(19 nodes) I-SMAD binding, and Type III transforming growth factor beta receptor binding network (Ursus maritimus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	SMAD2	Mothers against decapentaplegic homolog. (449 aa)
	LOC103665211	Mothers against decapentaplegic homolog. (244 aa)
	ZFYVE16	Zinc finger FYVE domain-containing protein 16. (1540 aa)
	SMAD4	Mothers against decapentaplegic homolog. (546 aa)
	LOC103677394	Transforming growth factor beta-1. (299 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	SMURF1	E3 ubiquitin-protein ligase. (749 aa)
	SKI	Ski oncogene. (681 aa)
	SKIL	Ski-like protein isoform X2. (664 aa)
	SMAD3	Mothers against decapentaplegic homolog. (280 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
	LTBP1	Latent-transforming growth factor beta-binding protein 1 isoform X2. (1393 aa)
	SMAD1	Mothers against decapentaplegic homolog. (465 aa)
	SMAD5	Mothers against decapentaplegic homolog. (465 aa)
	SMURF2	E3 ubiquitin-protein ligase. (739 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
	ZFYVE9	Zinc finger FYVE domain-containing protein. (1421 aa)
	SMAD9	Mothers against decapentaplegic homolog. (445 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103665211	LOC103677394	ENSUMAP00000003199	ENSUMAP00000007299	Mothers against decapentaplegic homolog.	Transforming growth factor beta-1.	0.894
LOC103665211	LTBP1	ENSUMAP00000003199	ENSUMAP00000021312	Mothers against decapentaplegic homolog.	Latent-transforming growth factor beta-binding protein 1 isoform X2.	0.517
LOC103665211	SKI	ENSUMAP00000003199	ENSUMAP00000014124	Mothers against decapentaplegic homolog.	Ski oncogene.	0.447
LOC103665211	SKIL	ENSUMAP00000003199	ENSUMAP00000014251	Mothers against decapentaplegic homolog.	Ski-like protein isoform X2.	0.622
LOC103665211	SMAD1	ENSUMAP00000003199	ENSUMAP00000021317	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.953
LOC103665211	SMAD2	ENSUMAP00000003199	ENSUMAP00000003150	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.966
LOC103665211	SMAD3	ENSUMAP00000003199	ENSUMAP00000016415	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.553
LOC103665211	SMAD4	ENSUMAP00000003199	ENSUMAP00000003792	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.738
LOC103665211	SMAD5	ENSUMAP00000003199	ENSUMAP00000022929	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.980
LOC103665211	SMAD9	ENSUMAP00000003199	ENSUMAP00000033333	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.738
LOC103665211	SMURF1	ENSUMAP00000003199	ENSUMAP00000012693	Mothers against decapentaplegic homolog.	E3 ubiquitin-protein ligase.	0.991
LOC103665211	SMURF2	ENSUMAP00000003199	ENSUMAP00000024541	Mothers against decapentaplegic homolog.	E3 ubiquitin-protein ligase.	0.999
LOC103665211	TGFB2	ENSUMAP00000003199	ENSUMAP00000028351	Mothers against decapentaplegic homolog.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.615
LOC103665211	TGFB3	ENSUMAP00000003199	ENSUMAP00000010030	Mothers against decapentaplegic homolog.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.428
LOC103665211	TGFBR1	ENSUMAP00000003199	ENSUMAP00000017192	Mothers against decapentaplegic homolog.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.999
LOC103665211	TGFBR2	ENSUMAP00000003199	ENSUMAP00000000134	Mothers against decapentaplegic homolog.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.984
LOC103665211	ZFYVE16	ENSUMAP00000003199	ENSUMAP00000003460	Mothers against decapentaplegic homolog.	Zinc finger FYVE domain-containing protein 16.	0.618
LOC103665211	ZFYVE9	ENSUMAP00000003199	ENSUMAP00000031540	Mothers against decapentaplegic homolog.	Zinc finger FYVE domain-containing protein.	0.565
LOC103677394	LOC103665211	ENSUMAP00000007299	ENSUMAP00000003199	Transforming growth factor beta-1.	Mothers against decapentaplegic homolog.	0.894
LOC103677394	LTBP1	ENSUMAP00000007299	ENSUMAP00000021312	Transforming growth factor beta-1.	Latent-transforming growth factor beta-binding protein 1 isoform X2.	0.996