STRINGSTRING
DGKQ DGKQ TTBK1 TTBK1 MKNK2 MKNK2 TSSK6 TSSK6 ENSUMAP00000008134 ENSUMAP00000008134 MAST1 MAST1 MAPK7 MAPK7 RPS6KA5 RPS6KA5 DCLK3 DCLK3 PRKD1 PRKD1 CDK1 CDK1 VRK3 VRK3 SMG1 SMG1 ENSUMAP00000010006 ENSUMAP00000010006 CLSPN CLSPN PRKAA1 PRKAA1 RICTOR RICTOR MAST4 MAST4 ATM ATM MAPKAPK5 MAPKAPK5 PRKCB PRKCB TNKS TNKS PLK1 PLK1 PRKDC PRKDC MAST3 MAST3 STK32C STK32C STK38 STK38 STK32A STK32A MAPK13 MAPK13 PRKCZ PRKCZ MAP3K12 MAP3K12 GALK1 GALK1 H3F3B H3F3B RPS6KA3 RPS6KA3 TTBK2 TTBK2 PRKCG PRKCG PRKCI PRKCI RPS6KA2 RPS6KA2 AKT3 AKT3 NLK NLK LOC103665481 LOC103665481 GRK2 GRK2 PRKCQ PRKCQ RPS6KA1 RPS6KA1 TGFBR1 TGFBR1 CSNK1G1 CSNK1G1 RPS6KB2 RPS6KB2 ENSUMAP00000017592 ENSUMAP00000017592 PRKCE PRKCE ENSUMAP00000017608 ENSUMAP00000017608 HIPK1 HIPK1 ENSUMAP00000017922 ENSUMAP00000017922 CAMK1D CAMK1D STK39 STK39 ATR ATR PRKCH PRKCH MYO3B MYO3B SGK3 SGK3 TLK1 TLK1 PDGFB PDGFB LOC103676389 LOC103676389 DYRK4 DYRK4 LATS2 LATS2 HIPK2 HIPK2 H3F3A H3F3A CHEK2 CHEK2 TLK2 TLK2 CDK2 CDK2 SYK SYK CAMK4 CAMK4 CDK5 CDK5 TTK TTK CAB39 CAB39 AURKB AURKB ERN1 ERN1 CSNK1D CSNK1D MAPK12 MAPK12 PRPF4B PRPF4B RIPK1 RIPK1 PINK1 PINK1 CAMK1 CAMK1 HIPK3 HIPK3 VRK2 VRK2 PRKX PRKX MAP4K1 MAP4K1 DYRK1B DYRK1B MAP3K10 MAP3K10 AKT2 AKT2 HIPK4 HIPK4 ROCK1 ROCK1 PRKCD PRKCD TBK1 TBK1 MORC3 MORC3 DYRK2 DYRK2 GAS6 GAS6 PKN3 PKN3 PRKCA PRKCA CSNK2A2 CSNK2A2 CLK1 CLK1 CAMK1G CAMK1G MAPKAPK3 MAPKAPK3 PRKAA2 PRKAA2 ENSUMAP00000030545 ENSUMAP00000030545 CAMKV CAMKV PBK PBK RPS6KB1 RPS6KB1 UHMK1 UHMK1 CHUK CHUK TSSK4 TSSK4 PDPK1 PDPK1 STK32B STK32B MTOR MTOR MKNK1 MKNK1 PRKD2 PRKD2 RPS6KA6 RPS6KA6 DCLK1 DCLK1 LRRK2 LRRK2 MAST2 MAST2 SGK1 SGK1 MAPK9 MAPK9 SBK2 SBK2 AKT1 AKT1 MARK3 MARK3 GSK3B GSK3B ENSUMAP00000035191 ENSUMAP00000035191 MAPKAPK2 MAPKAPK2 DYRK3 DYRK3 NEK7 NEK7 STK4 STK4 IKBKB IKBKB DYRK1A DYRK1A ILK ILK SGK2 SGK2 CSNK2A1 CSNK2A1 CDC7 CDC7 PKN2 PKN2 MYO3A MYO3A VRK1 VRK1 PCK1 PCK1 GSK3A GSK3A AURKA AURKA ENSUMAP00000003218 ENSUMAP00000003218 LATS1 LATS1 RPS6KA4 RPS6KA4 ULK1 ULK1 NEK6 NEK6 PAK2 PAK2 MAPK1 MAPK1 STK38L STK38L IKBKE IKBKE AURKC AURKC PKN1 PKN1 TSSK1B TSSK1B NTRK2 NTRK2 ULK3 ULK3 MAP3K13 MAP3K13 CSNK1A1 CSNK1A1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DGKQDiacylglycerol kinase. (886 aa)
TTBK1Tau-tubulin kinase 1. (756 aa)
MKNK2MAP kinase-interacting serine/threonine-protein kinase 2; Belongs to the protein kinase superfamily. (397 aa)
TSSK6Testis-specific serine/threonine-protein kinase 6; Belongs to the protein kinase superfamily. (322 aa)
ENSUMAP00000008134annotation not available (95 aa)
MAST1Microtubule-associated serine/threonine-protein kinase 1. (1558 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (264 aa)
RPS6KA5Ribosomal protein S6 kinase. (853 aa)
DCLK3Serine/threonine-protein kinase DCLK3. (621 aa)
PRKD1Serine/threonine-protein kinase D1. (874 aa)
CDK1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
VRK3Inactive serine/threonine-protein kinase VRK3 isoform X1. (509 aa)
SMG1SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3654 aa)
ENSUMAP00000010006annotation not available (254 aa)
CLSPNLOW QUALITY PROTEIN: claspin. (645 aa)
PRKAA1Non-specific serine/threonine protein kinase. (500 aa)
RICTORRapamycin-insensitive companion of mTOR isoform X3. (1684 aa)
MAST4Microtubule-associated serine/threonine-protein kinase 4 isoform X1. (2413 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3061 aa)
MAPKAPK5MAP kinase-activated protein kinase 5 isoform X2. (471 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (636 aa)
TNKSPoly [ADP-ribose] polymerase. (1333 aa)
PLK1Serine/threonine-protein kinase PLK. (573 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4135 aa)
MAST3Microtubule-associated serine/threonine-protein kinase 3. (1223 aa)
STK32CSerine/threonine-protein kinase 32C; Belongs to the protein kinase superfamily. (444 aa)
STK38Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (465 aa)
STK32ASerine/threonine-protein kinase 32A; Belongs to the protein kinase superfamily. (406 aa)
MAPK13Mitogen-activated protein kinase. (373 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (557 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (867 aa)
GALK1LOW QUALITY PROTEIN: galactokinase. (248 aa)
H3F3BH3 histone, family 3B. (191 aa)
RPS6KA3Ribosomal protein S6 kinase. (718 aa)
TTBK2Tau-tubulin kinase 2. (1239 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (654 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (569 aa)
RPS6KA2Ribosomal protein S6 kinase. (733 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (519 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (515 aa)
LOC103665481Putative Bcl-2 homologous antagonist/killer 2. (349 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (636 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
RPS6KA1Ribosomal protein S6 kinase. (719 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
CSNK1G1Casein kinase I isoform gamma-1 isoform X1; Belongs to the protein kinase superfamily. (459 aa)
RPS6KB2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (563 aa)
ENSUMAP00000017592annotation not available (120 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (226 aa)
ENSUMAP00000017608annotation not available (111 aa)
HIPK1Homeodomain-interacting protein kinase 1. (1199 aa)
ENSUMAP00000017922annotation not available (78 aa)
CAMK1DCalcium/calmodulin-dependent protein kinase type 1D. (360 aa)
STK39STE20/SPS1-related proline-alanine-rich protein kinase. (502 aa)
ATRSerine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2637 aa)
PRKCHProtein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa)
MYO3Bmyosin-IIIb isoform X2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1278 aa)
SGK3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (490 aa)
TLK1Serine/threonine-protein kinase tousled-like 1. (718 aa)
PDGFBPlatelet-derived growth factor subunit B. (234 aa)
LOC103676389Casein kinase I isoform epsilon-like; Belongs to the protein kinase superfamily. (459 aa)
DYRK4Dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform X2. (519 aa)
LATS2Non-specific serine/threonine protein kinase. (1030 aa)
HIPK2Homeodomain-interacting protein kinase 2 isoform X3. (1162 aa)
H3F3AH3 histone, family 3A. (160 aa)
CHEK2Serine/threonine-protein kinase Chk2 isoform X2. (542 aa)
TLK2Serine/threonine-protein kinase tousled-like 2 isoform X1. (762 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
SYKTyrosine-protein kinase SYK; Belongs to the protein kinase superfamily. Tyr protein kinase family. (610 aa)
CAMK4Calcium/calmodulin-dependent protein kinase type IV. (481 aa)
CDK5Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (361 aa)
TTKDual specificity protein kinase TTK isoform X2. (851 aa)
CAB39Calcium-binding protein 39. (341 aa)
AURKBAurora kinase B; Belongs to the protein kinase superfamily. (348 aa)
ERN1Serine/threonine-protein kinase/endoribonuclease IRE1. (1029 aa)
CSNK1DCasein kinase I isoform delta isoform X1. (430 aa)
MAPK12Mitogen-activated protein kinase. (260 aa)
PRPF4BSerine/threonine-protein kinase PRP4 homolog isoform X1. (1041 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (665 aa)
PINK1Serine/threonine-protein kinase PINK1, mitochondrial. (533 aa)
CAMK1Calcium/calmodulin-dependent protein kinase type 1 isoform X2; Belongs to the protein kinase superfamily. (409 aa)
HIPK3Homeodomain-interacting protein kinase 3 isoform X1. (1216 aa)
VRK2Serine/threonine-protein kinase VRK2 isoform X1. (494 aa)
PRKXcAMP-dependent protein kinase catalytic subunit PRKX. (329 aa)
MAP4K1Non-specific serine/threonine protein kinase; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (835 aa)
DYRK1BDual specificity tyrosine-phosphorylation-regulated kinase 1B. (596 aa)
MAP3K10LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 10. (270 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (520 aa)
HIPK4LOW QUALITY PROTEIN: homeodomain-interacting protein kinase 4. (576 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1355 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (725 aa)
TBK1Serine/threonine-protein kinase TBK1. (729 aa)
MORC3MORC family CW-type zinc finger protein 3. (927 aa)
DYRK2Dual specificity tyrosine-phosphorylation-regulated kinase 2. (538 aa)
GAS6LOW QUALITY PROTEIN: growth arrest-specific protein 6. (614 aa)
PKN3Serine/threonine-protein kinase N3. (723 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa)
CSNK2A2Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (345 aa)
CLK1Dual specificity protein kinase CLK1 isoform X1; Belongs to the protein kinase superfamily. (484 aa)
CAMK1GCalcium/calmodulin-dependent protein kinase type 1G; Belongs to the protein kinase superfamily. (384 aa)
MAPKAPK3MAP kinase-activated protein kinase 3 isoform X1; Belongs to the protein kinase superfamily. (384 aa)
PRKAA2Non-specific serine/threonine protein kinase. (390 aa)
ENSUMAP00000030545annotation not available (105 aa)
CAMKVLOW QUALITY PROTEIN: caM kinase-like vesicle-associated protein. (471 aa)
PBKLymphokine-activated killer T-cell-originated protein kinase. (324 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
UHMK1LOW QUALITY PROTEIN: serine/threonine-protein kinase Kist. (433 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (680 aa)
TSSK4Testis-specific serine/threonine-protein kinase 4. (338 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (572 aa)
STK32BSerine/threonine-protein kinase 32B; Belongs to the protein kinase superfamily. (391 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2531 aa)
MKNK1MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2; Belongs to the protein kinase superfamily. (415 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (833 aa)
RPS6KA6Non-specific serine/threonine protein kinase. (154 aa)
DCLK1LOW QUALITY PROTEIN: serine/threonine-protein kinase DCLK1. (722 aa)
LRRK2LOW QUALITY PROTEIN: leucine-rich repeat serine/threonine-protein kinase 2. (2513 aa)
MAST2Microtubule-associated serine/threonine-protein kinase 2 isoform X1. (1820 aa)
SGK1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (431 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
SBK2Serine/threonine-protein kinase SBK2; Belongs to the protein kinase superfamily. (350 aa)
AKT1Non-specific serine/threonine protein kinase. (514 aa)
MARK3Non-specific serine/threonine protein kinase. (746 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
ENSUMAP00000035191annotation not available (283 aa)
MAPKAPK2MAP kinase-activated protein kinase 2. (349 aa)
DYRK3Dual specificity tyrosine-phosphorylation-regulated kinase 3. (551 aa)
NEK7Serine/threonine-protein kinase Nek7 isoform X1; Belongs to the protein kinase superfamily. (302 aa)
STK4Serine/threonine-protein kinase 4. (496 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
DYRK1ADual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X2. (754 aa)
ILKIntegrin-linked protein kinase. (452 aa)
SGK2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (367 aa)
CSNK2A1LOW QUALITY PROTEIN: casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (391 aa)
CDC7LOW QUALITY PROTEIN: cell division cycle 7-related protein kinase. (569 aa)
PKN2Serine/threonine-protein kinase N2. (944 aa)
MYO3Amyosin-IIIa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1596 aa)
VRK1Serine/threonine-protein kinase VRK1 isoform X1; Belongs to the protein kinase superfamily. (416 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP]. (622 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (417 aa)
AURKAAurora kinase A; Belongs to the protein kinase superfamily. (405 aa)
ENSUMAP00000003218annotation not available (125 aa)
LATS1Serine/threonine-protein kinase LATS1 isoform X1. (975 aa)
RPS6KA4Non-specific serine/threonine protein kinase. (558 aa)
ULK1Serine/threonine-protein kinase ULK1. (835 aa)
NEK6Serine/threonine-protein kinase Nek6. (306 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
MAPK1Mitogen-activated protein kinase. (363 aa)
STK38LNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (431 aa)
IKBKELOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit epsilon. (692 aa)
AURKCAurora kinase C; Belongs to the protein kinase superfamily. (334 aa)
PKN1Serine/threonine-protein kinase N1. (913 aa)
TSSK1BTestis-specific serine/threonine-protein kinase 1; Belongs to the protein kinase superfamily. (368 aa)
NTRK2BDNF/NT-3 growth factors receptor. (466 aa)
ULK3Serine/threonine-protein kinase ULK3 isoform X6. (463 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (944 aa)
CSNK1A1Casein kinase I isoform alpha isoform X1; Belongs to the protein kinase superfamily. (380 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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