50 items (Ursus maritimus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	PYCARD	Apoptosis-associated speck-like protein containing a CARD isoform X1. (194 aa)
	HIP1	Huntingtin-interacting protein 1. (1000 aa)
	NLRP1	NACHT, LRR and PYD domains-containing protein 1. (1436 aa)
	ENSUMAP00000017050	annotation not available (80 aa)
	ANP32B	Acidic leucine-rich nuclear phosphoprotein 32 family member B. (272 aa)
	LOC103665481	Putative Bcl-2 homologous antagonist/killer 2. (349 aa)
	SMAD3	Mothers against decapentaplegic homolog. (280 aa)
	CASP2	Caspase-2 isoform X1; Belongs to the peptidase C14A family. (452 aa)
	AIFM1	Apoptosis inducing factor mitochondria associated 1. (612 aa)
	BID	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa)
	CASP8AP2	Caspase 8 associated protein 2. (1994 aa)
	CTSH	LOW QUALITY PROTEIN: pro-cathepsin H; Belongs to the peptidase C1 family. (295 aa)
	BOK	Bcl-2-related ovarian killer protein. (300 aa)
	EGLN3	Egl-9 family hypoxia inducible factor 3. (239 aa)
	MTCH1	LOW QUALITY PROTEIN: mitochondrial carrier homolog 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (280 aa)
	RACK1	Guanine nucleotide-binding protein subunit beta-2-like 1. (374 aa)
	LAPTM5	Lysosomal-associated transmembrane protein 5. (292 aa)
	F3	Tissue factor. (295 aa)
	PDCD2	Programmed cell death protein 2. (284 aa)
	P2RX1	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
	DLC1-2	Rho GTPase-activating protein 7 isoform X5. (361 aa)
	S100A8	Protein S100; Belongs to the S-100 family. (136 aa)
	S100A9	Protein S100; Belongs to the S-100 family. (130 aa)
	CFLAR	CASP8 and FADD-like apoptosis regulator isoform X2; Belongs to the peptidase C14A family. (482 aa)
	CASP10	Caspase-10 isoform X1; Belongs to the peptidase C14A family. (481 aa)
	CASP8	Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
	CASP9	Caspase-9 isoform X1; Belongs to the peptidase C14A family. (413 aa)
	DAP	Death-associated protein 1. (77 aa)
	PDCD6	Programmed cell death protein 6. (185 aa)
	FAM162A	Protein FAM162A. (155 aa)
	ATP2A3	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (982 aa)
	TNFSF15	Tumor necrosis factor ligand superfamily member 15. (174 aa)
	ENSUMAP00000008777	annotation not available (79 aa)
	PIDD1	LOW QUALITY PROTEIN: p53-induced death domain-containing protein 1. (844 aa)
	DIABLO	Diablo homolog, mitochondrial. (270 aa)
	IFT57	Intraflagellar transport protein 57 homolog. (390 aa)
	PML	Promyelocytic leukemia. (880 aa)
	HIP1R	Huntingtin-interacting protein 1-related protein. (915 aa)
	PMAIP1	Phorbol-12-myristate-13-acetate-induced protein 1. (53 aa)
	CRADD	CASP2 and RIPK1 domain containing adaptor with death domain. (250 aa)
	BAD	Bcl2-associated agonist of cell death. (168 aa)
	NOD1	Nucleotide-binding oligomerization domain-containing protein 1. (263 aa)
	CYCS	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	BAX	Apoptosis regulator BAX. (221 aa)
	SENP1	Sentrin-specific protease 1 isoform X2. (637 aa)
	FASLG	Tumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (269 aa)
	MUL1	Mitochondrial ubiquitin ligase activator of NFKB 1. (252 aa)
	ENSUMAP00000023183	annotation not available (141 aa)
	ACER2	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (288 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIFM1	BAX	ENSUMAP00000016064	ENSUMAP00000001480	Apoptosis inducing factor mitochondria associated 1.	Apoptosis regulator BAX.	0.914
AIFM1	CYCS	ENSUMAP00000016064	ENSUMAP00000001665	Apoptosis inducing factor mitochondria associated 1.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.401
BAD	BAX	ENSUMAP00000003173	ENSUMAP00000001480	Bcl2-associated agonist of cell death.	Apoptosis regulator BAX.	0.857
BAD	BID	ENSUMAP00000003173	ENSUMAP00000015536	Bcl2-associated agonist of cell death.	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	0.731
BAD	BOK	ENSUMAP00000003173	ENSUMAP00000014244	Bcl2-associated agonist of cell death.	Bcl-2-related ovarian killer protein.	0.824
BAD	CASP2	ENSUMAP00000003173	ENSUMAP00000016144	Bcl2-associated agonist of cell death.	Caspase-2 isoform X1; Belongs to the peptidase C14A family.	0.558
BAD	CASP9	ENSUMAP00000003173	ENSUMAP00000030022	Bcl2-associated agonist of cell death.	Caspase-9 isoform X1; Belongs to the peptidase C14A family.	0.623
BAD	CFLAR	ENSUMAP00000003173	ENSUMAP00000029777	Bcl2-associated agonist of cell death.	CASP8 and FADD-like apoptosis regulator isoform X2; Belongs to the peptidase C14A family.	0.414
BAD	LOC103665481	ENSUMAP00000003173	ENSUMAP00000016562	Bcl2-associated agonist of cell death.	Putative Bcl-2 homologous antagonist/killer 2.	0.848
BAX	AIFM1	ENSUMAP00000001480	ENSUMAP00000016064	Apoptosis regulator BAX.	Apoptosis inducing factor mitochondria associated 1.	0.914
BAX	BAD	ENSUMAP00000001480	ENSUMAP00000003173	Apoptosis regulator BAX.	Bcl2-associated agonist of cell death.	0.857
BAX	BID	ENSUMAP00000001480	ENSUMAP00000015536	Apoptosis regulator BAX.	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	0.998
BAX	CASP9	ENSUMAP00000001480	ENSUMAP00000030022	Apoptosis regulator BAX.	Caspase-9 isoform X1; Belongs to the peptidase C14A family.	0.507
BAX	CYCS	ENSUMAP00000001480	ENSUMAP00000001665	Apoptosis regulator BAX.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.983
BAX	DIABLO	ENSUMAP00000001480	ENSUMAP00000006863	Apoptosis regulator BAX.	Diablo homolog, mitochondrial.	0.797
BAX	LOC103665481	ENSUMAP00000001480	ENSUMAP00000016562	Apoptosis regulator BAX.	Putative Bcl-2 homologous antagonist/killer 2.	0.982
BAX	PMAIP1	ENSUMAP00000001480	ENSUMAP00000006230	Apoptosis regulator BAX.	Phorbol-12-myristate-13-acetate-induced protein 1.	0.583
BID	BAD	ENSUMAP00000015536	ENSUMAP00000003173	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	Bcl2-associated agonist of cell death.	0.731
BID	BAX	ENSUMAP00000015536	ENSUMAP00000001480	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	Apoptosis regulator BAX.	0.998
BID	BOK	ENSUMAP00000015536	ENSUMAP00000014244	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	Bcl-2-related ovarian killer protein.	0.837