STRINGSTRING
PEA15 PEA15 PPP1R3C PPP1R3C PKN2 PKN2 CREB5 CREB5 DUSP16 DUSP16 DUSP6 DUSP6 CREBBP CREBBP PPP1R15B PPP1R15B ROCK2 ROCK2 MAPK4 MAPK4 MAPK1 MAPK1 SIK3 SIK3 EPM2A EPM2A TRPC3 TRPC3 PKN1 PKN1 PTPN7 PTPN7 LOC103657720 LOC103657720 PPP1R12A PPP1R12A MAP2K3 MAP2K3 LRRC56 LRRC56 MYL5 MYL5 DUSP8 DUSP8 ENSUMAP00000008134 ENSUMAP00000008134 MAPK7 MAPK7 RPS6KA5 RPS6KA5 ENSUMAP00000008518 ENSUMAP00000008518 PRKD1 PRKD1 PPP1R3A PPP1R3A CREB3 CREB3 SIK2 SIK2 PPP1CC PPP1CC MAP2K6 MAP2K6 FOS FOS MAPKAPK5 MAPKAPK5 ATF1 ATF1 PPP1R3B PPP1R3B MAP3K1 MAP3K1 CRTC3 CRTC3 EEF2K EEF2K MAPK13 MAPK13 MAPK14 MAPK14 ATF7 ATF7 RPS6KA3 RPS6KA3 FOSL1 FOSL1 MAPK3 MAPK3 PRKCG PRKCG RPS6KA2 RPS6KA2 MAP2K1 MAP2K1 DUSP2 DUSP2 PPP1CA PPP1CA RPS6KA1 RPS6KA1 HSPB1 HSPB1 ENSUMAP00000017922 ENSUMAP00000017922 STYX STYX PRKD3 PRKD3 MRAS MRAS CREB3L1 CREB3L1 ATF2 ATF2 MAPK8 MAPK8 CREB3L2 CREB3L2 CREM CREM PTPN3 PTPN3 PPP1R1B PPP1R1B PPP1R14A PPP1R14A MAPK12 MAPK12 NFAT5 NFAT5 LRRD1 LRRD1 MAPK6 MAPK6 ROCK1 ROCK1 PPP1CB PPP1CB FOSL2 FOSL2 CREB3L4 CREB3L4 CRTC2 CRTC2 HSPB6 HSPB6 SCGN SCGN PKN3 PKN3 PTPRR PTPRR PRKCA PRKCA MAP2K4 MAP2K4 MAPKAPK3 MAPKAPK3 MARK1 MARK1 DUSP10 DUSP10 CREB1 CREB1 RHOA RHOA FOSB FOSB MAP3K5 MAP3K5 CREBRF CREBRF DUSP1 DUSP1 MAPK9 MAPK9 MAPK10 MAPK10 MAPKAPK2 MAPKAPK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PEA15Astrocytic phosphoprotein PEA-15. (130 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
PKN2Serine/threonine-protein kinase N2. (944 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
DUSP16LOW QUALITY PROTEIN: dual specificity protein phosphatase 16. (758 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (316 aa)
CREBBPCREB-binding protein. (1954 aa)
PPP1R15BLOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 15B. (660 aa)
ROCK2Rho-associated protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1360 aa)
MAPK4Mitogen-activated protein kinase 4; Belongs to the protein kinase superfamily. (449 aa)
MAPK1Mitogen-activated protein kinase. (363 aa)
SIK3Serine/threonine-protein kinase SIK3. (1276 aa)
EPM2ALaforin. (193 aa)
TRPC3Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (848 aa)
PKN1Serine/threonine-protein kinase N1. (913 aa)
PTPN7Tyrosine-protein phosphatase non-receptor type 7 isoform X1. (360 aa)
LOC103657720Protein phosphatase 1 regulatory subunit. (179 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (942 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
LRRC56Leucine-rich repeat-containing protein 56 isoform X3. (545 aa)
MYL5Myosin light chain 5. (172 aa)
DUSP8Dual specificity protein phosphatase 8 isoform X1. (333 aa)
ENSUMAP00000008134annotation not available (95 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (264 aa)
RPS6KA5Ribosomal protein S6 kinase. (853 aa)
ENSUMAP00000008518annotation not available (76 aa)
PRKD1Serine/threonine-protein kinase D1. (874 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1122 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (358 aa)
SIK2Serine/threonine-protein kinase SIK2. (825 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (329 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MAPKAPK5MAP kinase-activated protein kinase 5 isoform X2. (471 aa)
ATF1Cyclic AMP-dependent transcription factor ATF-1. (279 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (339 aa)
MAP3K1LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1. (1362 aa)
CRTC3CREB-regulated transcription coactivator 3 isoform X1. (595 aa)
EEF2KEukaryotic elongation factor 2 kinase. (725 aa)
MAPK13Mitogen-activated protein kinase. (373 aa)
MAPK14Mitogen-activated protein kinase. (362 aa)
ATF7Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (483 aa)
RPS6KA3Ribosomal protein S6 kinase. (718 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (654 aa)
RPS6KA2Ribosomal protein S6 kinase. (733 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
DUSP2Dual specificity protein phosphatase 2. (211 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (319 aa)
RPS6KA1Ribosomal protein S6 kinase. (719 aa)
HSPB1Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family. (290 aa)
ENSUMAP00000017922annotation not available (78 aa)
STYXSerine/threonine/tyrosine-interacting protein isoform X1. (223 aa)
PRKD3Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (890 aa)
MRASRas-related protein M-Ras. (297 aa)
CREB3L1LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 1. (501 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (482 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
CREMcAMP-responsive element modulator isoform X3. (332 aa)
PTPN3Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (919 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (169 aa)
PPP1R14AProtein phosphatase 1 regulatory subunit 14A. (74 aa)
MAPK12Mitogen-activated protein kinase. (260 aa)
NFAT5Nuclear factor of activated T-cells 5. (1527 aa)
LRRD1Leucine-rich repeat and death domain-containing protein 1. (869 aa)
MAPK6Mitogen-activated protein kinase 6. (722 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1355 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (304 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (301 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4. (393 aa)
CRTC2CREB-regulated transcription coactivator 2 isoform X1. (627 aa)
HSPB6LOW QUALITY PROTEIN: heat shock protein beta-6; Belongs to the small heat shock protein (HSP20) family. (150 aa)
SCGNSecretagogin. (119 aa)
PKN3Serine/threonine-protein kinase N3. (723 aa)
PTPRRReceptor-type tyrosine-protein phosphatase R isoform X1. (652 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (411 aa)
MAPKAPK3MAP kinase-activated protein kinase 3 isoform X1; Belongs to the protein kinase superfamily. (384 aa)
MARK1Non-specific serine/threonine protein kinase. (783 aa)
DUSP10Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
RHOARas homolog family member A. (193 aa)
FOSBProtein fosB. (237 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1768 aa)
CREBRFCREB3 regulatory factor isoform X2. (631 aa)
DUSP1Dual specificity protein phosphatase 1; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (225 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAPK10Mitogen-activated protein kinase. (460 aa)
MAPKAPK2MAP kinase-activated protein kinase 2. (349 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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