STRINGSTRING
DACT1 DACT1 DKK2 DKK2 VANGL2 VANGL2 LEF1 LEF1 GLIS3-2 GLIS3-2 WNT3A WNT3A WNT9A WNT9A BCL9L BCL9L TNKS2 TNKS2 RNF146 RNF146 TG TG LOC103682075 LOC103682075 CDON CDON LRP6 LRP6 GSK3A GSK3A WNT2 WNT2 WNT16 WNT16 CTNNB1 CTNNB1 ENSUMAP00000005627 ENSUMAP00000005627 KIF27 KIF27 DAAM2 DAAM2 CSNK1A1 CSNK1A1 CTBP2 CTBP2 NKD1 NKD1 SPOPL SPOPL DVL3 DVL3 ENSUMAP00000007957 ENSUMAP00000007957 ENSUMAP00000008309 ENSUMAP00000008309 TCF7L1 TCF7L1 WNT10B WNT10B WNT1 WNT1 DHH DHH WLS WLS KIF7 KIF7 SMO SMO IQCE IQCE PORCN PORCN ROR1 ROR1 EFCAB7 EFCAB7 TNKS TNKS PTCH1 PTCH1 LRPAP1 LRPAP1 SLC5A5 SLC5A5 GLI3 GLI3 TLE3 TLE3 BCL9 BCL9 DKK1 DKK1 VANGL1 VANGL1 CUL1 CUL1 FAM131B FAM131B WNT5B WNT5B PRICKLE4 PRICKLE4 GPC4 GPC4 NLK NLK CUBN CUBN INVS INVS LRP2BP LRP2BP LDLRAP1 LDLRAP1 GLI2 GLI2 LOC103661308 LOC103661308 SCUBE2 SCUBE2 WNT4 WNT4 ENSUMAP00000018664 ENSUMAP00000018664 LRP2 LRP2 WNT2B WNT2B DAAM1 DAAM1 LRP5 LRP5 SHH SHH CBY1 CBY1 CD320 CD320 DVL2 DVL2 TNFRSF19 TNFRSF19 HHIP HHIP RYK RYK WNT3 WNT3 ENSUMAP00000021166 ENSUMAP00000021166 KIAA1549 KIAA1549 SPOP SPOP WNT7A WNT7A BAMBI BAMBI KREMEN1 KREMEN1 FBXW7 FBXW7 DKK3 DKK3 SFRP2 SFRP2 WNT8A WNT8A TCN2 TCN2 DISP1 DISP1 ROR2 ROR2 APC APC FRZB FRZB CER1 CER1 TCF7 TCF7 APCDD1 APCDD1 FZD1 FZD1 CBLIF CBLIF TCN1 TCN1 IHH IHH WNT10A WNT10A VLDLR VLDLR RELN RELN STK36 STK36 FZD6 FZD6 GLI1 GLI1 WNT5A WNT5A FZD10 FZD10 WIF1 WIF1 HECW2 HECW2 AXIN1 AXIN1 AMER1 AMER1 HHAT HHAT AXIN2 AXIN2 LDLR LDLR FZD7 FZD7 CTNND2 CTNND2 DAB1 DAB1 GLIS1 GLIS1 LRP8 LRP8 FZD3 FZD3 JUP JUP BTRC BTRC EVC EVC EVC2 EVC2 TLE4 TLE4 SUFU SUFU TLE1 TLE1 FZD4 FZD4 PRICKLE1 PRICKLE1 PTCH2 PTCH2 TCF7L2 TCF7L2 RNF130 RNF130 FBXW11 FBXW11 TTC23 TTC23 GSK3B GSK3B DKK4 DKK4 SFRP1 SFRP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DACT1Dishevelled binding antagonist of beta catenin 1. (755 aa)
DKK2Dickkopf WNT signaling pathway inhibitor 2. (259 aa)
VANGL2Vang-like protein. (531 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X2. (450 aa)
GLIS3-2Zinc finger protein GLIS1/3. (68 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (328 aa)
BCL9LLOW QUALITY PROTEIN: B-cell CLL/lymphoma 9-like protein. (1497 aa)
TNKS2Poly [ADP-ribose] polymerase. (1155 aa)
RNF146E3 ubiquitin-protein ligase RNF146. (360 aa)
TGLOW QUALITY PROTEIN: thyroglobulin. (896 aa)
LOC103682075Segment polarity protein dishevelled homolog DVL-1-like. (893 aa)
CDONCell adhesion molecule-related/down-regulated by oncogenes isoform X1. (1271 aa)
LRP6Low-density lipoprotein receptor-related protein 6 isoform X1. (1462 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (417 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (331 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (343 aa)
CTNNB1Catenin beta-1. (787 aa)
ENSUMAP00000005627annotation not available (172 aa)
KIF27Kinesin-like protein KIF27; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1401 aa)
DAAM2Dishevelled associated activator of morphogenesis 2. (1066 aa)
CSNK1A1Casein kinase I isoform alpha isoform X1; Belongs to the protein kinase superfamily. (380 aa)
CTBP2LOW QUALITY PROTEIN: C-terminal-binding protein 2. (470 aa)
NKD1Protein naked cuticle homolog 1. (446 aa)
SPOPLSpeckle type BTB/POZ protein like. (392 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3. (423 aa)
ENSUMAP00000007957annotation not available (154 aa)
ENSUMAP00000008309annotation not available (73 aa)
TCF7L1Transcription factor 7-like 1. (535 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (334 aa)
DHHDesert hedgehog protein. (372 aa)
WLSWnt ligand secretion mediator. (541 aa)
KIF7LOW QUALITY PROTEIN: kinesin-like protein KIF7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (156 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (745 aa)
IQCEIQ domain-containing protein E. (559 aa)
PORCNProtein-cysteine N-palmitoyltransferase porcupine; Belongs to the membrane-bound acyltransferase family. (393 aa)
ROR1Tyrosine-protein kinase transmembrane receptor ROR1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (983 aa)
EFCAB7EF-hand calcium-binding domain-containing protein 7. (629 aa)
TNKSPoly [ADP-ribose] polymerase. (1333 aa)
PTCH1Protein patched homolog 1. (1388 aa)
LRPAP1LDL receptor related protein associated protein 1. (332 aa)
SLC5A5Sodium/iodide cotransporter; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (640 aa)
GLI3Transcriptional activator GLI3. (524 aa)
TLE3Transducin-like enhancer protein 3. (762 aa)
BCL9B-cell CLL/lymphoma 9 protein isoform X3. (1352 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (270 aa)
VANGL1Vang-like protein. (524 aa)
CUL1Cullin-1; Belongs to the cullin family. (776 aa)
FAM131BProtein FAM131B isoform X2. (341 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (107 aa)
PRICKLE4Prickle-like protein 4. (199 aa)
GPC4LOW QUALITY PROTEIN: glypican-4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (452 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (515 aa)
CUBNCubilin. (3624 aa)
INVSInversin isoform X1. (1076 aa)
LRP2BPLRP2-binding protein. (348 aa)
LDLRAP1Low density lipoprotein receptor adapter protein 1. (296 aa)
GLI2Zinc finger protein GLI2. (708 aa)
LOC103661308Transcobalamin-1-like. (431 aa)
SCUBE2Signal peptide, CUB and EGF-like domain-containing protein 2. (469 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
ENSUMAP00000018664annotation not available (401 aa)
LRP2Low-density lipoprotein receptor-related protein 2. (403 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (299 aa)
DAAM1Disheveled-associated activator of morphogenesis 1. (255 aa)
LRP5Low-density lipoprotein receptor-related protein 5. (1602 aa)
SHHSonic hedgehog protein. (168 aa)
CBY1Chibby family member 1, beta catenin antagonist. (132 aa)
CD320CD320 antigen. (347 aa)
DVL2LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2. (391 aa)
TNFRSF19Tumor necrosis factor receptor superfamily member 19-like isoform X3. (342 aa)
HHIPHedgehog-interacting protein isoform X1. (700 aa)
RYKTyrosine-protein kinase RYK. (572 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (175 aa)
ENSUMAP00000021166annotation not available (156 aa)
KIAA1549UPF0606 protein KIAA1549 homolog. (208 aa)
SPOPSpeckle type BTB/POZ protein. (374 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog. (218 aa)
KREMEN1Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (473 aa)
FBXW7F-box/WD repeat-containing protein 7 isoform X1. (706 aa)
DKK3Dickkopf-related protein 3. (277 aa)
SFRP2Secreted frizzled-related protein 2. (299 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (326 aa)
TCN2Transcobalamin-2. (430 aa)
DISP1Protein dispatched homolog 1 isoform X1. (1545 aa)
ROR2LOW QUALITY PROTEIN: tyrosine-protein kinase transmembrane receptor ROR2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (889 aa)
APCLOW QUALITY PROTEIN: adenomatous polyposis coli protein. (2824 aa)
FRZBSecreted frizzled-related protein 3. (325 aa)
CER1Cerberus 1, DAN family BMP antagonist. (271 aa)
TCF7Transcription factor 7 isoform X4. (316 aa)
APCDD1Protein APCDD1. (505 aa)
FZD1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (560 aa)
CBLIFGastric intrinsic factor isoform X1. (442 aa)
TCN1Transcobalamin-1. (434 aa)
IHHIndian hedgehog protein. (145 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (270 aa)
VLDLRVery low-density lipoprotein receptor. (881 aa)
RELNLOW QUALITY PROTEIN: reelin. (3457 aa)
STK36Serine/threonine-protein kinase 36. (1190 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
GLI1Zinc finger protein GLI1. (1097 aa)
WNT5AWingless-type MMTV integration site family, member 5. (123 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (398 aa)
WIF1Wnt inhibitory factor 1. (393 aa)
HECW2HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2. (1571 aa)
AXIN1Axin-1 isoform X2. (867 aa)
AMER1LOW QUALITY PROTEIN: APC membrane recruitment protein 1. (1098 aa)
HHATProtein-cysteine N-palmitoyltransferase HHAT; Belongs to the membrane-bound acyltransferase family. (493 aa)
AXIN2Axin-2. (764 aa)
LDLRLow-density lipoprotein receptor. (927 aa)
FZD7LOW QUALITY PROTEIN: frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (541 aa)
CTNND2Catenin delta-2. (328 aa)
DAB1DAB adaptor protein 1. (565 aa)
GLIS1Zinc finger protein GLIS1. (655 aa)
LRP8LDL receptor related protein 8. (925 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
JUPJunction plakoglobin. (716 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
EVCEllis-van Creveld syndrome protein. (980 aa)
EVC2LOW QUALITY PROTEIN: limbin. (1188 aa)
TLE4TLE family member 4, transcriptional corepressor. (712 aa)
SUFUSuppressor of fused homolog. (489 aa)
TLE1Transducin-like enhancer protein 1. (714 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (534 aa)
PRICKLE1Prickle-like protein 1. (804 aa)
PTCH2LOW QUALITY PROTEIN: protein patched homolog 2. (1189 aa)
TCF7L2Transcription factor 7-like 2. (587 aa)
RNF130E3 ubiquitin-protein ligase RNF130. (378 aa)
FBXW11F-box/WD repeat-containing protein 11 isoform X1. (510 aa)
TTC23Tetratricopeptide repeat protein 23. (446 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
DKK4Dickkopf WNT signaling pathway inhibitor 4. (221 aa)
SFRP1Secreted frizzled-related protein 1. (305 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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