(66 nodes) Primary neural tube formation network (Ursus maritimus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	MED12	LOW QUALITY PROTEIN: mediator of RNA polymerase II transcription subunit 12. (2045 aa)
	KDM6A	Lysine-specific demethylase 6A. (1347 aa)
	CTHRC1	LOW QUALITY PROTEIN: collagen triple helix repeat-containing protein 1. (113 aa)
	ABL1	Tyrosine-protein kinase. (1135 aa)
	PLXNB2	LOW QUALITY PROTEIN: plexin-B2. (1590 aa)
	SPINT2	Kunitz-type protease inhibitor 2 isoform X1. (232 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
	TSC1	Hamartin. (1168 aa)
	SFRP2	Secreted frizzled-related protein 2. (299 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	DVL2	LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2. (391 aa)
	TULP3	Tubby-like protein; Belongs to the TUB family. (462 aa)
	LRP2	Low-density lipoprotein receptor-related protein 2. (403 aa)
	ENSUMAP00000018664	annotation not available (401 aa)
	HIF1A	Hypoxia-inducible factor 1-alpha isoform X2. (823 aa)
	MTHFD1	C-1-tetrahydrofolate synthase, cytoplasmic. (935 aa)
	LUZP1	Leucine zipper protein 1 isoform X1. (1074 aa)
	GRHL3	Grainyhead-like protein 3 homolog isoform X1. (700 aa)
	ENSUMAP00000017266	annotation not available (147 aa)
	BRD2	Bromodomain-containing protein 2 isoform X2. (414 aa)
	SPINT1	Kunitz-type protease inhibitor 1. (501 aa)
	SEMA4C	semaphorin-4C; Belongs to the semaphorin family. (843 aa)
	CECR2	Cat eye syndrome critical region protein 2. (1454 aa)
	GLMN	Glomulin, FKBP associated protein. (600 aa)
	RALA	RAS like proto-oncogene A. (206 aa)
	ST14	Suppressor of tumorigenicity 14 protein. (807 aa)
	PHACTR4	Phosphatase and actin regulator. (706 aa)
	RARG	Retinoic acid receptor gamma isoform X1. (458 aa)
	PTCH1	Protein patched homolog 1. (1388 aa)
	COBL	Protein cordon-bleu. (1346 aa)
	PTK7	Inactive tyrosine-protein kinase 7; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1081 aa)
	NODAL	Nodal homolog. (271 aa)
	ENSUMAP00000010549	annotation not available (144 aa)
	BBS4	Bardet-Biedl syndrome 4 protein isoform X2. (325 aa)
	SHROOM3	Protein Shroom3. (1875 aa)
	HECTD1	LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase HECTD1. (2507 aa)
	FUZ	LOW QUALITY PROTEIN: protein fuzzy homolog. (373 aa)
	ENSUMAP00000007957	annotation not available (154 aa)
	DVL3	Segment polarity protein dishevelled homolog DVL-3. (423 aa)
	SCRIB	LOW QUALITY PROTEIN: protein scribble homolog. (844 aa)
	SEC24B	Protein transport protein Sec24B. (1144 aa)
	LIAS	Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (373 aa)
	CLUAP1	Clusterin-associated protein 1 isoform X3. (438 aa)
	LMO4	LIM domain transcription factor LMO4. (165 aa)
	TEAD2	Transcriptional enhancer factor TEF-4. (440 aa)
	CC2D2A	Coiled-coil and C2 domain-containing protein 2A isoform X1. (1619 aa)
	LOC103682075	Segment polarity protein dishevelled homolog DVL-1-like. (893 aa)
	BCL10	BCL10 immune signaling adaptor. (234 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
	MTHFD1L	Monofunctional C1-tetrahydrofolate synthase, mitochondrial. (759 aa)
	LHX2	LIM/homeobox protein Lhx2. (331 aa)
	OPA1	Dynamin-like 120 kDa protein, mitochondrial; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (997 aa)
	SETD2	Histone-lysine N-methyltransferase SETD2. (2520 aa)
	LRRC1	Leucine-rich repeat-containing protein 1. (493 aa)
	IFT57	Intraflagellar transport protein 57 homolog. (390 aa)
	KDM2B	LOW QUALITY PROTEIN: lysine-specific demethylase 2B. (685 aa)
	SFRP1	Secreted frizzled-related protein 1. (305 aa)
	SALL4	Sal-like protein 4. (1021 aa)
	PRICKLE1	Prickle-like protein 1. (804 aa)
	ARHGAP35	Rho GTPase-activating protein 35. (1500 aa)
	VASP	Vasodilator-stimulated phosphoprotein. (363 aa)
	SUFU	Suppressor of fused homolog. (489 aa)
	KAT2A	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (787 aa)
	MKS1	MKS transition zone complex subunit 1. (559 aa)
	MTHFR	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (695 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	VASP	ENSUMAP00000025680	ENSUMAP00000032747	Tyrosine-protein kinase.	Vasodilator-stimulated phosphoprotein.	0.419
ARHGAP35	PLXNB2	ENSUMAP00000032965	ENSUMAP00000025361	Rho GTPase-activating protein 35.	LOW QUALITY PROTEIN: plexin-B2.	0.481
BBS4	CLUAP1	ENSUMAP00000010546	ENSUMAP00000001079	Bardet-Biedl syndrome 4 protein isoform X2.	Clusterin-associated protein 1 isoform X3.	0.577
BBS4	ENSUMAP00000010549	ENSUMAP00000010546	ENSUMAP00000010549	Bardet-Biedl syndrome 4 protein isoform X2.	annotation not available	0.935
BBS4	IFT57	ENSUMAP00000010546	ENSUMAP00000006736	Bardet-Biedl syndrome 4 protein isoform X2.	Intraflagellar transport protein 57 homolog.	0.794
BCL10	TRAF6	ENSUMAP00000002851	ENSUMAP00000023966	BCL10 immune signaling adaptor.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.883
BMP4	PTCH1	ENSUMAP00000021648	ENSUMAP00000013120	Bone morphogenetic protein 4.	Protein patched homolog 1.	0.525
BRD2	ENSUMAP00000017266	ENSUMAP00000017238	ENSUMAP00000017266	Bromodomain-containing protein 2 isoform X2.	annotation not available	0.900
CC2D2A	MKS1	ENSUMAP00000002177	ENSUMAP00000031790	Coiled-coil and C2 domain-containing protein 2A isoform X1.	MKS transition zone complex subunit 1.	0.981
CECR2	SETD2	ENSUMAP00000015690	ENSUMAP00000005132	Cat eye syndrome critical region protein 2.	Histone-lysine N-methyltransferase SETD2.	0.412
CLUAP1	BBS4	ENSUMAP00000001079	ENSUMAP00000010546	Clusterin-associated protein 1 isoform X3.	Bardet-Biedl syndrome 4 protein isoform X2.	0.577
CLUAP1	ENSUMAP00000010549	ENSUMAP00000001079	ENSUMAP00000010549	Clusterin-associated protein 1 isoform X3.	annotation not available	0.500
CLUAP1	IFT57	ENSUMAP00000001079	ENSUMAP00000006736	Clusterin-associated protein 1 isoform X3.	Intraflagellar transport protein 57 homolog.	0.996
CLUAP1	KDM6A	ENSUMAP00000001079	ENSUMAP00000028759	Clusterin-associated protein 1 isoform X3.	Lysine-specific demethylase 6A.	0.430
DVL2	DVL3	ENSUMAP00000020655	ENSUMAP00000007934	LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2.	Segment polarity protein dishevelled homolog DVL-3.	0.511
DVL2	ENSUMAP00000007957	ENSUMAP00000020655	ENSUMAP00000007957	LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2.	annotation not available	0.492
DVL2	ENSUMAP00000018664	ENSUMAP00000020655	ENSUMAP00000018664	LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2.	annotation not available	0.400
DVL2	FZD3	ENSUMAP00000020655	ENSUMAP00000031112	LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2.	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.765
DVL2	LOC103682075	ENSUMAP00000020655	ENSUMAP00000002296	LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2.	Segment polarity protein dishevelled homolog DVL-1-like.	0.731
DVL2	LRP2	ENSUMAP00000020655	ENSUMAP00000018712	LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2.	Low-density lipoprotein receptor-related protein 2.	0.400