STRINGSTRING
NR0B2 NR0B2 SLC22A1 SLC22A1 SLC22A2 SLC22A2 SLC22A3 SLC22A3 PARK2-2 PARK2-2 ENSUMAP00000015922 ENSUMAP00000015922 CCDC180 CCDC180 PARK2 PARK2 LOC103678492 LOC103678492 AQP11 AQP11 STX12 STX12 STARD3NL STARD3NL SLCO2B1 SLCO2B1 SLC6A4 SLC6A4 STARD5 STARD5 SOAT2 SOAT2 ABCD3 ABCD3 SLC10A1 SLC10A1 ABCB11 ABCB11 LDLRAP1 LDLRAP1 ABCG8 ABCG8 SERAC1 SERAC1 ABCG5 ABCG5 SLC51B SLC51B TSPO2 TSPO2 SLCO1C1 SLCO1C1 SLC51A SLC51A SLC18A2 SLC18A2 ABCA12 ABCA12 SLC26A6 SLC26A6 ABCG4 ABCG4 GRAMD1C GRAMD1C STRA6 STRA6 MTTP MTTP NPC1L1 NPC1L1 SLC18A1 SLC18A1 STAR STAR NPC2 NPC2 LIMA1 LIMA1 SPG11 SPG11 P2RX1 P2RX1 TPCN2 TPCN2 OSBPL5-2 OSBPL5-2 OSBPL5 OSBPL5 KCNQ1 KCNQ1 AQP3 AQP3 HNF1A HNF1A AQP7 AQP7 ARV1 ARV1 CFTR CFTR VPS4B VPS4B AQP1 AQP1 LRP6 LRP6 SLC10A4 SLC10A4 RELCH RELCH RBP4 RBP4 SLCO1A2 SLCO1A2 LOC103677808 LOC103677808 SLC6A2 SLC6A2 OSBPL10 OSBPL10 OSBPL3 OSBPL3 SLC5A8 SLC5A8 SCARB1 SCARB1 ABCG1 ABCG1 SLC10A6 SLC10A6 PLTP PLTP OSBPL11 OSBPL11 WNK4 WNK4 VIP VIP SLC2A13 SLC2A13 PARK7 PARK7 LIPC LIPC AQP9 AQP9 APOC1 APOC1 ABCA2 ABCA2 KANSL1L KANSL1L APOB APOB OSBPL9 OSBPL9 SLC10A2 SLC10A2 GRAMD1B GRAMD1B SCP2 SCP2 LOC103660548 LOC103660548 SLC6A3 SLC6A3 OSBPL1A-2 OSBPL1A-2 OSBPL1A OSBPL1A LDLR LDLR OSBPL8 OSBPL8 NPC1 NPC1 MECP2 MECP2 SOAT1 SOAT1 MSR1 MSR1 ENSUMAP00000027960 ENSUMAP00000027960 SLC16A7 SLC16A7 SLC5A3 SLC5A3 AQP10 AQP10 SLC5A12 SLC5A12 LCAT LCAT SLC10A3 SLC10A3 VPS4A VPS4A PINK1 PINK1 RALBP1 RALBP1 OSBP OSBP GRAMD1A GRAMD1A SLC16A3 SLC16A3 STARD3 STARD3 CHRM5 CHRM5 ASIC3 ASIC3 OSBPL6 OSBPL6 OSBPL7 OSBPL7 ENSUMAP00000022403 ENSUMAP00000022403 STARD4 STARD4 OSBP2 OSBP2 SYK SYK SELENOM SELENOM CEL CEL SLC10A7 SLC10A7 SLC16A8 SLC16A8 APOM APOM ABCA1 ABCA1 PIP4K2A PIP4K2A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NR0B2Nuclear receptor subfamily 0 group B member 2. (279 aa)
SLC22A1LOW QUALITY PROTEIN: solute carrier family 22 member 1. (549 aa)
SLC22A2LOW QUALITY PROTEIN: solute carrier family 22 member 2. (514 aa)
SLC22A3Solute carrier family 22 member 3 isoform X2. (404 aa)
PARK2-2E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (176 aa)
ENSUMAP00000015922annotation not available (110 aa)
CCDC180LOW QUALITY PROTEIN: coiled-coil domain-containing protein 180. (1597 aa)
PARK2E3 ubiquitin-protein ligase parkin isoform X5. (153 aa)
LOC103678492Stimulated by retinoic acid gene 6 protein-like. (622 aa)
AQP11Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (272 aa)
STX12Syntaxin-12; Belongs to the syntaxin family. (259 aa)
STARD3NLMLN64 N-terminal domain homolog. (235 aa)
SLCO2B1Solute carrier organic anion transporter family member. (692 aa)
SLC6A4Sodium-dependent serotonin transporter. (677 aa)
STARD5LOW QUALITY PROTEIN: stAR-related lipid transfer protein 5. (244 aa)
SOAT2O-acyltransferase. (503 aa)
ABCD3ATP-binding cassette sub-family D member 3. (661 aa)
SLC10A1Solute carrier family 10 member 1. (370 aa)
ABCB11Bile salt export pump-like. (1319 aa)
LDLRAP1Low density lipoprotein receptor adapter protein 1. (296 aa)
ABCG8ATP-binding cassette sub-family G member 8. (672 aa)
SERAC1Serine active site containing 1. (649 aa)
ABCG5ATP-binding cassette sub-family G member 5. (626 aa)
SLC51BOrganic solute transporter subunit beta. (133 aa)
TSPO2Translocator protein 2. (173 aa)
SLCO1C1Solute carrier organic anion transporter family member. (705 aa)
SLC51AOrganic solute transporter subunit alpha. (341 aa)
SLC18A2Synaptic vesicular amine transporter. (497 aa)
ABCA12ATP-binding cassette sub-family A member 12. (2594 aa)
SLC26A6LOW QUALITY PROTEIN: solute carrier family 26 member 6. (784 aa)
ABCG4ATP-binding cassette sub-family G member 4. (648 aa)
GRAMD1CGRAM domain-containing protein 1C. (660 aa)
STRA6LOW QUALITY PROTEIN: stimulated by retinoic acid gene 6 protein homolog. (630 aa)
MTTPMicrosomal triglyceride transfer protein large subunit. (913 aa)
NPC1L1LOW QUALITY PROTEIN: Niemann-Pick C1-like protein 1. (1200 aa)
SLC18A1Chromaffin granule amine transporter isoform X1. (524 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
NPC2NPC intracellular cholesterol transporter 2. (149 aa)
LIMA1LIM domain and actin-binding protein 1. (761 aa)
SPG11Spatacsin isoform X2. (2445 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
TPCN2Two pore segment channel 2. (603 aa)
OSBPL5-2Oxysterol-binding protein-related protein 5. (164 aa)
OSBPL5LOW QUALITY PROTEIN: oxysterol-binding protein-related protein 5. (725 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1; Belongs to the potassium channel family. (410 aa)
AQP3Aquaporin 3 (Gill blood group); Belongs to the MIP/aquaporin (TC 1.A.8) family. (286 aa)
HNF1AHepatocyte nuclear factor 1-alpha. (660 aa)
AQP7Aquaporin-7 isoform X1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (354 aa)
ARV1ARV1 homolog, fatty acid homeostasis modulator. (281 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1475 aa)
VPS4BVacuolar protein sorting-associated protein 4B; Belongs to the AAA ATPase family. (444 aa)
AQP1Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
LRP6Low-density lipoprotein receptor-related protein 6 isoform X1. (1462 aa)
SLC10A4LOW QUALITY PROTEIN: sodium/bile acid cotransporter 4. (219 aa)
RELCHlisH domain and HEAT repeat-containing protein KIAA1468 homolog. (1223 aa)
RBP4Retinol-binding protein; Retinol-binding protein that mediates retinol transport in blood plasma. (189 aa)
SLCO1A2Solute carrier organic anion transporter family member. (666 aa)
LOC103677808Solute carrier organic anion transporter family member. (688 aa)
SLC6A2Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (629 aa)
OSBPL10Oxysterol-binding protein; Belongs to the OSBP family. (732 aa)
OSBPL3Oxysterol-binding protein; Belongs to the OSBP family. (886 aa)
SLC5A8Sodium-coupled monocarboxylate transporter 1; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (552 aa)
SCARB1LOW QUALITY PROTEIN: scavenger receptor class B member 1; Belongs to the CD36 family. (500 aa)
ABCG1LOW QUALITY PROTEIN: ATP-binding cassette sub-family G member 1. (661 aa)
SLC10A6Solute carrier family 10 member 6. (377 aa)
PLTPPhospholipid transfer protein. (496 aa)
OSBPL11Oxysterol-binding protein; Belongs to the OSBP family. (690 aa)
WNK4Serine/threonine-protein kinase WNK4. (1215 aa)
VIPVasoactive intestinal peptide. (170 aa)
SLC2A13Proton myo-inositol cotransporter; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (499 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
LIPCHepatic triacylglycerol lipase. (498 aa)
AQP9Aquaporin-9; Belongs to the MIP/aquaporin (TC 1.A.8) family. (295 aa)
APOC1Truncated apolipoprotein C-I; Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the in [...] (88 aa)
ABCA2ATP-binding cassette sub-family A member 2. (288 aa)
KANSL1LKAT8 regulatory NSL complex subunit 1-like protein isoform X1. (988 aa)
APOBApolipoprotein B-100. (4419 aa)
OSBPL9Oxysterol-binding protein; Belongs to the OSBP family. (754 aa)
SLC10A2Ileal sodium/bile acid cotransporter. (346 aa)
GRAMD1BGRAM domain-containing protein 1B isoform X1. (833 aa)
SCP2Non-specific lipid-transfer protein; Belongs to the thiolase-like superfamily. Thiolase family. (527 aa)
LOC103660548Oxysterol-binding protein; Belongs to the OSBP family. (882 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (617 aa)
OSBPL1A-2Oxysterol-binding protein-related protein 1/2. (212 aa)
OSBPL1AOxysterol-binding protein; Belongs to the OSBP family. (538 aa)
LDLRLow-density lipoprotein receptor. (927 aa)
OSBPL8Oxysterol-binding protein; Belongs to the OSBP family. (873 aa)
NPC1Niemann-Pick C1 protein. (1278 aa)
MECP2methyl-CpG-binding protein 2. (172 aa)
SOAT1O-acyltransferase. (557 aa)
MSR1Macrophage scavenger receptor types I and II isoform X1. (504 aa)
ENSUMAP00000027960annotation not available (155 aa)
SLC16A7Monocarboxylate transporter 2. (418 aa)
SLC5A3Sodium/myo-inositol cotransporter; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (718 aa)
AQP10Aquaporin-10; Belongs to the MIP/aquaporin (TC 1.A.8) family. (301 aa)
SLC5A12Sodium-coupled monocarboxylate transporter 2; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (619 aa)
LCATPhosphatidylcholine-sterol acyltransferase isoform X2. (441 aa)
SLC10A3P3 protein. (439 aa)
VPS4AVacuolar protein sorting-associated protein 4A; Belongs to the AAA ATPase family. (482 aa)
PINK1Serine/threonine-protein kinase PINK1, mitochondrial. (533 aa)
RALBP1LOW QUALITY PROTEIN: ralA-binding protein 1. (631 aa)
OSBPOxysterol-binding protein; Belongs to the OSBP family. (753 aa)
GRAMD1AGRAM domain-containing protein 1A. (804 aa)
SLC16A3Monocarboxylate transporter 4. (430 aa)
STARD3StAR related lipid transfer domain containing 3. (510 aa)
CHRM5Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (534 aa)
ASIC3LOW QUALITY PROTEIN: acid-sensing ion channel 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (513 aa)
OSBPL6Oxysterol-binding protein; Belongs to the OSBP family. (928 aa)
OSBPL7Oxysterol-binding protein; Belongs to the OSBP family. (857 aa)
ENSUMAP00000022403annotation not available (52 aa)
STARD4stAR-related lipid transfer protein 4. (116 aa)
OSBP2Oxysterol-binding protein; Belongs to the OSBP family. (649 aa)
SYKTyrosine-protein kinase SYK; Belongs to the protein kinase superfamily. Tyr protein kinase family. (610 aa)
SELENOMLOW QUALITY PROTEIN: selenoprotein M. (143 aa)
CELCarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (572 aa)
SLC10A7Sodium/bile acid cotransporter; Does not show transport activity towards bile acids or steroid sulfates; Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. (340 aa)
SLC16A8Solute carrier family 16 member 8. (512 aa)
APOMApolipoprotein M isoform X1. (188 aa)
ABCA1ATP-binding cassette sub-family A member 1. (2262 aa)
PIP4K2APhosphatidylinositol 5-phosphate 4-kinase type-2 alpha. (398 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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