STRINGSTRING
STK4 STK4 DAXX DAXX NF1 NF1 TNF TNF DDX47 DDX47 DEDD2 DEDD2 BAD BAD BAG3 BAG3 DAB2IP DAB2IP PIDD1 PIDD1 IL18 IL18 LOC103671065 LOC103671065 FADD FADD PIK3R1 PIK3R1 DAPK1 DAPK1 DDX3Y DDX3Y SKIL SKIL DDX3X DDX3X STK3 STK3 RAF1 RAF1 FASLG FASLG CASP10 CASP10 CASP8 CASP8 CASP8AP2 CASP8AP2 NGF NGF DELE1 DELE1 ITPRIP ITPRIP DEDD DEDD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STK4Serine/threonine-protein kinase 4. (496 aa)
DAXXDeath domain-associated protein 6. (737 aa)
NF1Neurofibromin. (2862 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
DDX47Probable ATP-dependent RNA helicase DDX47 isoform X1; Belongs to the DEAD box helicase family. (455 aa)
DEDD2DNA-binding death effector domain-containing protein 2. (327 aa)
BADBcl2-associated agonist of cell death. (168 aa)
BAG3BAG family molecular chaperone regulator 3. (551 aa)
DAB2IPDisabled homolog 2-interacting protein. (877 aa)
PIDD1LOW QUALITY PROTEIN: p53-induced death domain-containing protein 1. (844 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (217 aa)
LOC103671065Uncharacterized protein LOC103671065 isoform X3. (435 aa)
FADDFAS-associated death domain protein. (192 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
DAPK1Death-associated protein kinase 1 isoform X2. (1415 aa)
DDX3YLOW QUALITY PROTEIN: ATP-dependent RNA helicase DDX3X-like; Belongs to the DEAD box helicase family. (704 aa)
SKILSki-like protein isoform X2. (664 aa)
DDX3XDEAD-box helicase 3 X-linked. (608 aa)
STK3Serine/threonine-protein kinase 3. (497 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
FASLGTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (269 aa)
CASP10Caspase-10 isoform X1; Belongs to the peptidase C14A family. (481 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
CASP8AP2Caspase 8 associated protein 2. (1994 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (356 aa)
DELE1LOW QUALITY PROTEIN: death ligand signal enhancer. (540 aa)
ITPRIPLOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor-interacting protein. (470 aa)
DEDDDeath effector domain-containing protein. (318 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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