STRINGSTRING
TESK1 TESK1 ADD1 ADD1 DISC1 DISC1 GPER1 GPER1 GOLGA4 GOLGA4 RNF112 RNF112 GPR68 GPR68 STK11 STK11 LOC103677394 LOC103677394 FOXG1 FOXG1 MYOG MYOG SLC9B2 SLC9B2 NIN NIN DCT DCT FLNA FLNA CARMIL1 CARMIL1 PKHD1L1 PKHD1L1 XRCC5 XRCC5 NUMB-2 NUMB-2 NR2E1 NR2E1 ROCK1 ROCK1 PAX6 PAX6 SIRT2 SIRT2 RELN RELN ENSUMAP00000035037 ENSUMAP00000035037 ZNF335 ZNF335 S1PR2 S1PR2 CAPRIN1 CAPRIN1 ABL1 ABL1 RREB1 RREB1 PLXNB2 PLXNB2 OBSL1 OBSL1 NEDD9 NEDD9 IST1 IST1 SERPINE2 SERPINE2 MYOC MYOC METRNL METRNL IL34 IL34 CDKL3 CDKL3 JADE2 JADE2 PLXND1 PLXND1 PLXNA4 PLXNA4 LIF LIF LRRC45 LRRC45 P4HB P4HB SEMA4D SEMA4D SEMA4D-2 SEMA4D-2 CLEC7A CLEC7A SMARCD3 SMARCD3 PTN PTN NRP1 NRP1 ITGB1 ITGB1 ENSUMAP00000021933 ENSUMAP00000021933 ITGB3 ITGB3 XRCC2 XRCC2 TNFSF11 TNFSF11 BMP4 BMP4 ENSUMAP00000021478 ENSUMAP00000021478 FERMT2 FERMT2 WNT3 WNT3 ZNF488 ZNF488 MAN2A1 MAN2A1 LOC103676398 LOC103676398 TNF TNF SOX10 SOX10 BRAF BRAF EFNA5 EFNA5 FAIM FAIM SLITRK1 SLITRK1 CHODL CHODL PLXNA1 PLXNA1 GFAP GFAP ANKRD27 ANKRD27 LIMK1 LIMK1 LRP2 LRP2 PRKCH PRKCH ENSUMAP00000018664 ENSUMAP00000018664 HIF1A HIF1A CDC42 CDC42 OPRM1 OPRM1 TIAM2 TIAM2 KDM1A KDM1A C1QBP C1QBP CLCF1 CLCF1 KHDC3L KHDC3L DHX36 DHX36 ENSUMAP00000016001 ENSUMAP00000016001 TENM4 TENM4 ACTN3 ACTN3 NGF NGF PRKCI PRKCI MYADM MYADM SRRT SRRT FBXW8 FBXW8 UNC13D UNC13D STK25 STK25 BNC1 BNC1 CRK CRK GLI3 GLI3 DBNL DBNL PLAG1 PLAG1 PRKDC PRKDC SERPINF1 SERPINF1 PREX1 PREX1 DBN1 DBN1 F11R F11R VEGFC VEGFC MTOR MTOR ZFYVE27 ZFYVE27 TRIB1 TRIB1 FZD3 FZD3 LRP8 LRP8 PLXNA2 PLXNA2 TNFRSF1B TNFRSF1B BMPR2 BMPR2 SPEN SPEN UFL1 UFL1 TWF2 TWF2 SOX8 SOX8 CDH5 CDH5 MECP2 MECP2 NPTN NPTN ISLR2 ISLR2 BMP2 BMP2 SEMA7A SEMA7A MAP3K13 MAP3K13 CX3CR1 CX3CR1 NEFL NEFL FGF2 FGF2 TRIM32 TRIM32 CTNNB1 CTNNB1 ADIPOQ ADIPOQ MYF6 MYF6 MYF5 MYF5 PDE3A PDE3A CRKL CRKL TGM2 TGM2 KRAS KRAS PLXNC1 PLXNC1 SHTN1 SHTN1 WNT2 WNT2 LOC103665211 LOC103665211 BAD BAD CASS4 CASS4 LPAR3 LPAR3 LIMS1 LIMS1 IFNG IFNG CAPRIN2 CAPRIN2 ENSUMAP00000001989 ENSUMAP00000001989 S100A10 S100A10 WNT3A WNT3A HES1 HES1 BHLHB9 BHLHB9 ILK ILK SS18L1 SS18L1 PAFAH1B1 PAFAH1B1 IL6ST IL6ST OCM2 OCM2 NUMB NUMB CDKL5 CDKL5 CUL7-2 CUL7-2 CUL7 CUL7 SRF SRF BIN1 BIN1 ELL3 ELL3 LIMS2 LIMS2 ASPA ASPA CIB1 CIB1 CUX2 CUX2 LAYN LAYN SNW1 SNW1 SMO SMO TRPV2 TRPV2 EGR2 EGR2 DMTN DMTN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TESK1Dual specificity testis-specific protein kinase 1. (546 aa)
ADD1Alpha-adducin. (808 aa)
DISC1LOW QUALITY PROTEIN: disrupted in schizophrenia 1 protein. (861 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
GOLGA4LOW QUALITY PROTEIN: golgin subfamily A member 4. (2262 aa)
RNF112RING finger protein 112. (425 aa)
GPR68Ovarian cancer G-protein coupled receptor 1; Belongs to the G-protein coupled receptor 1 family. (211 aa)
STK11Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (457 aa)
LOC103677394Transforming growth factor beta-1. (299 aa)
FOXG1Forkhead box protein G1. (221 aa)
MYOGMyogenin. (208 aa)
SLC9B2Mitochondrial sodium/hydrogen exchanger 9B2. (537 aa)
NINLOW QUALITY PROTEIN: ninein. (1951 aa)
DCTL-dopachrome tautomerase. (516 aa)
FLNAfilamin-A. (2549 aa)
CARMIL1Capping protein regulator and myosin 1 linker 1. (1339 aa)
PKHD1L1fibrocystin-L. (4236 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (731 aa)
NUMB-2Protein numb homolog isoform X7. (70 aa)
NR2E1LOW QUALITY PROTEIN: nuclear receptor subfamily 2 group E member 1. (372 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1355 aa)
PAX6Paired box protein Pax-6 isoform X2. (450 aa)
SIRT2NAD-dependent protein deacetylase sirtuin-2 isoform X1. (471 aa)
RELNLOW QUALITY PROTEIN: reelin. (3457 aa)
ENSUMAP00000035037annotation not available (85 aa)
ZNF335Zinc finger protein 335. (1320 aa)
S1PR2Sphingosine 1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (160 aa)
CAPRIN1Caprin-1. (660 aa)
ABL1Tyrosine-protein kinase. (1135 aa)
RREB1LOW QUALITY PROTEIN: ras-responsive element-binding protein 1. (1176 aa)
PLXNB2LOW QUALITY PROTEIN: plexin-B2. (1590 aa)
OBSL1Obscurin-like protein 1. (1222 aa)
NEDD9Enhancer of filamentation 1. (842 aa)
IST1IST1 factor associated with ESCRT-III. (366 aa)
SERPINE2Glia-derived nexin; Belongs to the serpin family. (397 aa)
MYOCMyocilin. (490 aa)
METRNLMeteorin-like protein. (358 aa)
IL34Interleukin-34 isoform X1. (236 aa)
CDKL3Cyclin-dependent kinase-like 3 isoform X2. (603 aa)
JADE2LOW QUALITY PROTEIN: protein Jade-2. (805 aa)
PLXND1LOW QUALITY PROTEIN: plexin-D1. (1503 aa)
PLXNA4plexin-A4 isoform X1. (1884 aa)
LIFLeukemia inhibitory factor. (204 aa)
LRRC45Leucine-rich repeat-containing protein 45. (619 aa)
P4HBLOW QUALITY PROTEIN: protein disulfide-isomerase. (474 aa)
SEMA4Dsemaphorin-4D; Belongs to the semaphorin family. (777 aa)
SEMA4D-2Semaphorin 4D. (117 aa)
CLEC7AC-type lectin domain family 7 member A isoform X2. (202 aa)
SMARCD3SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3. (502 aa)
PTNPleiotrophin. (210 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
ENSUMAP00000021933annotation not available (135 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (783 aa)
XRCC2X-ray repair cross complementing 2. (279 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (242 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
ENSUMAP00000021478annotation not available (65 aa)
FERMT2Fermitin family homolog 2. (670 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (175 aa)
ZNF488Zinc finger protein 488. (324 aa)
MAN2A1Alpha-mannosidase. (1148 aa)
LOC103676398TRIO and F-actin-binding protein-like. (105 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
SOX10Transcription factor SOX-10. (305 aa)
BRAFSerine/threonine-protein kinase B-raf. (715 aa)
EFNA5ephrin-A5; Belongs to the ephrin family. (188 aa)
FAIMFas apoptotic inhibitory molecule 1. (201 aa)
SLITRK1SLIT and NTRK like family member 1. (696 aa)
CHODLChondrolectin isoform X1. (273 aa)
PLXNA1LOW QUALITY PROTEIN: plexin-A1. (1729 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (515 aa)
ANKRD27LOW QUALITY PROTEIN: ankyrin repeat domain-containing protein 27. (1046 aa)
LIMK1LIM domain kinase 1. (653 aa)
LRP2Low-density lipoprotein receptor-related protein 2. (403 aa)
PRKCHProtein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa)
ENSUMAP00000018664annotation not available (401 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X2. (823 aa)
CDC42Cell division control protein 42 homolog isoform X1. (191 aa)
OPRM1LOW QUALITY PROTEIN: mu-type opioid receptor; Belongs to the G-protein coupled receptor 1 family. (468 aa)
TIAM2T-lymphoma invasion and metastasis-inducing protein 2. (617 aa)
KDM1ALysine-specific histone demethylase 1A isoform X2. (671 aa)
C1QBPComplement component 1 Q subcomponent-binding protein, mitochondrial. (163 aa)
CLCF1Cardiotrophin-like cytokine factor 1. (215 aa)
KHDC3LKHDC3-like protein. (218 aa)
DHX36ATP-dependent RNA helicase DHX36. (1011 aa)
ENSUMAP00000016001annotation not available (97 aa)
TENM4Teneurin-4-like. (2643 aa)
ACTN3Alpha-actinin-3. (925 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (356 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (569 aa)
MYADMLOW QUALITY PROTEIN: myeloid-associated differentiation marker. (305 aa)
SRRTSerrate RNA effector molecule homolog isoform X1. (876 aa)
FBXW8F-box/WD repeat-containing protein 8. (553 aa)
UNC13DLOW QUALITY PROTEIN: protein unc-13 homolog D. (1060 aa)
STK25Serine/threonine-protein kinase 25. (422 aa)
BNC1Zinc finger protein basonuclin-1. (962 aa)
CRKAdapter molecule crk. (287 aa)
GLI3Transcriptional activator GLI3. (524 aa)
DBNLLOW QUALITY PROTEIN: drebrin-like protein. (139 aa)
PLAG1Zinc finger protein PLAG1 isoform X1. (499 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4135 aa)
SERPINF1Pigment epithelium-derived factor; Belongs to the serpin family. (418 aa)
PREX1Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein. (1624 aa)
DBN1LOW QUALITY PROTEIN: drebrin. (966 aa)
F11RJunctional adhesion molecule A. (298 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (436 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2531 aa)
ZFYVE27Zinc finger FYVE-type containing 27. (404 aa)
TRIB1Tribbles homolog 1. (191 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
LRP8LDL receptor related protein 8. (925 aa)
PLXNA2LOW QUALITY PROTEIN: plexin-A2. (1891 aa)
TNFRSF1BLOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1B. (313 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
SPENLOW QUALITY PROTEIN: msx2-interacting protein. (3648 aa)
UFL1E3 UFM1-protein ligase 1. (792 aa)
TWF2Twinfilin actin binding protein 2. (349 aa)
SOX8Transcription factor SOX-8. (216 aa)
CDH5LOW QUALITY PROTEIN: cadherin-5; Cadherins are calcium-dependent cell adhesion proteins. (720 aa)
MECP2methyl-CpG-binding protein 2. (172 aa)
NPTNNeuroplastin. (367 aa)
ISLR2LOW QUALITY PROTEIN: immunoglobulin superfamily containing leucine-rich repeat protein 2. (448 aa)
BMP2Bone morphogenetic protein 2 isoform X2. (395 aa)
SEMA7Asemaphorin-7A; Belongs to the semaphorin family. (662 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (944 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (356 aa)
NEFLNeurofilament light polypeptide; Belongs to the intermediate filament family. (516 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
TRIM32E3 ubiquitin-protein ligase TRIM32. (654 aa)
CTNNB1Catenin beta-1. (787 aa)
ADIPOQAdiponectin isoform X2. (297 aa)
MYF6LOW QUALITY PROTEIN: myogenic factor 6. (225 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
PDE3APhosphodiesterase. (989 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
TGM2Protein-glutamine gamma-glutamyltransferase 2. (687 aa)
KRASGTPase KRas isoform X3. (189 aa)
PLXNC1plexin-C1. (1355 aa)
SHTN1Shootin-1. (623 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (331 aa)
LOC103665211Mothers against decapentaplegic homolog. (244 aa)
BADBcl2-associated agonist of cell death. (168 aa)
CASS4Cas scaffolding protein family member 4. (806 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (354 aa)
LIMS1LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (387 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
CAPRIN2Caprin family member 2. (1067 aa)
ENSUMAP00000001989annotation not available (146 aa)
S100A10Protein S100-A10; Belongs to the S-100 family. (97 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
HES1Transcription factor HES-1. (166 aa)
BHLHB9Protein BHLHb9. (550 aa)
ILKIntegrin-linked protein kinase. (452 aa)
SS18L1Calcium-responsive transactivator. (423 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
IL6STInterleukin-6 receptor subunit beta isoform X1. (918 aa)
OCM2Putative oncomodulin-2; Belongs to the parvalbumin family. (109 aa)
NUMBProtein numb homolog isoform X3. (673 aa)
CDKL5Cyclin-dependent kinase-like 5. (932 aa)
CUL7-2Cullin 7. (229 aa)
CUL7LOW QUALITY PROTEIN: cullin-7; Belongs to the cullin family. (613 aa)
SRFSerum response factor. (446 aa)
BIN1Myc box-dependent-interacting protein 1 isoform X14. (523 aa)
ELL3RNA polymerase II elongation factor ELL3. (324 aa)
LIMS2LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (339 aa)
ASPAAspartoacylase. (313 aa)
CIB1Calcium and integrin-binding protein 1. (199 aa)
CUX2Homeobox protein cut-like. (1499 aa)
LAYNLayilin. (355 aa)
SNW1SNW domain-containing protein 1. (536 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (745 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (797 aa)
EGR2LOW QUALITY PROTEIN: E3 SUMO-protein ligase EGR2. (323 aa)
DMTNDematin. (371 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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