STRINGSTRING
FGF21 FGF21 KLB KLB FGFBP1 FGFBP1 KITLG KITLG FGFR2 FGFR2 ENSUMAP00000005635 ENSUMAP00000005635 FGF2 FGF2 ENSUMAP00000006714 ENSUMAP00000006714 KIT KIT FGF10 FGF10 FGF17 FGF17 ENSUMAP00000009652 ENSUMAP00000009652 FGF19 FGF19 FGF5 FGF5 FGFR1 FGFR1 FGF1 FGF1 FGF7 FGF7 FGF6 FGF6 FGF9 FGF9 FGF20 FGF20 FGFR4 FGFR4 FGF18 FGF18
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
KLBKlotho beta. (1023 aa)
FGFBP1Fibroblast growth factor-binding protein 1. (255 aa)
KITLGKit ligand. (274 aa)
FGFR2Fibroblast growth factor receptor. (602 aa)
ENSUMAP00000005635annotation not available (292 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
ENSUMAP00000006714annotation not available (171 aa)
KITMast/stem cell growth factor receptor Kit; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
ENSUMAP00000009652annotation not available (108 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (270 aa)
FGFR1Fibroblast growth factor receptor. (788 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
FGFR4Fibroblast growth factor receptor. (795 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.