(21 nodes) Mixed, incl. Notch signaling pathway, and N-box binding network (Ursus maritimus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HES1	Transcription factor HES-1. (166 aa)
	NOTCH3	Neurogenic locus notch homolog protein 3; Belongs to the G-protein coupled receptor 1 family. (2136 aa)
	RBPJ	Recombination signal binding protein for immunoglobulin kappa J region. (491 aa)
	LOC103671078	mucin-5AC-like. (1013 aa)
	NEUROG3	Neurogenin-3. (215 aa)
	MAML2	Mastermind-like protein 2 isoform X1. (924 aa)
	ENSUMAP00000010745	annotation not available (178 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1220 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (695 aa)
	DTX1	E3 ubiquitin-protein ligase DTX1. (259 aa)
	FHL1	Four and a half LIM domains protein 1. (177 aa)
	EYS	LOW QUALITY PROTEIN: protein eyes shut homolog. (290 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (701 aa)
	HEY1	Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
	MFNG	Beta-1,3-N-acetylglucosaminyltransferase. (413 aa)
	HEYL	Hairy/enhancer-of-split related with YRPW motif-like protein isoform X1. (305 aa)
	CARMIL3	LOW QUALITY PROTEIN: leucine-rich repeat-containing protein 16B. (1331 aa)
	HES3	Transcription factor HES-3. (179 aa)
	MAML1	LOW QUALITY PROTEIN: mastermind-like protein 1. (789 aa)
	RBPJL	Recombining binding protein suppressor of hairless-like protein. (527 aa)
	NOTCH2	Neurogenic locus notch homolog protein 2. (2444 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CARMIL3	RBPJ	ENSUMAP00000031347	ENSUMAP00000005257	LOW QUALITY PROTEIN: leucine-rich repeat-containing protein 16B.	Recombination signal binding protein for immunoglobulin kappa J region.	0.418
CARMIL3	RBPJL	ENSUMAP00000031347	ENSUMAP00000035204	LOW QUALITY PROTEIN: leucine-rich repeat-containing protein 16B.	Recombining binding protein suppressor of hairless-like protein.	0.418
DLL1	DLL4	ENSUMAP00000011417	ENSUMAP00000016887	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.936
DLL1	DTX1	ENSUMAP00000011417	ENSUMAP00000013795	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	E3 ubiquitin-protein ligase DTX1.	0.522
DLL1	EYS	ENSUMAP00000011417	ENSUMAP00000014791	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	LOW QUALITY PROTEIN: protein eyes shut homolog.	0.641
DLL1	HES1	ENSUMAP00000011417	ENSUMAP00000000894	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Transcription factor HES-1.	0.566
DLL1	HEY1	ENSUMAP00000011417	ENSUMAP00000020372	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hes related family bHLH transcription factor with YRPW motif 1.	0.476
DLL1	HEYL	ENSUMAP00000011417	ENSUMAP00000026815	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hairy/enhancer-of-split related with YRPW motif-like protein isoform X1.	0.476
DLL1	JAG1	ENSUMAP00000011417	ENSUMAP00000011268	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.462
DLL1	MAML1	ENSUMAP00000011417	ENSUMAP00000033628	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	LOW QUALITY PROTEIN: mastermind-like protein 1.	0.660
DLL1	MAML2	ENSUMAP00000011417	ENSUMAP00000010735	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind-like protein 2 isoform X1.	0.648
DLL1	MFNG	ENSUMAP00000011417	ENSUMAP00000021352	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Beta-1,3-N-acetylglucosaminyltransferase.	0.569
DLL1	NOTCH2	ENSUMAP00000011417	ENSUMAP00000035653	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch homolog protein 2.	0.988
DLL1	NOTCH3	ENSUMAP00000011417	ENSUMAP00000004362	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch homolog protein 3; Belongs to the G-protein coupled receptor 1 family.	0.921
DLL1	RBPJ	ENSUMAP00000011417	ENSUMAP00000005257	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombination signal binding protein for immunoglobulin kappa J region.	0.762
DLL1	RBPJL	ENSUMAP00000011417	ENSUMAP00000035204	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombining binding protein suppressor of hairless-like protein.	0.460
DLL4	DLL1	ENSUMAP00000016887	ENSUMAP00000011417	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.936
DLL4	EYS	ENSUMAP00000016887	ENSUMAP00000014791	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	LOW QUALITY PROTEIN: protein eyes shut homolog.	0.585
DLL4	HES1	ENSUMAP00000016887	ENSUMAP00000000894	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Transcription factor HES-1.	0.565
DLL4	HEY1	ENSUMAP00000016887	ENSUMAP00000020372	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hes related family bHLH transcription factor with YRPW motif 1.	0.652