61 items (Ursus maritimus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CYCS	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	TAB2	LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (670 aa)
	CRADD	CASP2 and RIPK1 domain containing adaptor with death domain. (250 aa)
	TNIP1	TNFAIP3-interacting protein 1 isoform X1. (639 aa)
	TRAF1	TNF receptor-associated factor. (408 aa)
	IKBKE	LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit epsilon. (692 aa)
	MAVS	LOW QUALITY PROTEIN: mitochondrial antiviral-signaling protein. (710 aa)
	NFKB1	Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
	NFKBIE	NF-kappa-B inhibitor epsilon. (357 aa)
	DIABLO	Diablo homolog, mitochondrial. (270 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1252 aa)
	PIDD1	LOW QUALITY PROTEIN: p53-induced death domain-containing protein 1. (844 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
	TNIP2	TNFAIP3 interacting protein 2. (329 aa)
	LOC103671065	Uncharacterized protein LOC103671065 isoform X3. (435 aa)
	FADD	FAS-associated death domain protein. (192 aa)
	LTBR	Tumor necrosis factor receptor superfamily member 3 isoform X2. (421 aa)
	TNFRSF1A	LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A. (507 aa)
	PLEKHG6	Pleckstrin homology domain-containing family G member 6. (788 aa)
	TNFSF10	Tumor necrosis factor ligand superfamily member 10; Belongs to the tumor necrosis factor family. (286 aa)
	BIRC2	Baculoviral IAP repeat-containing protein 2. (619 aa)
	BIRC3	Baculoviral IAP repeat-containing protein 3-like. (516 aa)
	RELA	Transcription factor p65. (585 aa)
	NFKBIA	NF-kappa-B inhibitor alpha. (253 aa)
	TRAF4	TNF receptor-associated factor. (435 aa)
	CASP2	Caspase-2 isoform X1; Belongs to the peptidase C14A family. (452 aa)
	FAS	Tumor necrosis factor receptor superfamily member 6 isoform X1. (351 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
	CASP3	Caspase-3 isoform X1; Belongs to the peptidase C14A family. (302 aa)
	TAB1	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1. (498 aa)
	TAB3	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3. (664 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	LTA	Lymphotoxin-alpha; Belongs to the tumor necrosis factor family. (204 aa)
	MAP3K14	Mitogen-activated protein kinase kinase kinase 14. (873 aa)
	MAP3K8	Mitogen-activated protein kinase kinase kinase 8. (467 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
	RIPK1	Receptor-interacting serine/threonine-protein kinase 1. (665 aa)
	REL	Proto-oncogene c-Rel isoform X1. (604 aa)
	NFKBIB	LOW QUALITY PROTEIN: NF-kappa-B inhibitor beta. (360 aa)
	BIRC6	Baculoviral IAP repeat-containing protein 6. (4808 aa)
	IKBKG	NF-kappa-B essential modulator. (291 aa)
	FASLG	Tumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (269 aa)
	TRADD	Tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2. (314 aa)
	TRAF5	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (582 aa)
	CFLAR	CASP8 and FADD-like apoptosis regulator isoform X2; Belongs to the peptidase C14A family. (482 aa)
	CASP10	Caspase-10 isoform X1; Belongs to the peptidase C14A family. (481 aa)
	CASP8	Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
	CASP9	Caspase-9 isoform X1; Belongs to the peptidase C14A family. (413 aa)
	TNFRSF1B	LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1B. (313 aa)
	CHUK	Inhibitor of nuclear factor kappa-B kinase subunit alpha. (680 aa)
	RIPK3	Receptor-interacting serine/threonine-protein kinase 3; Belongs to the protein kinase superfamily. (487 aa)
	BCL3	B-cell lymphoma 3 protein. (355 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (494 aa)
	RELB	Transcription factor RelB. (482 aa)
	NFKB2	Nuclear factor NF-kappa-B p100 subunit. (925 aa)
	TNFAIP3	Tumor necrosis factor alpha-induced protein 3. (714 aa)
	SQSTM1	Sequestosome-1. (391 aa)
	CASP7	Caspase-7; Belongs to the peptidase C14A family. (301 aa)
	XIAP	E3 ubiquitin-protein ligase XIAP. (497 aa)
	ENSUMAP00000034969	annotation not available (120 aa)
	IKBKB	Inhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	BIRC2	ENSUMAP00000007241	ENSUMAP00000012471	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat-containing protein 2.	0.661
APAF1	BIRC3	ENSUMAP00000007241	ENSUMAP00000012474	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat-containing protein 3-like.	0.661
APAF1	BIRC6	ENSUMAP00000007241	ENSUMAP00000026415	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat-containing protein 6.	0.875
APAF1	CASP10	ENSUMAP00000007241	ENSUMAP00000029779	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase-10 isoform X1; Belongs to the peptidase C14A family.	0.780
APAF1	CASP2	ENSUMAP00000007241	ENSUMAP00000016144	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase-2 isoform X1; Belongs to the peptidase C14A family.	0.879
APAF1	CASP3	ENSUMAP00000007241	ENSUMAP00000018732	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase-3 isoform X1; Belongs to the peptidase C14A family.	0.994
APAF1	CASP7	ENSUMAP00000007241	ENSUMAP00000033891	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase-7; Belongs to the peptidase C14A family.	0.878
APAF1	CASP8	ENSUMAP00000007241	ENSUMAP00000029788	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase-8 isoform X1; Belongs to the peptidase C14A family.	0.926
APAF1	CASP9	ENSUMAP00000007241	ENSUMAP00000030022	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase-9 isoform X1; Belongs to the peptidase C14A family.	0.999
APAF1	CFLAR	ENSUMAP00000007241	ENSUMAP00000029777	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	CASP8 and FADD-like apoptosis regulator isoform X2; Belongs to the peptidase C14A family.	0.735
APAF1	CYCS	ENSUMAP00000007241	ENSUMAP00000001665	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.999
APAF1	DIABLO	ENSUMAP00000007241	ENSUMAP00000006863	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Diablo homolog, mitochondrial.	0.770
APAF1	FADD	ENSUMAP00000007241	ENSUMAP00000009429	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	FAS-associated death domain protein.	0.664
APAF1	FAS	ENSUMAP00000007241	ENSUMAP00000016893	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Tumor necrosis factor receptor superfamily member 6 isoform X1.	0.512
APAF1	FASLG	ENSUMAP00000007241	ENSUMAP00000027494	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Tumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family.	0.624
APAF1	TNF	ENSUMAP00000007241	ENSUMAP00000020603	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.446
APAF1	TRADD	ENSUMAP00000007241	ENSUMAP00000027876	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2.	0.455
APAF1	XIAP	ENSUMAP00000007241	ENSUMAP00000034003	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	E3 ubiquitin-protein ligase XIAP.	0.850
BCL3	CHUK	ENSUMAP00000032162	ENSUMAP00000031552	B-cell lymphoma 3 protein.	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	0.516
BCL3	IKBKB	ENSUMAP00000032162	ENSUMAP00000035567	B-cell lymphoma 3 protein.	Inhibitor of nuclear factor kappa-B kinase subunit beta.	0.533