1 SHC3 SHC3 RAPGEF1 RAPGEF1 SH3GL2 SH3GL2 ABL1 ABL1 SHC1 SHC1 FRS2 FRS2 MST1R MST1R CBLC CBLC CBL CBL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BCRBCR activator of RhoGEF and GTPase. (1162 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
CBLBE3 ubiquitin-protein ligase CBL-B isoform X1. (983 aa)
LOC103658503GRB2-related adapter protein. (225 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (600 aa)
CRKAdapter molecule crk. (287 aa)
SH3KBP1SH3 domain-containing kinase-binding protein 1 isoform X1. (629 aa)
FGRTyrosine-protein kinase. (577 aa)
SOS1Son of sevenless homolog 1. (1276 aa)
SHC4SHC-transforming protein 4. (630 aa)
BCAR1Breast cancer anti-estrogen resistance protein 1. (862 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
GAB1GRB2-associated-binding protein 1. (722 aa)
SHC3SHC-transforming protein 3 isoform X2. (425 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1230 aa)
SH3GL2endophilin-A1. (237 aa)
ABL1Tyrosine-protein kinase. (1135 aa)
SHC1LOW QUALITY PROTEIN: SHC-transforming protein 1. (569 aa)
FRS2Fibroblast growth factor receptor substrate 2. (507 aa)
MST1RMacrophage-stimulating protein receptor. (1350 aa)
CBLCE3 ubiquitin-protein ligase CBL-C. (437 aa)
CBLE3 ubiquitin-protein ligase CBL isoform X2. (910 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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