STRINGSTRING
L3MBTL3 L3MBTL3 LOC103675989 LOC103675989 ETS2 ETS2 FITM2 FITM2 HDAC7 HDAC7 NFYC NFYC RORC RORC BARHL2 BARHL2 NR1H4 NR1H4 HOXA3 HOXA3 CYP8B1 CYP8B1 TMTC1 TMTC1 ESR1 ESR1 ESRRA ESRRA NCOR2 NCOR2 ETS1 ETS1 BHLHE41 BHLHE41 ARNT ARNT ARNTL2 ARNTL2 ELK4 ELK4 LOC103657157 LOC103657157 ELK3 ELK3 EGR3 EGR3 HDAC8 HDAC8 NR4A2 NR4A2 EGLN1 EGLN1 IER2 IER2 CLOCK CLOCK NCOR1 NCOR1 LOC103658515 LOC103658515 EGR2 EGR2 MSMP MSMP GATA1 GATA1 NPAS2 NPAS2 ENSUMAP00000010273 ENSUMAP00000010273 IRF8 IRF8 TBL1XR1 TBL1XR1 ENSUMAP00000010815 ENSUMAP00000010815 SPDYC SPDYC SRF SRF LOC103669957 LOC103669957 PGR PGR PLAC8 PLAC8 NR4A1 NR4A1 NR4A1-2 NR4A1-2 NR1H2 NR1H2 SPI1 SPI1 RARG RARG SPIB SPIB FKBP5 FKBP5 EGLN3 EGLN3 PPARD PPARD ZNF415 ZNF415 ARNT2 ARNT2 NR3C1 NR3C1 NPAS4 NPAS4 GFI1 GFI1 ZNF467 ZNF467 FBXL3 FBXL3 HDAC3 HDAC3 PER2 PER2 NR2F6 NR2F6 NR0B2 NR0B2 NFYA NFYA RXRB RXRB NR4A3 NR4A3 PLPPR1 PLPPR1 EPAS1 EPAS1 MAGED1 MAGED1 ESR2 ESR2 HIF1A HIF1A IRF2 IRF2 CEBPE CEBPE NR1H3 NR1H3 ENSUMAP00000019681 ENSUMAP00000019681 FKBP4 FKBP4 LOC103676389 LOC103676389 ELF1 ELF1 ENSUMAP00000020126 ENSUMAP00000020126 GABPA GABPA GABPB1 GABPB1 GATA2 GATA2 ENSUMAP00000020810 ENSUMAP00000020810 CRY2 CRY2 GFI1B GFI1B NR3C2 NR3C2 EGR1 EGR1 CLEC9A CLEC9A KLRF1 KLRF1 KLRB1 KLRB1 NFIL3 NFIL3 ARNTL ARNTL ENSUMAP00000023706 ENSUMAP00000023706 PER1 PER1 CRY1 CRY1 THRA THRA NR1D1 NR1D1 CSNK1D CSNK1D CRABP2 CRABP2 NAB2 NAB2 PROX1 PROX1 BATF3 BATF3 IRF1 IRF1 LOC103663326 LOC103663326 NR1D2 NR1D2 THRB THRB NCOA2 NCOA2 RARB RARB NFYB NFYB ZBTB14 ZBTB14 NAB1 NAB1 LOC103666342 LOC103666342 PPARA PPARA BHLHE40 BHLHE40 EGLN2 EGLN2 ZFPM2 ZFPM2 KIAA0895L KIAA0895L SPDYA SPDYA TRPS1 TRPS1 ESRRG ESRRG ENSUMAP00000028673 ENSUMAP00000028673 TEF TEF ADGRG1 ADGRG1 EP300 EP300 ZBTB46 ZBTB46 RORB RORB HDAC9 HDAC9 ENSUMAP00000030969 ENSUMAP00000030969 NCOA1 NCOA1 RXRG RXRG HIF1AN HIF1AN ABCA2 ABCA2 RXRA RXRA HIF3A HIF3A NPAS1 NPAS1 MPZ MPZ NR1I3 NR1I3 RORA RORA NCOA3 NCOA3 ZNF471 ZNF471 NR1I2 NR1I2 NR5A2 NR5A2 NR2F2 NR2F2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
L3MBTL3Lethal(3)malignant brain tumor-like protein 3 isoform X2. (755 aa)
LOC103675989L-gulonolactone oxidase-like. (408 aa)
ETS2Protein C-ets-2; Transcription factor; Belongs to the ETS family. (469 aa)
FITM2Fat storage-inducing transmembrane protein 2. (262 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (810 aa)
NFYCNuclear transcription factor Y subunit gamma isoform X2. (431 aa)
RORCNuclear receptor ROR-gamma isoform X1. (518 aa)
BARHL2LOW QUALITY PROTEIN: barH-like 2 homeobox protein. (321 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
HOXA3Homeobox protein Hox-A3. (118 aa)
CYP8B1LOW QUALITY PROTEIN: 5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase; Belongs to the cytochrome P450 family. (465 aa)
TMTC1Transmembrane and TPR repeat-containing protein 1 isoform X2. (891 aa)
ESR1LOW QUALITY PROTEIN: estrogen receptor. (328 aa)
ESRRALOW QUALITY PROTEIN: steroid hormone receptor ERR1. (414 aa)
NCOR2Nuclear receptor corepressor 2. (2249 aa)
ETS1ETS proto-oncogene 1, transcription factor; Transcription factor; Belongs to the ETS family. (468 aa)
BHLHE41Basic helix-loop-helix family member e41. (462 aa)
ARNTAryl hydrocarbon receptor nuclear translocator isoform X1. (840 aa)
ARNTL2Aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform X1. (653 aa)
ELK4ETS domain-containing protein Elk-4. (433 aa)
LOC103657157LOW QUALITY PROTEIN: carcinoembryonic antigen-related cell adhesion molecule 1-like. (303 aa)
ELK3ETS domain-containing protein Elk-3. (402 aa)
EGR3Early growth response protein 3. (335 aa)
HDAC8Histone deacetylase 8. (351 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (605 aa)
EGLN1Egl nine homolog 1. (176 aa)
IER2Immediate early response gene 2 protein. (121 aa)
CLOCKCircadian locomoter output cycles protein kaput isoform X1. (863 aa)
NCOR1Nuclear receptor corepressor 1-like. (1398 aa)
LOC103658515Nuclear receptor corepressor 1. (248 aa)
EGR2LOW QUALITY PROTEIN: E3 SUMO-protein ligase EGR2. (323 aa)
MSMPBeta-microseminoprotein. (139 aa)
GATA1LOW QUALITY PROTEIN: erythroid transcription factor. (438 aa)
NPAS2Neuronal PAS domain-containing protein 2. (803 aa)
ENSUMAP00000010273annotation not available (168 aa)
IRF8Interferon regulatory factor 8. (189 aa)
TBL1XR1F-box-like/WD repeat-containing protein TBL1XR1. (531 aa)
ENSUMAP00000010815annotation not available (220 aa)
SPDYCLOW QUALITY PROTEIN: speedy protein C. (228 aa)
SRFSerum response factor. (446 aa)
LOC103669957Speedy protein E4-like. (226 aa)
PGRProgesterone receptor. (448 aa)
PLAC8Placenta-specific gene 8 protein. (113 aa)
NR4A1LOW QUALITY PROTEIN: nuclear receptor subfamily 4 group A member 1. (383 aa)
NR4A1-2Nuclear receptor subfamily 4 group A member 1. (158 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (479 aa)
SPI1Transcription factor PU.1. (257 aa)
RARGRetinoic acid receptor gamma isoform X1. (458 aa)
SPIBTranscription factor Spi-B. (264 aa)
FKBP5Peptidylprolyl isomerase. (458 aa)
EGLN3Egl-9 family hypoxia inducible factor 3. (239 aa)
PPARDLOW QUALITY PROTEIN: peroxisome proliferator-activated receptor delta. (397 aa)
ZNF415Zinc finger protein 415. (424 aa)
ARNT2Aryl hydrocarbon receptor nuclear translocator 2. (647 aa)
NR3C1Nuclear receptor subfamily 3 group C member 1. (781 aa)
NPAS4Neuronal PAS domain-containing protein 4. (800 aa)
GFI1Growth factor independent 1 transcriptional repressor. (135 aa)
ZNF467Zinc finger protein 467. (125 aa)
FBXL3F-box and leucine rich repeat protein 3. (410 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
PER2LOW QUALITY PROTEIN: period circadian protein homolog 2. (1236 aa)
NR2F6Nuclear receptor subfamily 2 group F member 6. (127 aa)
NR0B2Nuclear receptor subfamily 0 group B member 2. (279 aa)
NFYANuclear transcription factor Y subunit alpha. (347 aa)
RXRBRetinoic acid receptor RXR-beta. (546 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (567 aa)
PLPPR1Lipid phosphate phosphatase-related protein type 1. (316 aa)
EPAS1Endothelial PAS domain-containing protein 1. (863 aa)
MAGED1Melanoma-associated antigen D1 isoform X1. (821 aa)
ESR2Estrogen receptor beta isoform X1. (530 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X2. (823 aa)
IRF2Interferon regulatory factor 2 isoform X1. (398 aa)
CEBPECCAAT/enhancer-binding protein. (249 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (447 aa)
ENSUMAP00000019681annotation not available (148 aa)
FKBP4Peptidylprolyl isomerase. (414 aa)
LOC103676389Casein kinase I isoform epsilon-like; Belongs to the protein kinase superfamily. (459 aa)
ELF1ETS-related transcription factor Elf-1. (617 aa)
ENSUMAP00000020126annotation not available (272 aa)
GABPAGA binding protein transcription factor subunit alpha. (454 aa)
GABPB1GA binding protein transcription factor subunit beta 1. (383 aa)
GATA2Endothelial transcription factor GATA-2. (479 aa)
ENSUMAP00000020810annotation not available (156 aa)
CRY2Cryptochrome-2. (582 aa)
GFI1BZinc finger protein Gfi-1b isoform X1. (327 aa)
NR3C2Mineralocorticoid receptor isoform X1. (971 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (523 aa)
CLEC9AC-type lectin domain family 9 member A isoform X1. (241 aa)
KLRF1Killer cell lectin-like receptor subfamily F member 1 isoform X1. (242 aa)
KLRB1Killer cell lectin-like receptor subfamily B member 1 isoform X1. (213 aa)
NFIL3Nuclear factor interleukin-3-regulated protein. (462 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X3. (657 aa)
ENSUMAP00000023706annotation not available (160 aa)
PER1Period circadian protein homolog 1. (818 aa)
CRY1Cryptochrome circadian regulator 1. (587 aa)
THRAThyroid hormone receptor alpha. (570 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
CSNK1DCasein kinase I isoform delta isoform X1. (430 aa)
CRABP2Cellular retinoic acid-binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (138 aa)
NAB2LOW QUALITY PROTEIN: NGFI-A-binding protein 2. (482 aa)
PROX1Prospero homeobox protein 1. (737 aa)
BATF3Basic leucine zipper transcriptional factor ATF-like 3. (121 aa)
IRF1Interferon regulatory factor. (338 aa)
LOC103663326Histone-arginine methyltransferase CARM1-like; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (537 aa)
NR1D2Nuclear receptor subfamily 1 group D member 2. (575 aa)
THRBThyroid hormone receptor beta. (546 aa)
NCOA2Nuclear receptor coactivator. (1433 aa)
RARBRetinoic acid receptor beta-like. (441 aa)
NFYBNuclear transcription factor Y subunit beta. (207 aa)
ZBTB14Zinc finger and BTB domain-containing protein 14. (449 aa)
NAB1NGFI-A-binding protein 1 isoform X1. (486 aa)
LOC103666342F-box-like/WD repeat-containing protein TBL1X. (526 aa)
PPARAPeroxisome proliferator-activated receptor alpha isoform X1. (468 aa)
BHLHE40Class E basic helix-loop-helix protein 40. (412 aa)
EGLN2Egl-9 family hypoxia inducible factor 2. (462 aa)
ZFPM2Zinc finger protein ZFPM2. (1193 aa)
KIAA0895LUncharacterized protein KIAA0895-like homolog. (430 aa)
SPDYASpeedy protein A. (311 aa)
TRPS1Zinc finger transcription factor Trps1. (1183 aa)
ESRRGLOW QUALITY PROTEIN: estrogen-related receptor gamma. (440 aa)
ENSUMAP00000028673annotation not available (126 aa)
TEFTEF transcription factor, PAR bZIP family member. (273 aa)
ADGRG1LOW QUALITY PROTEIN: G-protein coupled receptor 56; Belongs to the G-protein coupled receptor 2 family. (660 aa)
EP300LOW QUALITY PROTEIN: histone acetyltransferase p300. (2390 aa)
ZBTB46Zinc finger and BTB domain-containing protein 46. (467 aa)
RORBLOW QUALITY PROTEIN: nuclear receptor ROR-beta. (467 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (742 aa)
ENSUMAP00000030969annotation not available (251 aa)
NCOA1Nuclear receptor coactivator. (1440 aa)
RXRGRetinoic acid receptor RXR-gamma. (403 aa)
HIF1ANHypoxia-inducible factor 1-alpha inhibitor. (373 aa)
ABCA2ATP-binding cassette sub-family A member 2. (288 aa)
RXRARetinoic acid receptor RXR-alpha. (437 aa)
HIF3AHypoxia-inducible factor 3-alpha. (596 aa)
NPAS1Neuronal PAS domain-containing protein 1. (266 aa)
MPZLOW QUALITY PROTEIN: myelin protein P0. (238 aa)
NR1I3Nuclear receptor subfamily 1 group I member 3 isoform X2. (349 aa)
RORALOW QUALITY PROTEIN: nuclear receptor ROR-alpha. (522 aa)
NCOA3Nuclear receptor coactivator. (1435 aa)
ZNF471Zinc finger protein 471. (696 aa)
NR1I2Nuclear receptor subfamily 1 group I member 2. (425 aa)
NR5A2Nuclear receptor subfamily 5 group A member 2 isoform X3. (501 aa)
NR2F2Nuclear receptor subfamily 2 group F member 2. (281 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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