STRINGSTRING
P2RX4 P2RX4 STAT5A STAT5A RIN2 RIN2 ENSUMAP00000034665 ENSUMAP00000034665 AKT1 AKT1 FGF18 FGF18 FLT4 FLT4 PIK3CD PIK3CD FOXP1 FOXP1 PRKD2 PRKD2 MTOR MTOR PDPK1 PDPK1 PDCD6 PDCD6 ANXA1 ANXA1 PLPP3 PLPP3 BMPR2 BMPR2 PRKCA PRKCA ENPP2 ENPP2 IFNG IFNG TGFB2 TGFB2 GPLD1 GPLD1 AAMP AAMP VIL1 VIL1 AKT2 AKT2 GPI GPI ABL1 ABL1 RREB1 RREB1 RAB25 RAB25 PIK3CG PIK3CG PROX1 PROX1 CAPN7 CAPN7 ATP5F1B ATP5F1B MAP3K3 MAP3K3 HMGB1 HMGB1 HMOX1 HMOX1 RTN4 RTN4 EPB41L4B EPB41L4B NRP1 NRP1 ITGB3 ITGB3 JCAD JCAD BMP4 BMP4 HBEGF HBEGF PLCG2 PLCG2 ENSUMAP00000020575 ENSUMAP00000020575 PIK3CB PIK3CB FGF7 FGF7 RAB11B RAB11B BCAR1 BCAR1 PDGFB PDGFB THBS1 THBS1 HIF1A HIF1A RHOJ RHOJ PRKCE PRKCE ENSUMAP00000017592 ENSUMAP00000017592 SRPX2 SRPX2 HSPB1 HSPB1 RAB11A RAB11A PTK2B PTK2B FUT1 FUT1 HDAC7 HDAC7 ZC3H12A ZC3H12A ENSUMAP00000001239 ENSUMAP00000001239 MAPRE2 MAPRE2 FGFBP1 FGFBP1 ATP5F1A ATP5F1A RRAS RRAS PLCG1 PLCG1 MET MET ETS1 ETS1 SASH1 SASH1 PPM1F PPM1F SRC SRC ITGB1BP1 ITGB1BP1 FGF2 FGF2 MAP2K3 MAP2K3 CCBE1 CCBE1 LGMN LGMN AGT AGT LOC103677394 LOC103677394 TEK TEK FGF10 FGF10 VEGFA VEGFA KDR KDR VILL VILL PRKD1 PRKD1 SIRT1 SIRT1 ARF6 ARF6 HDAC6 HDAC6 CIB1 CIB1 ANXA3 ANXA3 ADGRA2 ADGRA2 SMOC2 SMOC2 ADAM9 ADAM9 EMC10 EMC10 SP1 SP1 CTSH CTSH AKT3 AKT3 FGF1 FGF1 LOC103668179 LOC103668179 GLIPR2 GLIPR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (403 aa)
STAT5ASignal transducer and activator of transcription. (793 aa)
RIN2LOW QUALITY PROTEIN: ras and Rab interactor 2. (459 aa)
ENSUMAP00000034665annotation not available (409 aa)
AKT1Non-specific serine/threonine protein kinase. (514 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
FLT4Vascular endothelial growth factor receptor 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1344 aa)
PIK3CDLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; Belongs to the PI3/PI4-kinase family. (855 aa)
FOXP1Forkhead box protein P1. (679 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (833 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2531 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (572 aa)
PDCD6Programmed cell death protein 6. (185 aa)
ANXA1Annexin. (345 aa)
PLPP3Lipid phosphate phosphohydrolase 3. (273 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X1. (940 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
GPLD1Phosphatidylinositol-glycan-specific phospholipase D. (817 aa)
AAMPAngio-associated migratory cell protein. (423 aa)
VIL1Villin-1. (818 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (520 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (585 aa)
ABL1Tyrosine-protein kinase. (1135 aa)
RREB1LOW QUALITY PROTEIN: ras-responsive element-binding protein 1. (1176 aa)
RAB25Ras-related protein Rab-25 isoform X1. (213 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1090 aa)
PROX1Prospero homeobox protein 1. (737 aa)
CAPN7Calpain-7; Belongs to the peptidase C2 family. (813 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (528 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3 isoform X1. (647 aa)
HMGB1High mobility group protein B1. (215 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (264 aa)
RTN4Reticulon. (978 aa)
EPB41L4BBand 4.1-like protein 4B. (836 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (783 aa)
JCADJunctional protein associated with coronary artery disease. (1375 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
HBEGFProheparin-binding EGF-like growth factor. (201 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1191 aa)
ENSUMAP00000020575annotation not available (177 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1067 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
RAB11BRas-related protein Rab-11B. (204 aa)
BCAR1Breast cancer anti-estrogen resistance protein 1. (862 aa)
PDGFBPlatelet-derived growth factor subunit B. (234 aa)
THBS1LOW QUALITY PROTEIN: thrombospondin-1. (1168 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X2. (823 aa)
RHOJRho-related GTP-binding protein RhoJ isoform X1. (236 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (226 aa)
ENSUMAP00000017592annotation not available (120 aa)
SRPX2Sushi repeat containing protein X-linked 2. (465 aa)
HSPB1Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family. (290 aa)
RAB11ARAB11A, member RAS oncogene family. (216 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
FUT1L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (361 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (810 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (582 aa)
ENSUMAP00000001239annotation not available (112 aa)
MAPRE2Microtubule-associated protein RP/EB family member 2 isoform X1. (326 aa)
FGFBP1Fibroblast growth factor-binding protein 1. (255 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (553 aa)
RRASRas-related protein R-Ras. (195 aa)
PLCG1Phosphoinositide phospholipase C. (1178 aa)
METHepatocyte growth factor receptor. (1399 aa)
ETS1ETS proto-oncogene 1, transcription factor; Transcription factor; Belongs to the ETS family. (468 aa)
SASH1SAM and SH3 domain-containing protein 1 isoform X1. (1239 aa)
PPM1FProtein phosphatase 1F. (278 aa)
SRCTyrosine-protein kinase. (618 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
CCBE1Collagen and calcium-binding EGF domain-containing protein 1. (402 aa)
LGMNLegumain. (433 aa)
AGTAngiotensinogen; Belongs to the serpin family. (475 aa)
LOC103677394Transforming growth factor beta-1. (299 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (179 aa)
KDRLOW QUALITY PROTEIN: vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1344 aa)
VILLLOW QUALITY PROTEIN: villin-like protein. (575 aa)
PRKD1Serine/threonine-protein kinase D1. (874 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X2. (446 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (151 aa)
HDAC6LOW QUALITY PROTEIN: histone deacetylase 6. (976 aa)
CIB1Calcium and integrin-binding protein 1. (199 aa)
ANXA3Annexin. (323 aa)
ADGRA2G-protein coupled receptor 124; Belongs to the G-protein coupled receptor 2 family. (1161 aa)
SMOC2SPARC-related modular calcium-binding protein 2. (423 aa)
ADAM9Disintegrin and metalloproteinase domain-containing protein 9 isoform X1. (819 aa)
EMC10ER membrane protein complex subunit 10. (241 aa)
SP1Sp1 transcription factor. (780 aa)
CTSHLOW QUALITY PROTEIN: pro-cathepsin H; Belongs to the peptidase C1 family. (295 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (519 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
LOC103668179LOW QUALITY PROTEIN: high mobility group protein B1-like. (200 aa)
GLIPR2Golgi-associated plant pathogenesis-related protein 1 isoform X2; Belongs to the CRISP family. (80 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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