(29 nodes) Positive regulation of glucose transmembrane transport network (Ursus maritimus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

gene neighborhood

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textmining

co-expression

protein homology

Your Input:
	C2CD5	C2 domain-containing protein 5 isoform X1. (1084 aa)
	CREBL2	cAMP-responsive element-binding protein-like 2. (120 aa)
	FGF21	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
	NFE2L2	Nuclear factor erythroid 2-related factor 2 isoform X2. (590 aa)
	BRAF	Serine/threonine-protein kinase B-raf. (715 aa)
	INSR	Tyrosine-protein kinase receptor. (1375 aa)
	RHOQ	Rho-related GTP-binding protein RhoQ. (210 aa)
	MEF2A	Myocyte-specific enhancer factor 2A. (466 aa)
	AKT1	Non-specific serine/threonine protein kinase. (514 aa)
	RNASEL	2-5A-dependent ribonuclease. (725 aa)
	PTH	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
	SLC1A2	Amino acid transporter. (599 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (520 aa)
	IGF1	Insulin-like growth factor I isoform X1. (184 aa)
	APPL1	DCC-interacting protein 13-alpha. (656 aa)
	CLIP3	CAP-Gly domain-containing linker protein 3. (546 aa)
	OSBPL8	Oxysterol-binding protein; Belongs to the OSBP family. (873 aa)
	NR4A3	Nuclear receptor subfamily 4 group A member 3. (567 aa)
	C3	LOW QUALITY PROTEIN: complement C3. (1590 aa)
	GPC3	Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (625 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (519 aa)
	OPN3	Opsin-3; Belongs to the G-protein coupled receptor 1 family. (189 aa)
	PRKCI	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (569 aa)
	CAPN10	Calpain-10; Belongs to the peptidase C2 family. (636 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (600 aa)
	PIK3R1	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	INS-IGF2	Insulin, isoform 2-like; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (199 aa)
	ADIPOQ	Adiponectin isoform X2. (297 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	APPL1	ENSUMAP00000005319	ENSUMAP00000026978	Adiponectin isoform X2.	DCC-interacting protein 13-alpha.	0.516
ADIPOQ	C3	ENSUMAP00000005319	ENSUMAP00000016842	Adiponectin isoform X2.	LOW QUALITY PROTEIN: complement C3.	0.455
ADIPOQ	FGF21	ENSUMAP00000005319	ENSUMAP00000000759	Adiponectin isoform X2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.663
ADIPOQ	IGF1	ENSUMAP00000005319	ENSUMAP00000026349	Adiponectin isoform X2.	Insulin-like growth factor I isoform X1.	0.521
ADIPOQ	INS-IGF2	ENSUMAP00000005319	ENSUMAP00000008147	Adiponectin isoform X2.	Insulin, isoform 2-like; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.786
ADIPOQ	INSR	ENSUMAP00000005319	ENSUMAP00000019291	Adiponectin isoform X2.	Tyrosine-protein kinase receptor.	0.439
AKT1	AKT2	ENSUMAP00000034469	ENSUMAP00000026970	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.901
AKT1	AKT3	ENSUMAP00000034469	ENSUMAP00000016096	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.915
AKT1	APPL1	ENSUMAP00000034469	ENSUMAP00000026978	Non-specific serine/threonine protein kinase.	DCC-interacting protein 13-alpha.	0.835
AKT1	IGF1	ENSUMAP00000034469	ENSUMAP00000026349	Non-specific serine/threonine protein kinase.	Insulin-like growth factor I isoform X1.	0.411
AKT1	INS-IGF2	ENSUMAP00000034469	ENSUMAP00000008147	Non-specific serine/threonine protein kinase.	Insulin, isoform 2-like; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.477
AKT1	NFE2L2	ENSUMAP00000034469	ENSUMAP00000021462	Non-specific serine/threonine protein kinase.	Nuclear factor erythroid 2-related factor 2 isoform X2.	0.540
AKT1	PIK3R1	ENSUMAP00000034469	ENSUMAP00000010701	Non-specific serine/threonine protein kinase.	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1.	0.957
AKT2	AKT1	ENSUMAP00000026970	ENSUMAP00000034469	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.901
AKT2	AKT3	ENSUMAP00000026970	ENSUMAP00000016096	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.917
AKT2	APPL1	ENSUMAP00000026970	ENSUMAP00000026978	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	DCC-interacting protein 13-alpha.	0.835
AKT2	INS-IGF2	ENSUMAP00000026970	ENSUMAP00000008147	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin, isoform 2-like; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.505
AKT2	NFE2L2	ENSUMAP00000026970	ENSUMAP00000021462	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Nuclear factor erythroid 2-related factor 2 isoform X2.	0.540
AKT2	PIK3R1	ENSUMAP00000026970	ENSUMAP00000010701	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1.	0.957
AKT3	AKT1	ENSUMAP00000016096	ENSUMAP00000034469	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.915