(12 nodes) Mixed, incl. Regulation of localization of FOXO transcription factors, and Cellular response to actinomycin D network (Ursus maritimus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SGK2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (367 aa)
	SIRT1	NAD-dependent protein deacetylase sirtuin-1 isoform X2. (446 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (519 aa)
	SFN	14-3-3 protein sigma; Belongs to the 14-3-3 family. (258 aa)
	SGK3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (490 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
	FOXO1	Forkhead box protein O1. (432 aa)
	FOXO3	Forkhead box protein O3. (453 aa)
	MDM2	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
	FOXO4	Forkhead box protein O4 isoform X1. (505 aa)
	PDPK1	3-phosphoinositide-dependent protein kinase 1 isoform X1. (572 aa)
	SGK1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (431 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT3	FOXO1	ENSUMAP00000016096	ENSUMAP00000026699	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box protein O1.	0.971
AKT3	FOXO3	ENSUMAP00000016096	ENSUMAP00000027234	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box protein O3.	0.972
AKT3	FOXO4	ENSUMAP00000016096	ENSUMAP00000030965	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box protein O4 isoform X1.	0.971
AKT3	MDM2	ENSUMAP00000016096	ENSUMAP00000028570	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.962
AKT3	PDPK1	ENSUMAP00000016096	ENSUMAP00000031700	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	3-phosphoinositide-dependent protein kinase 1 isoform X1.	0.990
AKT3	SGK1	ENSUMAP00000016096	ENSUMAP00000033868	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.550
AKT3	SGK2	ENSUMAP00000016096	ENSUMAP00000001121	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.549
AKT3	SGK3	ENSUMAP00000016096	ENSUMAP00000019559	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.424
AKT3	TP53	ENSUMAP00000016096	ENSUMAP00000023207	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.927
FOXO1	AKT3	ENSUMAP00000026699	ENSUMAP00000016096	Forkhead box protein O1.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.971
FOXO1	FOXO3	ENSUMAP00000026699	ENSUMAP00000027234	Forkhead box protein O1.	Forkhead box protein O3.	0.953
FOXO1	FOXO4	ENSUMAP00000026699	ENSUMAP00000030965	Forkhead box protein O1.	Forkhead box protein O4 isoform X1.	0.951
FOXO1	MDM2	ENSUMAP00000026699	ENSUMAP00000028570	Forkhead box protein O1.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.571
FOXO1	SFN	ENSUMAP00000026699	ENSUMAP00000016188	Forkhead box protein O1.	14-3-3 protein sigma; Belongs to the 14-3-3 family.	0.694
FOXO1	SGK1	ENSUMAP00000026699	ENSUMAP00000033868	Forkhead box protein O1.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.955
FOXO1	SGK2	ENSUMAP00000026699	ENSUMAP00000001121	Forkhead box protein O1.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.927
FOXO1	SGK3	ENSUMAP00000026699	ENSUMAP00000019559	Forkhead box protein O1.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.914
FOXO1	SIRT1	ENSUMAP00000026699	ENSUMAP00000009446	Forkhead box protein O1.	NAD-dependent protein deacetylase sirtuin-1 isoform X2.	0.994
FOXO1	TP53	ENSUMAP00000026699	ENSUMAP00000023207	Forkhead box protein O1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.773
FOXO3	AKT3	ENSUMAP00000027234	ENSUMAP00000016096	Forkhead box protein O3.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.972