STRINGSTRING
STC2 STC2 COPA COPA UCN2 UCN2 EDN3 EDN3 LOC103657111 LOC103657111 TTR TTR NPY NPY SPX SPX TG TG PTHLH PTHLH NTS NTS CCK CCK ADM5 ADM5 GNRH2 GNRH2 GHRH GHRH IAPP IAPP SST SST ADIPOQ ADIPOQ TMPO TMPO ENSUMAP00000005331 ENSUMAP00000005331 GNRH1 GNRH1 RLN3 RLN3 STC1 STC1 RETNLB RETNLB GRP GRP CHGB CHGB THPO THPO LEP LEP ENHO ENHO INS-IGF2 INS-IGF2 NMU NMU CARTPT CARTPT GPHA2 GPHA2 FNDC5 FNDC5 PRL PRL NMB NMB INHBA INHBA ADM ADM CGA CGA NPFF NPFF EPO EPO MLN MLN TSHB TSHB PRLH PRLH GCG GCG FAP FAP UCN3 UCN3 PPY PPY GPHB5 GPHB5 FBN1 FBN1 GAL GAL RETN RETN GIP GIP NPPC NPPC C1QTNF9 C1QTNF9 PTH PTH INSL6 INSL6 LOC103682377 LOC103682377 TRH TRH LOC103665901 LOC103665901 METRNL METRNL EDN1 EDN1 INHA INHA HAMP HAMP GHRL GHRL QRFP QRFP IGF1 IGF1 PMCH PMCH FSHB FSHB ADCYAP1 ADCYAP1 AGRP AGRP INHBC INHBC INHBE INHBE GALP GALP APELA APELA FNDC4 FNDC4 ECRG4 ECRG4 BMP10 BMP10 ANGPTL8 ANGPTL8 GAST GAST NPPB NPPB NPPA NPPA CALCA CALCA CALCB CALCB UTS2 UTS2 VIP VIP EDN2 EDN2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STC2Stanniocalcin-2. (302 aa)
COPACoatomer subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. (1224 aa)
UCN2Urocortin-2. (112 aa)
EDN3Endothelin-3. (192 aa)
LOC103657111Lutropin subunit beta. (140 aa)
TTRTransthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. (147 aa)
NPYPro-neuropeptide Y. (97 aa)
SPXSpexin. (110 aa)
TGLOW QUALITY PROTEIN: thyroglobulin. (896 aa)
PTHLHParathyroid hormone-related protein. (155 aa)
NTSNeurotensin/neuromedin N. (170 aa)
CCKCholecystokinin. (115 aa)
ADM5LOW QUALITY PROTEIN: putative adrenomedullin-5-like protein. (107 aa)
GNRH2Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (118 aa)
GHRHSomatoliberin. (106 aa)
IAPPIslet amyloid polypeptide. (89 aa)
SSTSomatostatin. (116 aa)
ADIPOQAdiponectin isoform X2. (297 aa)
TMPOThymopoietin. (610 aa)
ENSUMAP00000005331annotation not available (102 aa)
GNRH1Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (92 aa)
RLN3Relaxin-3. (134 aa)
STC1Stanniocalcin-1. (247 aa)
RETNLBResistin-like beta. (109 aa)
GRPGastrin-releasing peptide. (182 aa)
CHGBSecretogranin-1 isoform X1. (716 aa)
THPOLOW QUALITY PROTEIN: thrombopoietin. (338 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
ENHOEnergy homeostasis associated. (76 aa)
INS-IGF2Insulin, isoform 2-like; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (199 aa)
NMUneuromedin-U. (149 aa)
CARTPTCocaine- and amphetamine-regulated transcript protein. (127 aa)
GPHA2Uncharacterized protein C11orf85 isoform X1. (127 aa)
FNDC5Fibronectin type III domain-containing protein 5. (137 aa)
PRLProlactin. (245 aa)
NMBneuromedin-B. (69 aa)
INHBAInhibin subunit beta A. (424 aa)
ADMADM isoform X1. (203 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (120 aa)
NPFFNeuropeptide FF-amide peptide precursor. (114 aa)
EPOLOW QUALITY PROTEIN: erythropoietin. (192 aa)
MLNPromotilin. (135 aa)
TSHBThyroid stimulating hormone subunit beta. (140 aa)
PRLHProlactin releasing hormone. (87 aa)
GCGGlucagon. (179 aa)
FAPLOW QUALITY PROTEIN: seprase; Belongs to the peptidase S9B family. (760 aa)
UCN3Urocortin-3. (168 aa)
PPYPancreatic polypeptide. (95 aa)
GPHB5Glycoprotein hormone subunit beta 5. (130 aa)
FBN1Fibrillin-1. (2958 aa)
GALGalanin peptides. (113 aa)
RETNResistin. (129 aa)
GIPGastric inhibitory polypeptide. (176 aa)
NPPCC-type natriuretic peptide. (74 aa)
C1QTNF9Complement C1q and tumor necrosis factor-related protein 9A isoform X2. (333 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
INSL6Insulin-like peptide INSL6; May have a role in sperm development and fertilization. Belongs to the insulin family. (212 aa)
LOC103682377Calcitonin receptor-stimulating peptide 1. (127 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (310 aa)
LOC103665901Somatotropin-like. (164 aa)
METRNLMeteorin-like protein. (358 aa)
EDN1Endothelin-1. (202 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (344 aa)
HAMPHepcidin. (81 aa)
GHRLAppetite-regulating hormone isoform X1. (134 aa)
QRFPPyroglutamylated RFamide peptide. (136 aa)
IGF1Insulin-like growth factor I isoform X1. (184 aa)
PMCHpro-MCH. (165 aa)
FSHBFollicle stimulating hormone subunit beta. (129 aa)
ADCYAP1Pituitary adenylate cyclase-activating polypeptide isoform X2. (161 aa)
AGRPAgouti related neuropeptide. (131 aa)
INHBCInhibin subunit beta C. (352 aa)
INHBEInhibin subunit beta E. (351 aa)
GALPGalanin-like peptide. (114 aa)
APELAApelin receptor early endogenous ligand. (54 aa)
FNDC4Fibronectin type III domain-containing protein 4. (246 aa)
ECRG4ECRG4 augurin precursor. (147 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
ANGPTL8Angiopoietin like 8. (198 aa)
GASTGastrin. (104 aa)
NPPBNatriuretic peptides B. (132 aa)
NPPANatriuretic peptides A. (182 aa)
CALCACalcitonin receptor-stimulating peptide 2-like. (145 aa)
CALCBCalcitonin related polypeptide beta. (132 aa)
UTS2Urotensin-2. (115 aa)
VIPVasoactive intestinal peptide. (170 aa)
EDN2Endothelin-2. (257 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
Server load: low (20%) [HD]