STRINGSTRING
UCN2 UCN2 CCKBR CCKBR NPY NPY SPX SPX PTHLH PTHLH NTS NTS PDYN PDYN VIPR1 VIPR1 CCK CCK CRHR2 CRHR2 GHRHR GHRHR ADCYAP1R1 ADCYAP1R1 SMCO3 SMCO3 MC3R MC3R NPSR1 NPSR1 PRLHR PRLHR NMUR2 NMUR2 GHRH GHRH IAPP IAPP SST SST SSTR4 SSTR4 CCKAR CCKAR GPR37L1 GPR37L1 PTH1R PTH1R GALR1 GALR1 MC4R MC4R GRP GRP PROKR2 PROKR2 CRHBP CRHBP NMBR NMBR GLP1R GLP1R GPR37 GPR37 NPFFR2 NPFFR2 TACR1 TACR1 LEP LEP NMU NMU GPR83 GPR83 MBOAT4 MBOAT4 NMS NMS TACR2 TACR2 SSTR2 SSTR2 GHSR GHSR LEPR LEPR SSTR1 SSTR1 NLN NLN GRPR GRPR PSAP PSAP NPS NPS RAMP3 RAMP3 NPBWR1 NPBWR1 OPRK1 OPRK1 PENK PENK NMB NMB ADM ADM NPFF NPFF MLN MLN PRLH PRLH SUCNR1 SUCNR1 GCG GCG AADACL2 AADACL2 FAP FAP UCN3 UCN3 PPY PPY OPRM1 OPRM1 VIPR2 VIPR2 PROK1 PROK1 GAL GAL TAC4 TAC4 CRHR1 CRHR1 GIP GIP NMUR1 NMUR1 FBXO34 FBXO34 NPY2R NPY2R ENSUMAP00000022521 ENSUMAP00000022521 PTH PTH LOC103682377 LOC103682377 TRH TRH GLP2R GLP2R GHRL GHRL QRFP QRFP CALCRL CALCRL PMCH PMCH ADCYAP1 ADCYAP1 CALCR CALCR AGRP AGRP NPY1R NPY1R NPY5R NPY5R TRHR TRHR AFTPH AFTPH PROKR1 PROKR1 SIM1 SIM1 MCHR2 MCHR2 NPBWR2 NPBWR2 TAC1 TAC1 OPRL1 OPRL1 MCHR1 MCHR1 NTSR1 NTSR1 GAST GAST PTH2R PTH2R CALCA CALCA CALCB CALCB GIPR GIPR PROK2 PROK2 VIP VIP LOC103680632 LOC103680632 LOC103669850 LOC103669850
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UCN2Urocortin-2. (112 aa)
CCKBRCholecystokinin B receptor. (421 aa)
NPYPro-neuropeptide Y. (97 aa)
SPXSpexin. (110 aa)
PTHLHParathyroid hormone-related protein. (155 aa)
NTSNeurotensin/neuromedin N. (170 aa)
PDYNLOW QUALITY PROTEIN: proenkephalin-B. (271 aa)
VIPR1Vasoactive intestinal polypeptide receptor 1; Belongs to the G-protein coupled receptor 2 family. (466 aa)
CCKCholecystokinin. (115 aa)
CRHR2Corticotropin-releasing factor receptor 2; Belongs to the G-protein coupled receptor 2 family. (426 aa)
GHRHRGrowth hormone-releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (423 aa)
ADCYAP1R1Pituitary adenylate cyclase-activating polypeptide type I receptor; Belongs to the G-protein coupled receptor 2 family. (497 aa)
SMCO3Single-pass membrane and coiled-coil domain-containing protein 3. (225 aa)
MC3RMelanocortin 3 receptor. (323 aa)
NPSR1Neuropeptide S receptor isoform X1. (374 aa)
PRLHRProlactin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (370 aa)
NMUR2Neuromedin-U receptor 2; Belongs to the G-protein coupled receptor 1 family. (402 aa)
GHRHSomatoliberin. (106 aa)
IAPPIslet amyloid polypeptide. (89 aa)
SSTSomatostatin. (116 aa)
SSTR4Somatostatin receptor type 4; Belongs to the G-protein coupled receptor 1 family. (366 aa)
CCKARCholecystokinin receptor type A; Belongs to the G-protein coupled receptor 1 family. (428 aa)
GPR37L1G protein-coupled receptor 37 like 1. (476 aa)
PTH1RLOW QUALITY PROTEIN: parathyroid hormone/parathyroid hormone-related peptide receptor; Belongs to the G-protein coupled receptor 2 family. (326 aa)
GALR1Galanin receptor type 1; Belongs to the G-protein coupled receptor 1 family. (349 aa)
MC4RMelanocortin receptor 4. (333 aa)
GRPGastrin-releasing peptide. (182 aa)
PROKR2Prokineticin receptor 2; Belongs to the G-protein coupled receptor 1 family. (383 aa)
CRHBPCorticotropin-releasing factor-binding protein. (305 aa)
NMBRneuromedin-B receptor; Belongs to the G-protein coupled receptor 1 family. (390 aa)
GLP1RGlucagon-like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (463 aa)
GPR37G protein-coupled receptor 37. (614 aa)
NPFFR2Neuropeptide FF receptor 2; Belongs to the G-protein coupled receptor 1 family. (425 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
NMUneuromedin-U. (149 aa)
GPR83Probable G-protein coupled receptor 83; Belongs to the G-protein coupled receptor 1 family. (422 aa)
MBOAT4Membrane bound O-acyltransferase domain containing 4; Belongs to the membrane-bound acyltransferase family. (435 aa)
NMSneuromedin-S isoform X6. (168 aa)
TACR2substance-K receptor; Belongs to the G-protein coupled receptor 1 family. (377 aa)
SSTR2Somatostatin receptor type 2; Belongs to the G-protein coupled receptor 1 family. (369 aa)
GHSRGrowth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (368 aa)
LEPRLeptin receptor isoform X1. (1166 aa)
SSTR1Somatostatin receptor type 1; Belongs to the G-protein coupled receptor 1 family. (391 aa)
NLNNeurolysin, mitochondrial. (681 aa)
GRPRGastrin-releasing peptide receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (384 aa)
PSAPProsaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. (545 aa)
NPSNeuropeptide S. (108 aa)
RAMP3Receptor activity-modifying protein 3. (137 aa)
NPBWR1LOW QUALITY PROTEIN: neuropeptides B/W receptor type 1; Belongs to the G-protein coupled receptor 1 family. (309 aa)
OPRK1Kappa-type opioid receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
PENKproenkephalin-A. (280 aa)
NMBneuromedin-B. (69 aa)
ADMADM isoform X1. (203 aa)
NPFFNeuropeptide FF-amide peptide precursor. (114 aa)
MLNPromotilin. (135 aa)
PRLHProlactin releasing hormone. (87 aa)
SUCNR1Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family. (318 aa)
GCGGlucagon. (179 aa)
AADACL2Arylacetamide deacetylase-like 2. (416 aa)
FAPLOW QUALITY PROTEIN: seprase; Belongs to the peptidase S9B family. (760 aa)
UCN3Urocortin-3. (168 aa)
PPYPancreatic polypeptide. (95 aa)
OPRM1LOW QUALITY PROTEIN: mu-type opioid receptor; Belongs to the G-protein coupled receptor 1 family. (468 aa)
VIPR2Vasoactive intestinal polypeptide receptor 2; Belongs to the G-protein coupled receptor 2 family. (423 aa)
PROK1Prokineticin-1. (105 aa)
GALGalanin peptides. (113 aa)
TAC4Tachykinin-4. (106 aa)
CRHR1LOW QUALITY PROTEIN: corticotropin-releasing factor receptor 1; Belongs to the G-protein coupled receptor 2 family. (424 aa)
GIPGastric inhibitory polypeptide. (176 aa)
NMUR1neuromedin-U receptor 1; Belongs to the G-protein coupled receptor 1 family. (381 aa)
FBXO34F-box only protein 34 isoform X1. (715 aa)
NPY2RNeuropeptide Y receptor type 2; Belongs to the G-protein coupled receptor 1 family. (382 aa)
ENSUMAP00000022521annotation not available (129 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
LOC103682377Calcitonin receptor-stimulating peptide 1. (127 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (310 aa)
GLP2RGlucagon-like peptide 2 receptor. (491 aa)
GHRLAppetite-regulating hormone isoform X1. (134 aa)
QRFPPyroglutamylated RFamide peptide. (136 aa)
CALCRLCalcitonin gene-related peptide type 1 receptor isoform X1; Belongs to the G-protein coupled receptor 2 family. (463 aa)
PMCHpro-MCH. (165 aa)
ADCYAP1Pituitary adenylate cyclase-activating polypeptide isoform X2. (161 aa)
CALCRLOW QUALITY PROTEIN: calcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (450 aa)
AGRPAgouti related neuropeptide. (131 aa)
NPY1RLOW QUALITY PROTEIN: neuropeptide Y receptor type 1; Belongs to the G-protein coupled receptor 1 family. (338 aa)
NPY5RNeuropeptide Y receptor type 5. (456 aa)
TRHRThyrotropin-releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (398 aa)
AFTPHAftiphilin isoform X1. (975 aa)
PROKR1Prokineticin receptor 1; Belongs to the G-protein coupled receptor 1 family. (393 aa)
SIM1Single-minded homolog 1. (753 aa)
MCHR2Melanin-concentrating hormone receptor 2; Belongs to the G-protein coupled receptor 1 family. (340 aa)
NPBWR2Neuropeptides B/W receptor type 2. (304 aa)
TAC1Protachykinin-1 isoform X1. (122 aa)
OPRL1Nociceptin receptor; Belongs to the G-protein coupled receptor 1 family. (370 aa)
MCHR1Melanin-concentrating hormone receptor 1. (353 aa)
NTSR1Neurotensin receptor type 1; Belongs to the G-protein coupled receptor 1 family. (386 aa)
GASTGastrin. (104 aa)
PTH2RParathyroid hormone 2 receptor. (534 aa)
CALCACalcitonin receptor-stimulating peptide 2-like. (145 aa)
CALCBCalcitonin related polypeptide beta. (132 aa)
GIPRGastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family. (453 aa)
PROK2Prokineticin-2 isoform X2. (123 aa)
VIPVasoactive intestinal peptide. (170 aa)
LOC103680632Vomeronasal type-1 receptor. (318 aa)
LOC103669850Thyrotropin-releasing hormone receptor-like; Belongs to the G-protein coupled receptor 1 family. (372 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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