(47 nodes) Mixed, incl. Multifunctional anion exchangers, and Phosphate ion transport network (Ursus maritimus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SLC2A9	Solute carrier family 2, facilitated glucose transporter member 9 isoform X2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (527 aa)
	SLC26A6	LOW QUALITY PROTEIN: solute carrier family 26 member 6. (784 aa)
	SLC37A4	Solute carrier family 37 member 4. (429 aa)
	SLC37A2	Sugar phosphate exchanger 2. (542 aa)
	PNLIPRP2	Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (464 aa)
	SASH1	SAM and SH3 domain-containing protein 1 isoform X1. (1239 aa)
	CFTR	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1475 aa)
	SLC26A9	Solute carrier family 26 member 9; DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (791 aa)
	CLCN2	Chloride channel protein. (859 aa)
	SLC13A1	Solute carrier family 13 member 1. (153 aa)
	SLC22A13	Solute carrier family 22 member 13 isoform X2. (510 aa)
	SLC26A1	Solute carrier family 26 member 1. (701 aa)
	MYORG	Myogenesis regulating glycosidase (putative); Belongs to the glycosyl hydrolase 31 family. (714 aa)
	SLC47A2	Multidrug and toxin extrusion protein; Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. (544 aa)
	SLC16A9	Monocarboxylate transporter 9 isoform X1. (510 aa)
	ANO1	Anoctamin. (972 aa)
	UMOD	Uromodulin. (639 aa)
	ENSUMAP00000010835	annotation not available (213 aa)
	SLC20A1	Phosphate transporter; Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport. Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. (660 aa)
	HECTD4	Probable E3 ubiquitin-protein ligase HECTD4. (4290 aa)
	PDZK1	Na(+)/H(+) exchange regulatory cofactor NHE-RF3. (536 aa)
	SLC26A8	Testis anion transporter 1. (969 aa)
	LIPK	Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (400 aa)
	SLC5A2	LOW QUALITY PROTEIN: sodium/glucose cotransporter 2; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (656 aa)
	TMPRSS15	Enteropeptidase; Belongs to the peptidase S1 family. (1019 aa)
	SLC26A11	Sodium-independent sulfate anion transporter isoform X2. (673 aa)
	VSTM4	V-set and transmembrane domain-containing protein 4 isoform X1. (351 aa)
	SLC5A4	Low affinity sodium-glucose cotransporter; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (660 aa)
	SLC5A1	Sodium/glucose cotransporter 1 isoform X1; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (633 aa)
	GALNT11	Polypeptide N-acetylgalactosaminyltransferase. (608 aa)
	SLC25A48	Solute carrier family 25 member 48; Belongs to the mitochondrial carrier (TC 2.A.29) family. (250 aa)
	XPR1	Xenotropic and polytropic retrovirus receptor 1. (674 aa)
	GLIS3	Zinc finger protein GLIS3. (918 aa)
	SLC26A3	Chloride anion exchanger; Chloride/bicarbonate exchanger. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (755 aa)
	SLC43A3	Solute carrier family 43 member 3. (618 aa)
	LACTB2	Beta-lactamase-like protein 2. (263 aa)
	SLC31A1	High affinity copper uptake protein 1. (178 aa)
	SLC5A12	Sodium-coupled monocarboxylate transporter 2; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (619 aa)
	SLC26A10	Solute carrier family 26 member 10 isoform X2. (225 aa)
	SLC17A4	Probable small intestine urate exporter. (528 aa)
	SLC17A1	Sodium-dependent phosphate transport protein 1. (471 aa)
	SLC17A2	Sodium-dependent phosphate transport protein 3 isoform X2. (478 aa)
	SLC9A3	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (897 aa)
	SLC9A3R2	Na(+)/H(+) exchange regulatory cofactor NHE-RF2. (221 aa)
	SLC34A1	Sodium-dependent phosphate transport protein 2A. (607 aa)
	SLC37A1	Solute carrier family 37 member 1. (532 aa)
	SLC20A2	Phosphate transporter; Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport. Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. (636 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANO1	CFTR	ENSUMAP00000009616	ENSUMAP00000003642	Anoctamin.	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	0.534
ANO1	SLC26A6	ENSUMAP00000009616	ENSUMAP00000000428	Anoctamin.	LOW QUALITY PROTEIN: solute carrier family 26 member 6.	0.633
ANO1	SLC26A9	ENSUMAP00000009616	ENSUMAP00000004937	Anoctamin.	Solute carrier family 26 member 9; DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.	0.647
CFTR	ANO1	ENSUMAP00000003642	ENSUMAP00000009616	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	Anoctamin.	0.534
CFTR	CLCN2	ENSUMAP00000003642	ENSUMAP00000006854	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	Chloride channel protein.	0.436
CFTR	ENSUMAP00000010835	ENSUMAP00000003642	ENSUMAP00000010835	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	annotation not available	0.919
CFTR	PDZK1	ENSUMAP00000003642	ENSUMAP00000013783	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	Na(+)/H(+) exchange regulatory cofactor NHE-RF3.	0.683
CFTR	SLC26A3	ENSUMAP00000003642	ENSUMAP00000024911	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	Chloride anion exchanger; Chloride/bicarbonate exchanger. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.	0.556
CFTR	SLC26A6	ENSUMAP00000003642	ENSUMAP00000000428	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	LOW QUALITY PROTEIN: solute carrier family 26 member 6.	0.807
CFTR	SLC26A9	ENSUMAP00000003642	ENSUMAP00000004937	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	Solute carrier family 26 member 9; DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.	0.789
CFTR	SLC9A3	ENSUMAP00000003642	ENSUMAP00000030658	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	0.431
CFTR	SLC9A3R2	ENSUMAP00000003642	ENSUMAP00000030804	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	Na(+)/H(+) exchange regulatory cofactor NHE-RF2.	0.713
CLCN2	CFTR	ENSUMAP00000006854	ENSUMAP00000003642	Chloride channel protein.	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	0.436
CLCN2	SLC25A48	ENSUMAP00000006854	ENSUMAP00000023800	Chloride channel protein.	Solute carrier family 25 member 48; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.406
CLCN2	SLC26A3	ENSUMAP00000006854	ENSUMAP00000024911	Chloride channel protein.	Chloride anion exchanger; Chloride/bicarbonate exchanger. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.	0.719
CLCN2	SLC26A6	ENSUMAP00000006854	ENSUMAP00000000428	Chloride channel protein.	LOW QUALITY PROTEIN: solute carrier family 26 member 6.	0.529
CLCN2	SLC26A9	ENSUMAP00000006854	ENSUMAP00000004937	Chloride channel protein.	Solute carrier family 26 member 9; DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.	0.461
CLCN2	SLC31A1	ENSUMAP00000006854	ENSUMAP00000026601	Chloride channel protein.	High affinity copper uptake protein 1.	0.585
ENSUMAP00000010835	CFTR	ENSUMAP00000010835	ENSUMAP00000003642	annotation not available	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	0.919
ENSUMAP00000010835	PDZK1	ENSUMAP00000010835	ENSUMAP00000013783	annotation not available	Na(+)/H(+) exchange regulatory cofactor NHE-RF3.	0.492