(17 nodes) Mixed, incl. MAP kinase kinase activity, and JUN kinase activity network (Ursus maritimus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DUSP16	LOW QUALITY PROTEIN: dual specificity protein phosphatase 16. (758 aa)
	DUSP6	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (316 aa)
	MAPK1	Mitogen-activated protein kinase. (363 aa)
	PTPN7	Tyrosine-protein phosphatase non-receptor type 7 isoform X1. (360 aa)
	MAP2K3	Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
	MAP2K6	Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
	MAP3K1	LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1. (1362 aa)
	MAPK3	Mitogen-activated protein kinase. (354 aa)
	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	DUSP2	Dual specificity protein phosphatase 2. (211 aa)
	MAPK8	Mitogen-activated protein kinase. (384 aa)
	PTPRR	Receptor-type tyrosine-protein phosphatase R isoform X1. (652 aa)
	MAP2K4	Dual specificity mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (411 aa)
	MAP3K5	Mitogen-activated protein kinase kinase kinase 5. (1768 aa)
	DUSP1	Dual specificity protein phosphatase 1; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (225 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	MAPK10	Mitogen-activated protein kinase. (460 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DUSP1	MAPK1	ENSUMAP00000034054	ENSUMAP00000004216	Dual specificity protein phosphatase 1; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase.	0.954
DUSP1	MAPK10	ENSUMAP00000034054	ENSUMAP00000034624	Dual specificity protein phosphatase 1; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase.	0.947
DUSP1	MAPK3	ENSUMAP00000034054	ENSUMAP00000014967	Dual specificity protein phosphatase 1; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase.	0.945
DUSP1	MAPK8	ENSUMAP00000034054	ENSUMAP00000021351	Dual specificity protein phosphatase 1; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase.	0.947
DUSP1	MAPK9	ENSUMAP00000034054	ENSUMAP00000034148	Dual specificity protein phosphatase 1; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase.	0.947
DUSP16	MAP3K5	ENSUMAP00000002630	ENSUMAP00000033317	LOW QUALITY PROTEIN: dual specificity protein phosphatase 16.	Mitogen-activated protein kinase kinase kinase 5.	0.604
DUSP16	MAPK1	ENSUMAP00000002630	ENSUMAP00000004216	LOW QUALITY PROTEIN: dual specificity protein phosphatase 16.	Mitogen-activated protein kinase.	0.949
DUSP16	MAPK10	ENSUMAP00000002630	ENSUMAP00000034624	LOW QUALITY PROTEIN: dual specificity protein phosphatase 16.	Mitogen-activated protein kinase.	0.932
DUSP16	MAPK3	ENSUMAP00000002630	ENSUMAP00000014967	LOW QUALITY PROTEIN: dual specificity protein phosphatase 16.	Mitogen-activated protein kinase.	0.949
DUSP16	MAPK8	ENSUMAP00000002630	ENSUMAP00000021351	LOW QUALITY PROTEIN: dual specificity protein phosphatase 16.	Mitogen-activated protein kinase.	0.932
DUSP16	MAPK9	ENSUMAP00000002630	ENSUMAP00000034148	LOW QUALITY PROTEIN: dual specificity protein phosphatase 16.	Mitogen-activated protein kinase.	0.850
DUSP2	MAPK1	ENSUMAP00000016688	ENSUMAP00000004216	Dual specificity protein phosphatase 2.	Mitogen-activated protein kinase.	0.954
DUSP2	MAPK10	ENSUMAP00000016688	ENSUMAP00000034624	Dual specificity protein phosphatase 2.	Mitogen-activated protein kinase.	0.815
DUSP2	MAPK3	ENSUMAP00000016688	ENSUMAP00000014967	Dual specificity protein phosphatase 2.	Mitogen-activated protein kinase.	0.945
DUSP2	MAPK8	ENSUMAP00000016688	ENSUMAP00000021351	Dual specificity protein phosphatase 2.	Mitogen-activated protein kinase.	0.815
DUSP2	MAPK9	ENSUMAP00000016688	ENSUMAP00000034148	Dual specificity protein phosphatase 2.	Mitogen-activated protein kinase.	0.814
DUSP6	MAPK1	ENSUMAP00000002751	ENSUMAP00000004216	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase.	0.969
DUSP6	MAPK3	ENSUMAP00000002751	ENSUMAP00000014967	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase.	0.967
MAP2K1	MAP3K1	ENSUMAP00000016615	ENSUMAP00000012203	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.	LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1.	0.958
MAP2K1	MAPK1	ENSUMAP00000016615	ENSUMAP00000004216	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.995