81 items (Ursus maritimus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SLAMF1	Signaling lymphocytic activation molecule isoform X2. (338 aa)
	CRTAM	Cytotoxic and regulatory T-cell molecule isoform X1. (391 aa)
	KMT5B	Histone-lysine N-methyltransferase SUV420H1 isoform X1. (697 aa)
	MSH2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (909 aa)
	ARID5A	AT-rich interactive domain-containing protein 5A. (437 aa)
	ENSUMAP00000017801	annotation not available (339 aa)
	TAP2	Antigen peptide transporter 2 isoform X1. (703 aa)
	VAV1	Vav guanine nucleotide exchange factor 1. (845 aa)
	ZP3	Zona pellucida sperm-binding protein 3. (426 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
	CLCF1	Cardiotrophin-like cytokine factor 1. (215 aa)
	TREML1	Triggering receptor expressed on myeloid cells like 1. (313 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2 isoform X2. (322 aa)
	EXOSC3	Exosome complex component RRP40. (275 aa)
	PRKCZ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (557 aa)
	CD160	LOW QUALITY PROTEIN: CD160 antigen. (147 aa)
	TP53BP1	LOW QUALITY PROTEIN: tumor suppressor p53-binding protein 1. (1955 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (331 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (124 aa)
	FADD	FAS-associated death domain protein. (192 aa)
	FOXP3	Forkhead box protein P3. (314 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (217 aa)
	P2RX7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (601 aa)
	ENSUMAP00000008398	annotation not available (577 aa)
	WHSC1	LOW QUALITY PROTEIN: histone-lysine N-methyltransferase NSD2. (629 aa)
	CD81	Tetraspanin. (429 aa)
	NOD2	Nucleotide-binding oligomerization domain-containing protein 2. (817 aa)
	LOC103677394	Transforming growth factor beta-1. (299 aa)
	FBXO38	LOW QUALITY PROTEIN: F-box only protein 38. (1167 aa)
	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1. (771 aa)
	LAG3	Lymphocyte activation gene 3 protein. (502 aa)
	SASH3	SAM and SH3 domain-containing protein 3. (321 aa)
	IL21	Interleukin; Belongs to the IL-15/IL-21 family. (153 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
	CD226	CD226 molecule. (336 aa)
	CD1D	Antigen-presenting glycoprotein CD1d. (231 aa)
	SH2D1B	SH2 domain-containing protein 1B. (143 aa)
	MAD2L2	Mitotic spindle assembly checkpoint protein MAD2B. (308 aa)
	PVR	Poliovirus receptor. (427 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (494 aa)
	NECTIN2	Nectin-2. (543 aa)
	STAT5B	Signal transducer and activator of transcription. (787 aa)
	STX7	Syntaxin-7; Belongs to the syntaxin family. (261 aa)
	SH2D1A	SH2 domain-containing protein 1A. (83 aa)
	SUV420H2	Histone-lysine N-methyltransferase SUV420H2. (141 aa)
	DENND1B	LOW QUALITY PROTEIN: DENN domain-containing protein 1B. (736 aa)
	PTPRC	Receptor-type tyrosine-protein phosphatase C isoform X1. (1268 aa)
	TBX21	LOW QUALITY PROTEIN: T-box transcription factor TBX21. (388 aa)
	KLRD1	Natural killer cells antigen CD94 isoform X1. (179 aa)
	KLRK1	NKG2-D type II integral membrane protein isoform X1. (180 aa)
	LOC103669128	NKG2-A/NKG2-B type II integral membrane protein-like isoform X1. (180 aa)
	LOC103669171	Killer cell lectin-like receptor 3. (267 aa)
	ATAD5	ATPase family AAA domain-containing protein 5. (1847 aa)
	HMCES	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (324 aa)
	LTA	Lymphotoxin-alpha; Belongs to the tumor necrosis factor family. (204 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	NCR3	LOW QUALITY PROTEIN: natural cytotoxicity triggering receptor 3. (182 aa)
	FCER2	Low affinity immunoglobulin epsilon Fc receptor. (345 aa)
	RASGRP1	RAS guanyl-releasing protein 1 isoform X1. (807 aa)
	PAXIP1	PAX-interacting protein 1. (908 aa)
	TNFSF13	Tumor necrosis factor ligand superfamily member 13-like isoform X1; Belongs to the tumor necrosis factor family. (242 aa)
	C17orf99	Uncharacterized protein C17orf99 homolog isoform X3. (247 aa)
	ZBTB1	Zinc finger and BTB domain-containing protein 1. (644 aa)
	CD1B	T-cell surface glycoprotein CD1b-like. (333 aa)
	LOC103672138	T-cell surface glycoprotein CD1e, membrane-associated-like. (249 aa)
	RSAD2	LOW QUALITY PROTEIN: radical S-adenosyl methionine domain-containing protein 2. (348 aa)
	CADM1	Cell adhesion molecule 1. (441 aa)
	TFRC	Transferrin receptor protein 1 isoform X1. (770 aa)
	RIF1	Replication timing regulatory factor 1. (2473 aa)
	HPX	Hemopexin. (396 aa)
	SLAMF6	SLAM family member 6 isoform X1. (265 aa)
	FAM49B	Family with sequence similarity 49 member B. (367 aa)
	CD28	T-cell-specific surface glycoprotein CD28. (277 aa)
	LAMP1	Lysosome-associated membrane glycoprotein 1. (406 aa)
	IL18R1	Interleukin-18 receptor 1. (452 aa)
	GIMAP5	GTPase IMAP family member 5 isoform X1. (488 aa)
	AP1G1	AP-1 complex subunit gamma. (822 aa)
	STAT6	Signal transducer and activator of transcription. (846 aa)
	LOC103672078	T-cell surface glycoprotein CD1a-like. (332 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
	IL23A	Interleukin-23 subunit alpha. (190 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AP1G1	STX7	ENSUMAP00000024744	ENSUMAP00000033900	AP-1 complex subunit gamma.	Syntaxin-7; Belongs to the syntaxin family.	0.447
ARID5A	ENSUMAP00000017801	ENSUMAP00000017804	ENSUMAP00000017801	AT-rich interactive domain-containing protein 5A.	annotation not available	0.900
ATAD5	B2M	ENSUMAP00000020850	ENSUMAP00000010286	ATPase family AAA domain-containing protein 5.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.504
ATAD5	MAD2L2	ENSUMAP00000020850	ENSUMAP00000031711	ATPase family AAA domain-containing protein 5.	Mitotic spindle assembly checkpoint protein MAD2B.	0.549
B2M	ATAD5	ENSUMAP00000010286	ENSUMAP00000020850	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	ATPase family AAA domain-containing protein 5.	0.504
B2M	CD1B	ENSUMAP00000010286	ENSUMAP00000005479	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	T-cell surface glycoprotein CD1b-like.	0.827
B2M	CD1D	ENSUMAP00000010286	ENSUMAP00000005580	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Antigen-presenting glycoprotein CD1d.	0.827
B2M	KLRD1	ENSUMAP00000010286	ENSUMAP00000022210	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Natural killer cells antigen CD94 isoform X1.	0.576
B2M	LOC103672078	ENSUMAP00000010286	ENSUMAP00000005489	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	T-cell surface glycoprotein CD1a-like.	0.727
B2M	LOC103672138	ENSUMAP00000010286	ENSUMAP00000005471	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	T-cell surface glycoprotein CD1e, membrane-associated-like.	0.827
B2M	MAD2L2	ENSUMAP00000010286	ENSUMAP00000031711	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Mitotic spindle assembly checkpoint protein MAD2B.	0.542
B2M	MSH2	ENSUMAP00000010286	ENSUMAP00000017927	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.646
B2M	TAP2	ENSUMAP00000010286	ENSUMAP00000017367	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Antigen peptide transporter 2 isoform X1.	0.591
B2M	TFRC	ENSUMAP00000010286	ENSUMAP00000004002	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Transferrin receptor protein 1 isoform X1.	0.720
CADM1	CRTAM	ENSUMAP00000004647	ENSUMAP00000031182	Cell adhesion molecule 1.	Cytotoxic and regulatory T-cell molecule isoform X1.	0.884
CD160	KLRD1	ENSUMAP00000013791	ENSUMAP00000022210	LOW QUALITY PROTEIN: CD160 antigen.	Natural killer cells antigen CD94 isoform X1.	0.518
CD160	LTA	ENSUMAP00000013791	ENSUMAP00000020608	LOW QUALITY PROTEIN: CD160 antigen.	Lymphotoxin-alpha; Belongs to the tumor necrosis factor family.	0.479
CD1B	B2M	ENSUMAP00000005479	ENSUMAP00000010286	T-cell surface glycoprotein CD1b-like.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.827
CD1B	CD1D	ENSUMAP00000005479	ENSUMAP00000005580	T-cell surface glycoprotein CD1b-like.	Antigen-presenting glycoprotein CD1d.	0.904
CD1D	B2M	ENSUMAP00000005580	ENSUMAP00000010286	Antigen-presenting glycoprotein CD1d.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.827